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| 1 | Signaling events during initiation of arbuscular mycorrhizal symbiosis显示文摘Under nutrient‐limiting conditions, plants will enter into symbiosis with arbuscular mycorrhizal(AM) fungi for the enhancement of mineral nutrient acquisition from the surrounding soil. AM fungi live in close, intracellular association with plant roots where they transfer phosphate and nitrogen to the plant in exchange for carbon. They are obligate fungi,relying on their host as their only carbon source. Much has been discovered in the last decade concerning the signaling events during initiation of the AM symbiosis, including the identification of signaling molecules generated by both partners. This signaling occurs through symbiosis‐specific gene products in the host plant, which are indispensable for normal AM development. At the same time, plants have adapted complex mechanisms for avoiding infection by pathogenic fungi, including an innate immune response to general microbial molecules, such as chitin present in fungal cell walls. How it is that AM fungal colonization is maintained without eliciting a defensive response from the host is still uncertain. In this review, we present a summary of the molecular signals and their elicited responses during initiation of the AM symbiosis, including plant immune responses and their suppression. | Alexa M.Schmitz Maria J.Harrison | 2014 | Journal of Integrative Plant Biology2014，56，3： | 7 |
| 2 | 隐匿性乙型肝炎病毒感染可通过密切接触传播显示文摘目的探索一名出生时乙肝疫苗免疫成功后仍感染乙肝病毒的小孩的感染来源。方法采集小孩及其父母的血标本进行HBV血清学标志物和病毒载量检测,使用酚氯仿法提取HBV DNA,PCR扩增HBV S基因,将扩增产物进行克隆并测序,利用Mega 5.0和Bioedit 7.0对测序结果进行分析。结果父亲和母亲均为隐匿性乙型肝炎病毒感染,父亲、母亲、儿子的PCR产物分别获得12、11和9个克隆株。父亲克隆株的血清型为adrq+,ayw1,ayw,ayr,基因型为C2、B、B/C;母亲克隆株的血清型为ayw1,adw2,adwq+,基因型为C5、B、B/C、C/G;儿子克隆株的血清型为adrq+,基因型仅为C2。S基因序列进化发生树显示,儿子的所有克隆序列与父亲大多数的克隆序列聚集在一起,而与母亲的克隆序列没有聚集。来自儿子和父亲的S基因克隆序列有相同的氨基酸突变模式(T118K、T123N、G145A)。结论儿子乙型肝炎病毒感染的来源是父亲,提示隐匿性乙型肝炎病毒感染可通过家庭密切接触传播。 | 胡莉萍 刘德平 陈钦艳 Tim J.Harrison 何翔 王学燕 李海 谭超 杨庆利 方钟燎 | 2016 | 应用预防医学2016，22，2： | 4 |
| 3 | Defining strawberry shape uniformity using 3D imaging and genetic mapping显示文摘Strawberry shape uniformity is a complex trait,influenced by multiple genetic and environmental components.To complicate matters further,the phenotypic assessment of strawberry uniformity is confounded by the difficulty of quantifying geometric parameters‘by eye’and variation between assessors.An in-depth genetic analysis of strawberry uniformity has not been undertaken to date,due to the lack of accurate and objective data.Nonetheless,uniformity remains one of the most important fruit quality selection criteria for the development of a new variety.In this study,a 3D-imaging approach was developed to characterise berry shape uniformity.We show that circularity of the maximum circumference had the closest predictive relationship with the manual uniformity score.Combining five or six automated metrics provided the best predictive model,indicating that human assessment of uniformity is highly complex.Furthermore,visual assessment of strawberry fruit quality in a multi-parental QTL mapping population has allowed the identification of genetic components controlling uniformity.A“regular shape”QTL was identified and found to be associated with three uniformity metrics.The QTL was present across a wide array of germplasm,indicating a potential candidate for marker-assisted breeding,while the potential to implement genomic selection is explored.A greater understanding of berry uniformity has been achieved through the study of the relative impact of automated metrics on human perceived uniformity.Furthermore,the comprehensive definition of strawberry shape uniformity using 3D imaging tools has allowed precision phenotyping,which has improved the accuracy of trait quantification and unlocked the ability to accurately select for uniform berries. | Bo Li Helen M.Cockerton Abigail WJohnson Amanda Karlström Eleftheria Stavridou Greg Deakin Richard J.Harrison | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Amplicon-based metagenomics identified candidate organisms in soils that caused yield decline in strawberry显示文摘A phenomenon of yield decline due to weak plant growth in strawberry was recently observed in non-chemo-fumigated soils,which was not associated with