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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | 择期手术患者术前禁食现状的探讨显示文摘 | Jeannette T 吴燕 | 2003 | 上海护理2003，3，3： | 9 |
| 3 | Phylogenetic relationships of the north American sturgeons(Order Acipenseriformes) based on mitochondrial DNA sequences显示文摘 | Jeannette K Paul A F Cavender T M | 2000 | Molecular Phylogenetics and Evolution2000，16，1： | 1 |
| 4 | Changes in distribution, cell associations and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin - c during acute to chronic maturation of spinal cord scar tissue 显示文摘 | Xiufeng T Jeannette ED Stephen JAD | 2003 | J Neurosci Res2003，71，： | 1 |
| 5 | Abscissic acid specific expression of RAB1 involves activation of anion channels in Arabidopsis thaliana suspension cells 显示文摘 | Ghelis T Dellis O Jeannette E | 2000 | FEBS Letters2000，474，1： | 1 |
| 6 | Consensus-degen- erate hybrid oligonucleotide primers (CODEHOPs)for the detec- tion of novel viruses in non-human primates显示文摘 | Jeannette P S Jonathan T R Gregory B | 2009 | Methods2009，49，1： | 1 |
| 7 | Preoperative fasting: old habits die hard 显示文摘 | Jeannette T C Elizabeth H W | 2002 | The American Journal of Nursing2002，102，5： | 1 |
| 8 | Preoperative Fasting : Old Habits Die Hard: Research and published guidelines no longer support the routine use of ' NPO after midnight,' but the practice persists 显示文摘 | Jeannette T Crenshaw Elizabeth H Winslow | 2002 | American Journal of Nursing2002，102，5： | 1 |
| 9 | Ad- vanced waterborne polyisocyanates for polyurethane coat- ings显示文摘 | SCHMOB J M JEANNETTE T WUSTMANN U | 1999 | European Coatings Journal1999，7，8： | 1 |
| 10 | Preoperative Fasting:Old Habits Die Hard显示文摘 | Jeannette T Crenshaw Elizabeth H Winslow | 2002 | American Journal of Nursing2002，102，5： | 1 |
| 11 | Advanced Waterborne Polyisocyanates for Polyurethane Coatings显示文摘 | Schmob J M Jeannette T Wustmann U | 1999 | European Coatings Journal1999，37，7： | 1 |
| 12 | Preoperative fasting: Oldhabits die hard显示文摘 | JEANNETTE T C ELIZABETH H W | 2002 | Am J Nurs2002，102，5： | 1 |
| 13 | Crenshaw显示文摘 | JEANNETTE T | 2002 | AJN2002，102，5： | 1 |
| 14 | Advanced Waterborne Polyisocyanates for Polyurethane Coatings显示文摘 | Schmob J M Jeannette T Wustmann U | 1999 | European Coat- ings Journal1999，37，7： | 1 |
| 15 | Advanced waterborne polyisocyanates for polyurethane coatings 显示文摘 | Jeannette T Wustmann U | 1999 | ECJ1999，，78： | 1 |
| 16 | A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus 显示文摘 | Jeannette M Grit T | 1998 | J Clin Invest1998，102，4： | 1 |
| 17 | Preoperative Fasting: Old Habits Die Hard显示文摘 | Jeannette T Crenshaw Elizabeth H Winslow | 2002 | American Journal of Nursing2002，102，5： | 1 |
| 18 | Advanced Waterborne Polyisocyanates for Polyurethane Coatings显示文摘 | Jeannette T Wustmann U | 1999 | European Coatings Journal1999，，7： | 1 |
| 19 | Preoperative fasting: Old habits die hard显示文摘 | Jeannette T | 2002 | AM J Nuts2002，102，5： | 1 |
| 20 | Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience显示文摘 | Kosten T A David A K Jeannette Y | 2007 | Neurobiology of Learning and Memory2007，88，： | 1 |
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