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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 3 | Rock mechanics ap - plied to the study of mckbursts 显示文摘 | Cook N G W Hook E Pretorious J P G | 1966 | J S Afr Inst Min Metall1966，66，10： | 1 |
| 4 | DEA models for supply chain efficiency evaluation显示文摘 | Liang L Feng Y Cook W D Zhu J | 2006 | Annals of Operations Research2006，145，1： | 1 |
| 5 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds 显示文摘 | Hirt G W Amsden A A Cook J L | 1974 | J Comp Phys1974，14，3： | 1 |
| 6 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 7 | Construction and testing of micmsatellite database containing more than 500 tomoto varieties 显示文摘 | BREDEMEIJER G M M COOK R J GANAL M W | 2002 | Theor Appl Genet2002，105，： | 1 |
| 8 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 9 | Simultaneous axial and rotational electron beam velocity measurement using a phosphor scintillator显示文摘 | He W Cooke S J Cross A W | 2001 | Review of Scientific Instruments2001，72，5： | 1 |
| 10 | Elevated troponin and myocardial infarction in the intensive care unit: a prospective study显示文摘 | Lim W Qushmaq I Cook D J | 2005 | Crit Care2005，9，6： | 1 |
| 11 | Phytoastrogens and cardiovascular health显示文摘 | Lissin L W Cooke J P | 2000 | J Am Coll Cardiol2000，35，6： | 1 |
| 12 | The deuterium to hydrogen ratios of sap in trees: implications for water sources and tree ring deuterium to hydrogen ratios显示文摘 | White J W C Cook E R Lawrence J R | 1985 | Geochimica Et Cosmochimiea Aeta1985，49，： | 1 |
| 13 | Assessment of the uniformity of wheat and tomato varieties at DNA microsatel- lite loci 显示文摘 | Cooke R J Bredemeijer G M M Ganal M W el al | 2003 | 132 : 33 ! -3412003，132，： | 1 |
| 14 | Rock mechanics applied to the study of rockbursts显示文摘 | Cook N G W,Hoek E,Pretorius J P G, | 1966 | Journal of the South African Institute of Mining and1966，66，10： | 1 |
| 15 | Alternative secondary goals in DEA cross efficiency evaluation 显示文摘 | Liang L Wu J Cook W D | 2008 | International Journal of Production Economics2008，113，10： | 1 |
| 16 | The prolactin gene is located on chromosome 6 in humans显示文摘 | OWERBACH D RUTTER W J COOKE N E | 1981 | Science1981，212，4496： | 1 |
| 17 | The long term proghostic significance of oestrogen receptor analysis in early carcinoma of the breast显示文摘 | Winstanley J Cooke T George W D | 1991 | Br J Cancer1991，64，1： | 1 |
| 18 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 19 | Multiple variable proportionality in date envelopment analysis 显示文摘 | Cook W D Zhu J | 2011 | Operations Research2011，59，1： | 1 |
| 20 | A synthetic oestrus- exciting compound显示文摘 | Cook J W Dodds E C Hewtt C L | 1933 | Nature1933，131，： | 1 |
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