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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 3 | Dynamic cross-linking of polymeric binders based on host-guest interactions for silicon anodes in lithium ion batteries显示文摘 | KWON T W JEONG Y K DENIZ E | 2015 | ACS Nano2015，9，11： | 1 |
| 4 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
| 5 | The RING-H2-FINGER protein APCI 1 as a target of hydrogen peroxide 显示文摘 | CHANG T S JEONG W LEE D Y | 2004 | Free Radical Biol Med2004，37，4： | 1 |
| 6 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 7 | Reconfigured sigmoid colon neourethra: substitution of ref ractory posterior urethral st ricture显示文摘 | Lee Y T Chu T W Jeong H S | 2005 | Urology2005，65，： | 1 |
| 8 | Synthesis of olivine LiFePO4 cathode materials by mechanical alloying using iron(Ⅲ) raw material显示文摘 | Kim C W Lee M H Jeong W T | 2005 | J Power Sources2005，146，12： | 1 |
| 9 | Anisotropic Etching of InP and InGaAs by Using an Inductively Coupled Plasma in C12/N2 and Cl2/Ar Mixtures at Low Bias Power显示文摘 | BAE J W JEONG C H LIM J T | 2007 | Journal of the Korean Physical Society2007，50，4： | 1 |
| 10 | Electrochemical cycling behavior of LiCoO2 cathode prepared by mechanical alloying of hydroxides 显示文摘 | Jeong W T Lee K S | 2002 | Journal of Power Sources2002，104，： | 1 |
| 11 | Effect of dissolved gas on the viscosity of HIPS in the manufacture of microcellular plastics 显示文摘 | Chong T H Ha Y W Jeong D J | 2003 | Polym Eng Sci2003，43，6： | 1 |
| 12 | Adsorption kinetics and behaviors of cellulase components on microcrystalline cellulose显示文摘 | KIM D W KIM T S JEONG Y K | | 0，，06： | 1 |
| 13 | Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder can- cer显示文摘 | Yun S J Jeong P Kim W T | 2012 | Int J Oncol2012，41，： | 1 |
| 14 | Improvement in demand-controlled ventilation simulation on multi-purposed facilities under an occupant based ventilation standard 显示文摘 | JEONG J W CHOI A NO S T | 2010 | Simulation Modelling Practice and Theory2010，18，1： | 1 |
| 15 | An application of CFD to improve warm-up performance of 3-way auto-catalyst by high surface area and low thermalmass显示文摘 | Jeong S J Kim W S Kim T | 2002 | Int J of Vehicle Design2002，29，3： | 1 |
| 16 | Synthesis and electrochemical properties of olivine LiFePO4 as a cathode material prepared by mechanical alloying显示文摘 | Kwon S J Kim C W Jeong W T | 2004 | J Power Sources2004，137，1： | 1 |
| 17 | Grain-size strengthening in equal-channel-angular-pressing processed AZ31 Mg alloys with a constant texture 显示文摘 | KIM W J JEONG H T | 2005 | Materials Transactions2005，46，2： | 1 |
| 18 | Stable generation of GeV-class electron beams from self-guided laser-plasma channels显示文摘 | Hafz N A M Jeong T M Choi W | 2008 | Nature Photonics2008，2，： | 1 |
| 19 | Synthesis and structural characteristics of LiCoO2 powders prepared by mechanical alloying of LiOH and Co(OH)2显示文摘 | Jeong W T Lee K S | 2001 | J Alloys and Compounds2001，322，： | 1 |
| 20 | A streaming service based on partition and mapping of media block显示文摘 | LEE C D JEONG T W AHN J Y | 2012 | International Journal of Innovative Computing Information and Control2012，8，2： | 1 |
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