the soil fungal pathogen Verticillium dahliae,the main target of fumigation.Amplicon-based metagenomics was used to profile soil microbiota in order to identify microbial organisms that may have caused the yield decline.A total of 36 soil samples were obtained in 2013 and 2014 from four sites for metagenomic studies;two of the four sites had a yield-decline problem,the other two did not.More than 2000 fungal or bacterial operational taxonomy units(OTUs)were found in these samples.Relative abundance of individual OTUs was statistically compared for differences between samples from sites with or without yield decline.A total of 721 individual comparisons were statistically significant–involving 366 unique bacterial and 44 unique fungal OTUs.Based on further selection criteria,we focused on 34 bacterial and 17 fungal OTUs and found that yield decline resulted probably from one or more of the following four factors:(1)low abundance of Bacillus and Pseudomonas populations,which are well known for their ability of supressing pathogen development and/or promoting plant growth;(2)lack of the nematophagous fungus(Paecilomyces species);(3)a high level of two non-specific fungal root rot pathogens;and(4)wet soil conditions.This study demonstrated the usefulness of an amplicon-based metagenomics approach to profile soil microbiota and to detect differential abundance in microbes. | Xiangming Xu Thomas Passey Feng Wei Robert Saville Richard J.Harrison | 2015 | Horticulture Research2015，2，1： | 1 |
| 5 | Stretch Reflexes in the Rectus Abdominis Muscle in Man显示文摘 | S. E.Myriknas I. D.Beith P. J.Harrison | 2004 | Experimental Physiology2004，，4： | 1 |
| 6 | Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low‐ and high‐phosphate environments显示文摘 | HeungsopShin Hwa‐SooShin Gary R.Dewbre Maria J.Harrison | 2004 | The Plant Journal2004，，4： | 1 |
| 7 | Arbuscular mycorrhizal symbiosis is accompanied by local and systemic alterations in gene expression and an increase in disease resistance in the shoots显示文摘 | JinyuanLiu IgnacioMaldonado‐Mendoza MelinaLopez‐Meyer FooCheung Christopher D.Town Maria J.Harrison | 2007 | The Plant Journal2007，，3： | 1 |
| 8 | Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China显示文摘 | YouchunWang XiouhuaLi AijingSong ChuntaoZhang YingChen ChangrongChen YishengLin LipingShun LuilanLi YanchunLiu JianYang BoweiYang QioupingTang Tim J.Harrison | 2005 | J Med Virol2005，，4： | 1 |
| 9 | Profiling elite male 100-m sprint performance:The role of maximum velocity and relative acceleration显示文摘Purpose:This study aimed to determine the accuracy of a 4 split time modelling method to generate velocity-time and velocity-distance variables in elite male 100-m sprinters and subsequently to assess the roles of key sprint parameters with respect to 100-m sprint performance.Additionally,this study aimed to assess the differences between faster and slower sprinters in key sprint variables that have not been assessed in previous work.Methods:Velocity-time and velocity-distance curves were generated using a mono-exponential function from 4 split times for 82 male sprinters during major athletics competitions.Key race variables-maximum velocity,the acceleration time constant(τ),and percentage of velocity lost(vLoss)-were derived for each athlete.Athletes were divided into tertiles,based on 100-m time,with the first and third tertiles considered to be the faster and slower groups,respectively,to facilitate further analysis.Results:Modelled split times and velocities displayed excellent accuracy and close agreement with raw measures(range of mean bias was-0.2%to 0.2%,and range of intraclass correlation coefficients(ICCs)was 0.935 to 0.999)except for 10-m time(mean bias was 1.6%±1.3%,and the ICC was 0.600).The 100-m sprint performance time and all 20-m split times had a significant near-perfect negative correlation with maximum velocity(r≥-0.90)except for the 0 to 20-m split time,where a significantly large negative correlation was found(r=-0.57).The faster group had a significantly higher maximum velocity andτ(p<0.001),and no significant difference was found for vLoss(p=0.085).Conclusion:Coaches and researchers are encouraged to utilize the 4 split time method proposed in the current study to assess several key race variables that describe a sprinter’s performance capacities,which can be subsequently used to further inform training. | Robin Healy Ian C.Kenny Andrew J.Harrison | 2022 | Journal of Sport and Health Science2022，11，1： | 1 |
