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1篇 您的检索式：作者名="JING Runan"

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		题名	作者	年代	出处	被引量
	1	Measurement of Free and Glucuronidated Cardamonin in Rat Plasma and Bile Using UPLC-MS/MS and Its Application to a Pharmacokinetic and Bile Excretion Study显示文摘A rapid and accurate ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry(UPLC-MS/MS)method was established and validated for the measurement of two forms of cardamonin,i.e.,free and glucuronidated,in the plasma and bile of rats.Cardamonin and an internal standard(1,8-dihydroxyanthraquinone)were extracted from plasma and bile with ethyl ether via liquid-liquid extraction.The analytes in the extracts were separated by an Agilent Zorbax Stable Bond-C18 column(2.1 mm×50 mm,1.8μm)under isocratic elution conditions[acetonitrile(A)and 0.1%ammonium formate in water(B),40:60(volume ratio)]with a flow rate of 0.4 mL/min,and mass spectrometry in negative ion MRM mode was implemented for analysis.Good linearity over the wide ranges of 0.01–5μg/mL for plasma and 0.025–10μg/mL for bile samples was acquired.Method validation was performed according to the FDA guidelines for bioanalytical methods.	WU Yi JING Runan JIA Guihua WANG Yixiao YU Tianmiao ZHANG Weidong	2019	Chemical Research in Chinese Universities2019，35，6：	0

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