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    题名 作者 年代 出处 被引量
1Management of diabetic dyslipidemia: An update显示文摘Diabetic dyslipidemia is a cluster of lipoprotein abnormalities characterized by increased triglyceride level, decreased high-density lipoprotein-cholesterol levels and increase in small dense low-density lipoprotein(LDL) particles. It is extremely common in type 2 diabetes(T2DM) affecting around 70 % of patients.Diabetic is a significant risk factor for atherosclerotic cardiovascular disease(ASCVD) which is the most common cause of death in the United States and LDL-cholesterol is the number 1 predictor of ASCVD events in T2DM. The purpose of this review is to discuss the pathophysiology and treatment of diabetic dyslipidemia. In this review, we have discussed both nonpharmacological and pharmacological treatment modalities including major treatment trials which have impacted the cardiovascular outcomes in patients with diabetes. Statin therapy is the mainstay of treatment to reduce ASCVD by decreasing LDL-C by 30%-49% or at least 50% depending on risk level. Attractive adjunctive therapies include Ezetimibe which is more cost effective and PCSK9 inhibitors which display potent LDL-cholesterol lowering and ASCVD event reduction. For severe hypertriglyceridemia, to avert the risk of pancreatitis, both fish oil and fenofibrate in concert with diet is the best strategy.Ishwarlal Jialal Gurdeep Singh 2019World Journal of Diabetes2019,10,5:4
2Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role显示文摘Senthil Kumar Venugopal Sridevi Devaraj Ishwarlal Jialal 2005Current Opinion in Nephrology and Hypertension2005,,1:3
3C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells: Implications for the Metabolic Syndrome and Atherothrombosis显示文摘Sridevi Devaraj Dan Yan Xu Ishwarlal Jialal 2003Circulation: Journal of the American Heart Association2003,,3:2
4C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype显示文摘Sridevi Devaraj Ishwarlal Jialal 2011Arteriosclerosis, Thrombosis, and Vascular Biology2011,,6:2
5Reactive protein increase plasm inogen activator inhibitorl expression and activity in human a orticendo the lialcells:implications for the metabolic syndrome and a therothrombosis显示文摘Devaraj S Xu DY Jialall C 2003Circulation2003,107,3:1
6Effects of increasing does of alpha-tocopherol in providing protection of low-density liporprotein from oxidation显示文摘Fuller CJ Huet BA Jialal I 1998Am J Cardiol1998,1581,:1
7Inflammation and atherosclerosis:The value of the high-sensitivity C-reactive protein assay as a risk marker显示文摘Jialal I Devaraj S 2001Am J Clin Pathol2001,,:1
8Inflammation and atherosclerosis:the value of the highsensitive creative protein assay as a risk marker显示文摘Jialal I Devaraj S 2001Am J Cli Pathol2001,,:1
9Direct demonstration of an antiinflammatory effect of Simvastatin in subjects with the Metabol- ic syndrome显示文摘DEVARAJ S CHAN E JIALAL I 2006Journal of Clinical Endocrinology & Metabolism2006,91,11:1
10Diabetes is a proinflammatory state : a translational perspective 显示文摘Devaraj S Dasu MR Jialal I 2010Expert Rev Endoerinol Metab2010,5,1:1
11Diabetes is a proinflammatory state:a translational perspective显示文摘Devaraj S Dasu MR Jialal I 2010Expert Rev Endocrinol Metab2010,5,1:1
12Oxidative stress,inflammation,and diabetic vasculopathies:the role of alpha tocopherol therapy显示文摘Jialal I Devaraj S Venugopal SK 2002Free Radic Res2002,36,12:1
13C-reactive protein increases plasminogen activator inhibitor-1 exptession and activity in human aortic endothelial cells:implications for the metabolic syndrome and atherothrombosis显示文摘Devaraj S Xu DY Jialal I 2003Cir culation2003,107,4:1
14C-reactive protein risk marker or mediator in A therothrombosis 显示文摘Jialal I Devaraj S Venugopal SK 2004Hypertension2004,44,:1
15C-reactive protein increases plasminogen activator inhibitor-lexpression and activity inhuman aortic endothelialcells:implications for the metabolic syndrome and atherothrombosis显示文摘Devaraj S Xu DY Jialal I 2003Circulation2003,107,3:1
16C-reactive protein decreases prostacyclin release from human aortic endothelial cells显示文摘Venugopal SK Devaraj S Jialal I 2003Circulation2003,108,14:1
17Inflammation and atherosclerosis:the value of the high-sensitivity C-reactive protein assay as a risk marker显示文摘Jialal I Devaraj S 2001Am J Clin Pathol2001,116,1:1
18C-reactive protein increases plasminogen activator inhibitor-1 expression and activity inhuman aortic endothelial cells:implications for the metabolic syndrome and atherothrombosis显示文摘Devaraj S Xu DY Jialal I 2003Circulation2003,107,:1
19Candesartan inhibits Toll-like receptor expression and activity hoth in vitro and in vivo 显示文摘Dasu MR Riosvelasco AC Jialal I 2009Atherosclerosis2009,202,1:1
20Toll- like receptor status in obesity and metabolic syndrome: A Translational Perspective 显示文摘Jialal I Kaur H Devaraj S 2014J Clin Endocrinol Metab2014,99,1:1
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