| 10 | Regeneration and utilization of nutrients during collapse of a Mesodinium rubrum red tide and its influence on phytoplankton species composition显示文摘High-biomass red tides occur frequently in some semi-enclosed bays of Hong Kong where ambient nutrients are not high enough to support such a high phytoplankton biomass. These high-biomass red tides release massive inorganic nutrients into local waters during their collapse. We hypothesized that the massive inorganic nutrients released from the collapse of red tides would fuel growth of other phytoplankton species. This could influence phytoplankton species composition. We tested the hypothesis using a red tide event caused by Mesodinium rubrum(M. rubrum) in a semi-enclosed bay, Port Shelter. The red tide patch had a cell density as high as 5.0×10~5 cells L^(-1), and high chlorophyll a(63.71 μg L^(-1)). Ambient inorganic nutrients(nitrate:NO_3^-, ammonium: NH_4^+, phosphate: PO_4^(3-), silicate: SiO_4^(3-)) were low both in the red tide patch and the non-red-tide patch(clear waters outside the red tide patch). Nutrient addition experiments were conducted by adding all the inorganic nutrients to water samples from the two patches followed by incubation for 9 days. The results showed that the addition of inorganic nutrients did not sustain high M. rubrum cell density, which collapsed after day 1, and did not drive M. rubrum in the non-red-tide patch sample to the same high-cell density in the red tide patch sample. This confirmed that nutrients were not the driving factor for the formation of this red tide event, or for its collapse. The death of M. rubrum after day 1 released high concentrations of NO_3^-,PO_4^(3-), SiO_4^(3-), NH_4^+, and urea. Bacterial abundance and heterotrophic activity increased, reaching the highest on day 3 or 4, and decreased as cell density of M. rubrum declined. The released nutrients stimulated growth of diatoms, such as Chaetoceros affinis var. circinalis, Thalassiothrix frauenfeldii, and Nitzschia sp., particularly with additions of SiO_4^(3-) treatments, and other species. These results demonstrated that initiation of M. rubrum red tides in the bay was not directly driven by nutrients.However, the massive inorganic nutrients released from the collapse of the red tide could induce a second bloom in low-ambient nutrient water, influencing phytoplankton species composition. | Yafeng ZHANG Xiuxian SONG Paul J.HARRISON Sheng LIU Zhiming YU Jinjun KAN Peiyuan QIAN Hao LIU Kedong YIN | 2018 | Science China Earth Sciences2018，61，10： | 1 |
| 11 | 血清骨桥蛋白和肝癌的关系可能归因于乙型肝炎病毒慢性感染显示文摘目的研究乙型肝炎病毒(HBV)感染是否增加血清骨桥蛋白(OPN)浓度及OPN与肝癌之间的关系。方法按病例对照研究原理,研究对象分为6个组:HBsAg无症状携带者组(ASC组)、HBsAg阳性慢性肝病组、HBsAg阳性肝癌组、HBsAg阴性其他肿瘤组、HBsAg阴性肝癌和慢性肝脏病组、健康对照组。用化学发光微粒子免疫检测法检测血清HBsAg浓度,用酶联免疫吸附试验(ELISA)检测血清OPN浓度,用Mann-Whitney U检验和线性回归分析法进行统计分析。结果6组研究对象共241名。HBsAg阳性肝癌组与HBsAg阴性其他肿瘤组、健康对照组血清OPN浓度差异均有统计学意义(P值均=0.0001)。在HBsAg阳性肝癌组与ASC组、HBsAg阳性慢性肝病组间,以及在HBsAg阴性肝癌和慢性肝脏病组与健康对照组间,血清OPN浓度差异均无统计学意义(P值分别为0.360、0.588和0.075)。多元线性回归分析结果显示,血清HBsAg浓度是与OPN浓度有关的唯一变量(P=0.0001)。结论血清OPN浓度可能与肝癌本身无关,而与HBV慢性感染有关,在HBV感染者中,可以用血清HBsAg浓度预测血清OPN浓度。 | 刘华兵 王学燕 陈钦艳 张陆娟 胡莉萍 Tim J.Harrison 方钟燎 | 2020 | 应用预防医学2020，26，2： | 1 |
| 12 | Systematic review and meta‐analysis of sentinel node biopsy in thyroid cancer显示文摘 | S. P.Balasubramanian B. J.Harrison | 2011 | Br J Surg2011，，3： | 1 |
| 13 | Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low‐ and high‐phosphate environments显示文摘 | HeungsopShin Hwa‐SooShin Gary R.Dewbre Maria J.Harrison | 2004 | The Plant Journal2004，，4： | 1 |
| 14 | Gene expression in HCV‐associated hepatocellular carcinoma – upregulation of a gene encoding a protein related to the ubiquitin‐conjugating enzyme显示文摘 | Ghada M.El‐Nady RogerLing Tim J.Harrison | 2003 | Liver International2003，，5： | 1 |
