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| 1 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 2 | Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration显示文摘INTRODUCTIONThe liver is one of the organs,which have potentialregenerative capability in mammalian animal.The study of the canine model indicated that theliver could regenerate to original size after 70%hepatectomy in only two weeks.So it is a hotresearch topic for the cellular and molecularmechanism of liver regeneration. | Cheng J Zhong YW Liu Y Dong J Yang JZ Chen JM | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 3 | A New Anthraquinone from Clinopodium polycephalum Glyceroyl-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracene Carboxylate显示文摘A new anthraquinone, Glyceroyl-l, 6, 8 -trihydroxy-3 -methyl-9, 10-dioxo-2 -anthracenecarboxylate 1, was isolated from Clinopodium polycephalum. The chemical structure was determined by spectroscopic methods. | Chen, JY Chen, JM Wan, CL Yang, JS Xiao, PG | 1998 | Chinese Chemical Letters1998，9，2： | 5 |
| 4 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 5 | Maximum standardized uptake value on PET/CT in preoperative assessment of lymph node metastasis from thoracic esophageal squamous cell carcinoma显示文摘The presence of lymph node metastasis is an important prognostic factor for patients with esophageal cancer.Accurate assessment of lymph nodes in thoracic esophageal carcinoma is essential for selecting appropriate treatment and forecasting disease progression.Positron emission tomography combined with computed tomography(PET/CT)is becoming an important tool in the workup of esophageal carcinoma.Here,we evaluated the effectiveness of the maximum standardized uptake value(SUVmax)in assessing lymph node metastasis in esophageal squamous cell carcinoma(ESCC)prior to surgery.Fifty-nine surgical patients with pathologically confirmed thoracic ESCC were retrospectively studied.These patients underwent radical esophagectomy with pathologic evaluation of lymph nodes.They all had18F-FDG PET/CT scans in their preoperative staging procedures.None had a prior history of cancer.The pathologic status and PET/CT SUVmax of lymph nodes were collected to calculate the receiver operating characteristic(ROC)curve and to determine the best cutoff value of the PET/CT SUVmax to distinguish benign from malignant lymph nodes.Lymph node data from 27 others were used for the validation.A total of 323 lymph nodes including 39 metastatic lymph nodes were evaluated in the training cohort,and 117lymph nodes including 32 metastatic lymph nodes were evaluated in the validation cohort.The cutoff point of the SUVmax for lymph nodes was 4.1,as calculated by ROC curve(sensitivity,80%;specificity,92%;accuracy,90%).When this cutoff value was applied to the validation cohort,a sensitivity,a specificity,and an accuracy of 81%,88%,and 86%,respectively,were obtained.These results suggest that the SUVmax of lymph nodes predicts malignancy.Indeed,when an SUVmax of 4.1 was used instead of 2.5,FDG-PET/CT was more accurate in assessing nodal metastasis. | Amos JM Ela Bella Ya-Rui Zhang Wei Fan Kong-Jia Luo Tie-Hua Rong Peng Lin Hong Yang Jian-Hua Fu | 2014 | Chinese Journal of Cancer2014，33，4： | 3 |
| 6 | Nutritional status of gastric cancer patients after total gastrectomy 显示文摘 | Bae JM Park JW Yang HK | 1998 | World J Surg1998，22，3： | 2 |
| 7 | Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells显示文摘 | Yang JM Vassil A Hait WN | 2002 | Biochem Pharmacol2002，63，5： | 1 |
| 8 | Prevalence of diabetes among men and women in China显示文摘 | Yang WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，12： | 1 |
| 9 | A novel threonine -> proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens 显示文摘 | Yang JM Lee S Bang HD | 1997 | J Invest Dermatol1997，109，1： | 1 |
| 10 | Prevalence of Diabetes among Men andWomen in China显示文摘 | Yang WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，： | 1 |
| 11 | Reversal of multidrug resistance to epirubicin by cyclosporine A in liposomes or intralipid显示文摘 | Lo YL Liu FI Yang JM | 2001 | Anticancer Res2001，21，1： | 1 |
| 12 | Over expression of extracellular ma- trix metalloproteinase inducer in muhidrug resistant cancer cells 显示文摘 | Yang JM Xu Z Wu H | 2003 | Mol Cancer Res2003，1，： | 1 |
| 13 | A dynamic subspace method for hyper spectral image classification显示文摘 | JM Yang BC Kuo PT Yu | 2010 | IEEE Transactions on geoscience and remote sensing2010，48，7： | 1 |
| 14 | Prevalence of diabetesamong men and women in China显示文摘 | Yang WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，： | 1 |
| 15 | New 5eco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and1,2-dehydro-neomajucin from Illicium jiadifengpi 显示文摘 | Yokoyama R Huang JM Yang CS | 2002 | J NatProd2002，65，： | 1 |
| 16 | Prevalence of diabetes among men and women in China显示文摘 | Yang WY Lu JM Weng JD | 2010 | New England Journal of Medicine2010，362，12： | 1 |
| 17 | prevalence of diabetes a- mong men and women in China显示文摘 | Yang WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，12： | 1 |
| 18 | Merrilactone A, a novel neurotrophic sesquiterpene dilactone from lllicium merrillianum 显示文摘 | Huang JM Yokoyama R Yang CS | 2000 | Tetrahedron Lett2000，41，32： | 1 |
| 19 | Preventive effects of bitter melon(Momordica charantia)against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNKpathways in high-fat-fed OLETF rats显示文摘 | YANG SJ CHOI JM PARK SE | 2015 | Journal of Nutritional Biochemistry2015，26，3： | 1 |
| 20 | Prevalence of diabetesamong men and women in China显示文摘 | Yang WY Lu JM Weng JP | 2010 | N Engl J Med2010，362，12： | 1 |
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