| 2 | 孕16~21周的人绒毛膜促性腺激素水平及其对先兆子痫的预测显示文摘To determine whether levels of beta human choriogonadotropin (β - hCG) during the second trimester are a predictor of pre-eclampsia. Methods. A prospective study of 784 women was conducted between their 16th and 20th week of pregnancy. Primigravidas and multigravidas were analyzed separately, and the cutoff point was determined using a receiver operating characteristic curve. The accuracy of β - hCG levels in the prediction of preecla-mpsiawas evaluated. The likelihood ratios were calculated for different levels of β - hCG in both groups. Results. Pre-eclampsia prevalence was 7.1% among primigravidas and 4.6% among multigravidas. The cutoff concentration was 2.0 MoM in both groups. For primigravidas and multigravidas, respectively, the area below the curve was 0.96 and 0.95; sensitivity was 88.5% and 100% ; specificity was 92.0% and 85.6% ; positive predictive value was 0.46 and 0.25; and negative predictive value was 0.99 and 1.0. With a cutoff concentration of 2.0 MoM of β - hCG, the positive likelihood ratio was 11.1 in primigravidas and 6.9 in multigravidas. Conclusion. This study shows that measuring levels of β - hCG during the second trimester of pregnancy is useful in clinical practice to identify pregnant women who will develop pre-eclampsia. | Roiz-Herná ndez J Cabello-Martnez J.D.J Ferná n-dez-Meja M 柳蕴 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，5： | 0 |
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