| 1 | Helicobacter pylori and gastric cancer: current status of the Austrian-Czech-German gastric cancer prevention trial (PRISMA-Study)显示文摘AIM To test the hypothesis that Helicobacter pylori eradication alone can reduce the incidence of gastric cancer in a subgroup of individuals with an increased risk for this fatal disease.METHODS It is a prospective, randomized,double-blind, placebo-controlled multinational multicenter trial. Men between 55 and 65 years of age with a gastric cancer phenotype of Helicobacterpylori gastritis are randomized to receive a 7-day course of omeprazole 2 × 20 mg,clarithromycin 2 × 500 mg, and amoxicillin 2 ×lg for 7 days, or omeprazole2 × 20mg plusplacebo. Follow - up endoscopy is scheduled 3months after therapy, and thereafter in one-year intervals. Predefined study endpoints are gastric cancer, precancerous lesions (dysplasia, adenoma), other cancers, anddeath.RESULTS Since March 1998, 1524 target patients have been screened, 279 patients (18.3%) had a corpus-dominant type of H.pylori gastritis, and 167 of those were randomized (58.8%). In the active treatment group (n -- 86), H. pylori infection infection was cured in 88.9% of patients. Currently, thecumulative follow-up time is 3046 months (253.8patient-years, median follow-up 16 months). So far, none of the patients developed gastric cancer or any precancerous lesion. Three(1.8%) patients reached study endpoints other than gastric cancer.CONCLUSION Among men between 55 and 65years of age, the gastric cancer phenotype of H.pylori gastritis appears to be more common than expected. Further follow- up and continuing recruitment are necessary to fulfil the main aim of the study. | S.Miehlke C.Kirsch B.Dragosics M.Gschwantler G.Oberhuber D.Antos P.Dite J.Lauter J.Labenz A.Leodolter P.Malfertheiner A.Neubauer G.Ehninger M.Stolte E.Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 5 |
| 3 | 幽门螺旋菌感染的临床与诊断显示文摘早在100年前人们就观察到胃粘膜上有细菌生长,直到1983年Marshall等首次成功地对该菌进行了培养,即现在称为的幽门螺旋菌,从此开创了对该菌致病机制和临床意义的深入研究。幽门螺旋菌感染在世界上是最常见的感染性疾病之一,西方国家感染率随年龄增加而增加(每年增加1%)<。人是该菌的宿主,病原菌主要通过人人传播,污染的食物或饮水在感染环节中的意义尚不清楚。流行病学感染模式与甲型肝炎相似,卫生条件差的国家在儿童有很高的感染率。众所周知,亦可通过医疗器械,如经内窥镜及pH探条传染。 | J.Labenz G.Brsch 李明 | 1995 | 德国医学1995，12，4： | 0 |
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