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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Lifetime physical activity and breast cancer risk in a multiethnic population:the Francisco Bay area breast cancer study显示文摘 | John EM Horn-ross PL Koo J | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，111： | 2 |
| 3 | The long-term cost effectiveness of treatments for benign prostatic hyperplasia显示文摘 | RACHAEL LD ANDREA KB JOHN PL | 2006 | Pharmaco Economics2006，24，2： | 1 |
| 4 | Nephrin localizes to the slit pore of the glomerular epithelial cell显示文摘 | Holzman LB John PL Kovari IA | 1999 | Kidney Int1999，56，4： | 1 |
| 5 | Cortieosteroids in the prevention and treatment of acute respiratory distress syndrome ( ARDS ) in adults : meta - analysis 显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 6 | Phytoestrogen intake and endometrial cancer risk 显示文摘 | Horn-Ross PL John EM Canchola AJ | 2003 | JNCI2003，95，15： | 1 |
| 7 | Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults : meta-analysis 显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 8 | ?Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis显示文摘 | John PL Christos MP Adriana T | 2000 | American Journal of Cardiology2000，85，08： | 1 |
| 9 | Nephrin localizes to the slit pore of the glomerular epithelial cell显示文摘 | Holzman LB John PL Kovari IA | 1999 | Kidney Int1999，56，4： | 1 |
| 10 | Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults:meta-analysis显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 11 | Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis 显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 12 | Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular development显示文摘 | Freeburg PB Robert B St John PL | 2003 | J Am Soc Nephrol2003，14，4： | 1 |
| 13 | Corticosteroids in theprevention and treatment of acute respiratory distresssyndrome(ARDS) in adults:meta-analysis显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 14 | Laparoscopy with laparoscopic ultrasonography in the TNM staging of pancreatic carcinoma显示文摘 | John TG Wright A Allan PL | 1999 | World J Surg1999，23，9： | 1 |
| 15 | Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes显示文摘 | Bao L Spiller OB St John PL | 2002 | Kidney Int2002，62，6： | 1 |
| 16 | The long-term-cost effectiveness of treatments for benign prostatic hy-perplasia显示文摘 | Rachael LD Andera KB John PL | 2006 | Pharmaco Economics2006，24，2： | 1 |
| 17 | Phytoestrogen consumption and breast cancer risk in a multiethnic population:the Bay Area Breast Cancer Study显示文摘 | Horn-Ross PL John EM Lee M | 2001 | Am J Epidemiol2001，154，5： | 1 |
| 18 | Cortieosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: recta-analysis显示文摘 | Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 19 | Nephrin localizes to the slit pore of the glomerular epithelial cell 显示文摘 | Holzman LB John PL Kovari IA | 1999 | Kidney Int1999，56，4： | 1 |
| 20 | Assessing phytoestrogen exposure in epidemiologic studies development of a database ( U- nited States) 显示文摘 | Honl-Ross PL Lee M John EM | 2000 | Cancer Causes Control2000，11，4： | 1 |
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