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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Genes for epidermal growth factor receptor, transforming growth factor, epidermal growth factor and their expression in human gliomas in vivo显示文摘 | Ekstrancl AJ James CD Cavenee WK | 1991 | Cancer Res1991，51，8： | 2 |
| 3 | Cholangiocarcinoma:diagnosis and evaluation of resectability by CT and sonography as a procedure complementary to cholangiography显示文摘 | Johnson CD James EM | 1988 | Am J Roanergenol1988，151，5： | 1 |
| 4 | Incidence and risk fac- tors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，： | 1 |
| 5 | Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deleteion of sequences encoding portions of the N- and/or C-terminal tail 显示文摘 | Ekstrand AJ Sugawa N James CD | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 6 | Incidence and risk factors for stroke in pregnancy and the puerperium 显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，3： | 1 |
| 7 | Identifying the attributes of instructional quality in ambulatory teaching sites : A validation study of the MedEd IQ显示文摘 | James PA Kreiter CD Shipengrover J | 2002 | Faro Med2002，34，4： | 1 |
| 8 | Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas显示文摘 | Sugawa N Ekstrand AJ James CD | 1990 | Proc Natl Acad Sci USA1990，87，21： | 1 |
| 9 | ECop(EGFR-coamplified and overexpressed protein),a novel protein,regulates NF-kB transcriptional activity and associated apoptotic response in an IjBa-dependent manner显示文摘 | Park S James CD | 2005 | Oncogene2005，24，： | 1 |
| 10 | Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism 显示文摘 | Park S James CD | 2003 | Cancer Res2003，63，： | 1 |
| 11 | Incidence and risk factors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyne- col2005，106，： | 1 |
| 12 | Altered molecular pathways in gliomas : an overview of clinically relevent issues 显示文摘 | Rao RD James CD | 2004 | Semin Oncol2004，31，5： | 1 |
| 13 | microRNAs in Gliomas:SmallRegulators of a Big Problem显示文摘 | Silber J James CD Hodgson JG | 2009 | Neuromolecular Med2009，11，3： | 1 |
| 14 | mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma muhiforme cells显示文摘 | Panner A James CD Berger MS | 2005 | Mol Cell Biol2005，25，20： | 1 |
| 15 | Loss of heterozygosity in ma lignant gliomas involves at least three distinct regions on chromosome 10显示文摘 | James CD Boethius J | 1993 | H umGenet1993，92，： | 1 |
| 16 | MicroRNAs in gliomas: small regulators of a big problem显示文摘 | Silber J James CD Hodgson JG | 2009 | Neuromolecular Medicine2009，11，： | 1 |
| 17 | Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth and re- sponse to therapy using bioluminescence imagin显示文摘 | Ozama T James CD | 2010 | J Vis Exp2010，7，41： | 1 |
| 18 | Mechanisms ofchemoresistance to alkylating agents in malignant glioma显示文摘 | Sarkaria JN Kitange GJ James CD | 2008 | ClinCancer Res2008，14，10： | 1 |
| 19 | Clonal genomic alterations in gliomamalignancy stages显示文摘 | James CD Carlblom E Dumanski JP | 1988 | Cancer Res1988，48，19： | 1 |
| 20 | The cause of neurinal degeneration in Alzheimer's Disease显示文摘 | Tracey CD Dickson PA | 2000 | Progress in Neurobiology2000，60，： | 1 |
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