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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Adipose derived stem cells and nerve regeneration显示文摘Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts. | Alessandro Faroni Richard JP Smith Adam J Reid | 2014 | Neural Regeneration Research2014，9，14： | 7 |
| 4 | Adelaide地区大气重力波的气辉观测显示文摘利用澳大利亚Adelaide(34.5°S,138.5°E)地区7年(1995—2001年)的OH和OI气辉观测数据,以及同地区中频雷达所测背景风场数据,通过最大熵谱分析方法,统计分析了该地区大尺度重力波的传播特性.结果表明,(1)在中层顶气辉观测区,利用OH气辉探测到48个重力波事件,利用OI气辉探测到29个重力波事件,这些重力波的周期和水平相速度分别集中在68min和36m/s左右,具有东南向的优势传播方向,平均仰角为8°~10°,接近水平方向传播;(2)通过OH气辉和OI气辉观测到了同一个重力波事件,并根据两个高度上观测到的扰动相位差判断该重力波为上行波. | 江葵 丁锋 万卫星 Reid I M Woithe J M | 2007 | 空间科学学报2007，27，6： | 3 |
| 5 | Review of inverse analysis for indirect measurement of impact force显示文摘 | Inoue H Harrigan J J Reid S R | 2001 | Applied Mechanics Review2001，54，6： | 2 |
| 6 | The crushing strength of aluminium alloy form at high rates of strain显示文摘 | Reid S R Tan P J Harrigan J J | 2001 | Impact Engineering and Application2001，2，： | 2 |
| 7 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 8 | Predictors of progression in Barrett’s esophagus III: baseline flow cytometric variables显示文摘 | Peter S Rabinovitch Gary Longton Patricia L Blount Douglas S Levine Brian J Reid | 2001 | The American Journal of Gastroenterology2001，，11： | 2 |
| 9 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 10 | Machine vision-based guidance system for an agricultural small-grain harvester显示文摘 | BensonE R Reid J F Zhang Q | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 11 | Bioavailability of persistent organic pollutants in soils and sedimentsa perspective on mechanisms, consequences and assessment 显示文摘 | REID B J JONES K C SEMPLE K T | 2000 | Environmental Pollution2000，108，1： | 1 |
| 12 | Articulated body motion capture by stochastic search 显示文摘 | Deutscher J Reid I | 2005 | International Journal of Computer Vision2005，61，2： | 1 |
| 13 | Potential uses of probiotics in clinical practice显示文摘 | REID G J SEBULSKY M T | 2003 | Clin Microbiol Rev2003，16，4： | 1 |
| 14 | The role of the cytoskeleton in cellular adhesion molecule expression in tumor necrosis factor - stimulated endothelial cells 显示文摘 | VANDEN BERG E REID M D EDWARDS J D | 2004 | Cell Biochem2004，91，5： | 1 |
| 15 | Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial 显示文摘 | DUFFIELD A J LILLICO M E REID B W | 2002 | Cancer Epidemi Biomarkers Prey2002，11，： | 1 |
| 16 | Incision and diferen-tial bedrock uplift along the Indus River near Nanga Parbal,Pakistan Himalaya,from 10Be and 26Al exposure age dating of bedrock straths 显示文摘 | Leland J Reid M R Burbank D W | 1998 | Earth and Planetary Science Letters1998，154，14： | 1 |
| 17 | An opti mized grapevine RNA isolation procedure and statisti- cal determination of reference genes for real-time RT- PCR during berry development 显示文摘 | Reid K E Olsson N Sehlosser J | 2006 | BMC plant biology2006，6，1： | 1 |
| 18 | Effects of flexion-extension movements of the head and spine upon the spinal cord and nerve roots显示文摘 | Reid J | 1960 | J Neurol Neurosurg Psychiatry1960，23，3： | 1 |
| 19 | Evaluation of ethylene inhibitors for postharvest treatment of Gypsophila paniculata L显示文摘 | Newman J P Dodge L L Reid M S | | 0，，01： | 1 |
| 20 | Potential uses of probiotics in clinieal practice显示文摘 | Reid G Jass J Sebulskey MT | 2003 | Clin Mierobiol Revi2003，16，6： | 1 |
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