| 15 | Quantitative trait loci controlling Phytophthora cactorum resistance in the cultivated octoploid strawberry(Fragaria×ananassa)显示文摘The cultivated strawberry,Fragaria×ananassa(Fragaria spp.)is the most economically important global soft fruit.Phytophthora cactorum,a water-borne oomycete causes economic losses in strawberry production globally.A biparental cross of octoploid cultivated strawberry segregating for resistance to P.cactorum,the causative agent of crown rot disease,was screened using artificial inoculation.Multiple putative resistance quantitative trait loci(QTL)were identified and mapped.Three major effect QTL(FaRPc6C,FaRPc6D and FaRPc7D)explained 37%of the variation observed.There were no epistatic interactions detected between the three major QTLs.Testing a subset of the mapping population progeny against a range of P.cactorum isolates revealed no significant interaction(p=0.0593).However,some lines showed higher susceptibility than predicted,indicating that additional undetected factors may affect the expression of some quantitative resistance loci.Using historic crown rot disease score data from strawberry accessions,a preliminary genome-wide association study(GWAS)of 114 individuals revealed an additional locus associated with resistance to P.cactorum.Mining of the Fragaria vesca Hawaii 4 v1.1 genome revealed candidate resistance genes in the QTL regions. | Charlotte F.Nellist Robert J.Vickerstaff Maria K.Sobczyk César Marina-Montes Fiona M.Wilson David W.Simpson Adam B.Whitehouse Richard J.Harrison | 2019 | Horticulture Research2019，6，1： | 1 |
| 16 | Analysis and model dependencies in medium‐range ensembles: Two transplant case‐studies显示文摘 | M. S. J.Harrison T. N.Palmer D. S.Richardson R.Buizza | 2007 | QJR Meteorol Soc2007，，559： | 1 |
| 17 | 长壁法采煤粉尘的控制显示文摘1960年以来,美国煤矿用长壁法采煤的持续增加。已有108种开采方法。长壁开采法的优点是,生产效率比较高,能提高安全性,煤的回收率较高。但是,呼吸性粉尘危害严重影响了长壁法采煤的全面推广。从1980年起,美国矿业局开始研究控制长壁采煤工作面作业人员接触呼吸性粉尘的有效方法。研究表明,几种控制方法联合使用能更好地控制尘源。这些方法包括减少粉尘的产生,稀释粉尘,捕尘或降尘,以及个体防护。一、控制粉尘的方法 1.截煤机清洁器某些设计不合理的安装在截煤机上的喷雾装置,其喷咀喷出的雾正对着进风侧滚筒的截割和装载区域,把粉尘带离工作面和滚筒,与清洁的进风混合(图1a)。 | Robert A.Jankowsk i Fred N.K issell J.Harrison Dan ie l 刘后金 | 1990 | 工业安全与防尘1990，，9： | 0 |
| 18 | Does the McNeill Alexander model accurately predict maximum walking speed in novice and experienced race walkers?显示文摘Background:Mathematical models propose leg length as a limiting factor in determining the maximum walking velocity.This study evaluated the effectiveness of a leg length-based model in predicting maximum walking velocity in an applied race walking situation,by comparing experienced and novice race walkers during conditions where strictly no flight time(FT)was permitted and in simulated competition conditions(i.e.,FT<40 ms).Methods:Thirty-four participants(18 experienced and l6 novice race walkers)were recruited for this investigation.An Optojump Next system(8 m)was used to determine walking velocity,step frequency,step length,ground contact time,and FT during race walking over a range of velocities.Comparisons were made between novice and experienced participants in predicted maximum velocity and actual velocities achieved with no flight and velocities with FT<40 ms.The technical effectiveness of the participants was assessed using the ratio of maximum velocity to predicted velocity.Results:In novices,no significant difference was found between predicted and maximum walking speeds without FT but there was a small 5.8%gain in maximum speed when FT≤40 ms.In experienced race walkers,there was a significant reduction in maximum walking speed compared with predicted maximum(p<0.01)and a 11.7%gain in maximum walking speed with FT<40 ms.Conclusion:Leg length was a good predictor of maximal walking velocity in novice walkers but not a good predictor of maximum walking speed in well-trained walkers who appear to have optimised their walking technique to make use of non-visible flight periods of less than 40 ms.The gain in velocity above predicted maximum may be a useful index of race walking proficiency. | Andrew J.Harrison Patrick G.Molloy Laura-Anne M.Furlong | 2018 | Journal of Sport and Health Science2018，7，3： | 0 |
| 19 | 2010年1月至2015年3月美国因缺氧和吸入烃类气体/蒸气引起的石油天然气开采工人急性死亡调查显示文摘2013年,1名来自旧金山加州大学的职业医师向美国疾病预防控制中心(CDC)国家职业安全与卫生研究院(National Institute for Occupational Safety and Health,NIOSH)和职业安全与健康管理局(Occupational Safety and Health Administration,OSHA)报告美国西部2名石油天然气开采工人的死亡病例,引起死亡的原因可能是由于工人打开油气储罐的舱门时,暴露在烃类气体/蒸气(hydrocarbon gases and vapors,HGVs)中且合并缺氧。 | Robert J.Harrison Kyla Retzer Michael J.Kosnett Michael Hodgson Todd Jordan Sophia Ridl Max Kiefer 杨凤 | 2017 | 上海预防医学2017，29，12： | 0 |
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