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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Sex chromosome associated satellite DNA: Evolution and conservation 显示文摘 | Singh L Purdom I F Jones K W | 1980 | Chromosome1980，79，： | 2 |
| 3 | Synthesis and DNA binding of spiroeyelic model compounds related to the neocarzinostatin chromophore 显示文摘 | Xi Z Jones G B Qabaja G Wright J Johnson F Goldberg I H | 1999 | Org Lett1999，1，9： | 1 |
| 4 | At what age can school-children provide effective chest compressions? An observational study from the Heartstart UK schools training programme显示文摘 | Jones I Whitfield R Colquhoun M | 2007 | British Medical Journal2007，334，7605： | 1 |
| 5 | Effect of fatigue on force sensation显示文摘 | JONES L A HUNTER I W | 1983 | EXP Neurol1983，81，： | 1 |
| 6 | Evaluation of Sediment Contamination by Polycyclic Aromatic Hydrocarbons in the Gironde Estuary显示文摘 | Budzinski H Jones I Belocq J P | 1997 | Mar Chem1997，58，12： | 1 |
| 7 | Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality显示文摘 | Kilgannon J H Jones A E Shapiro N I | 2010 | JAMA2010，303，： | 1 |
| 8 | The Microstructure of Sigma 1140 + SiC Fibres显示文摘 | Cheng T T Doorbar P Jones I P | 1999 | Mater Sci Tech1999，260，： | 1 |
| 9 | 显示文摘 | MARTIN P D JONES G R STRINGER F WILSON I D | 2003 | Analyst2003，128，： | 1 |
| 10 | Insulin-like growth factor and their binding proteins:Biological action显示文摘 | JONES J I CLEMMONS D R | 1995 | Endocr Rev1995，16，： | 1 |
| 11 | Acceleration perturbations of daily living: a comparison to 'whiplash'显示文摘 | Allen ME Weir Jones I Motiuk DR | 1994 | Spine1994，19，11： | 1 |
| 12 | Initial development into a novel technique for manufacturing a long fiber thermoplastic bioabsorbable composite: In-situ polymerization of poly-ε-caprolaetone 显示文摘 | Corden T J Jones I A Rudd C D | 1999 | Composites Part A1999，30，6： | 1 |
| 13 | Seventh report of the Joint National Committee on Prevention, Detection, Ev aluation,and Treatment of High Blood Pressure and evidence from new hypertension trials显示文摘 | Jones I)W Hall JE | 2004 | Hypertension2004，43，1： | 1 |
| 14 | Virtual reality simulation of surgery with haptic feedback based on the boundary element method显示文摘 | Wang P Becker A A Jones I A | | 0，，7： | 1 |
| 15 | Methodology of using delay-time analysis for a manufacturing industry显示文摘 | Jones B Jenkinson I Wang J | 2009 | Reliability En- gineering and System Safety2009，94，1： | 1 |
| 16 | Why do some countries produce so much more output per worker than others?显示文摘 | HALL R E JONES C I | 1999 | Quarterly Journal of Economics1999，114，1： | 1 |
| 17 | Avanafil for the treatment of erectile dysfunction:a multicenter,randomized,double-blind study in men with diabetes mellitus显示文摘 | GOLDSTEIN I JONES LA BELKOFF LH | 2012 | Mayo Clin Proc2012，87，9： | 1 |
| 18 | Clinical questions and uncertainty-pmlactin measurement in patients with schizophrenia and bipolar disorder 显示文摘 | Walters J Jones I | 2008 | J Psychopharmacol2008，22，2： | 1 |
| 19 | The microstructure of sigma 1140+ SiC fibers 显示文摘 | CHENG T T JONES I P SHATWELL R A | 1999 | Mater Sci Eng1999，260，： | 1 |
| 20 | A microsatelllte sequence closely linked to the waxy gene of Oryza sativa显示文摘 | Bligh H F J Till R I Jones C A | 1995 | Euphytica1995，86，： | 1 |
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