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| 1 | Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet显示文摘We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol | N. NISHIZAWA S. SHIMANUKI H. FUJIHASHI H. WATANABE Y. FUDAMOTO AND T. NAGASAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, Sagae, Yamagata 991 Ka | 1996 | Biomedical and Environmental Sciences1996，9，2： | 24 |
| 2 | Serrated polyps of the colon and rectum:Remove or not?显示文摘In recent years,the serrated neoplasia pathway where serrated polyps arise as a colorectal cancer has gained considerable attention as a new carcinogenic pathway.Colorectal serrated polyps are histopathologically classified into hyperplastic polyps(HPs),sessile serrated lesions,and traditional serrated adenomas;in the serrated neoplasia pathway,the latter two are considered to be premalignant.In western countries,all colorectal polyps,including serrated polyps,apart from diminutive rectosigmoid HPs are removed.However,in Asian countries,the treatment strategy for colorectal serrated polyps has remained unestablished.Therefore,in this review,we described the clinicopathological features of colorectal serrated polyps and proposed to remove HPs and sessile serrated lesions≥6 mm in size,and traditional serrated adenomas of any size. | Wataru Sano Daizen Hirata Akira Teramoto Mineo Iwatate Santa Hattori Mikio Fujita Yasushi Sano | 2020 | World Journal of Gastroenterology2020，26，19： | 12 |
| 3 | Study on dynamic response of embedded long span corrugated steel culverts using scaled model shaking table tests and numerical analyses显示文摘A series of scaled-model shaking table tests and its simulation analyses using dynamic finite element method were performed to clarify the dynamic behaviors and the seismic stability of embedded corrugated steel culverts due to strong earth-quakes like the 1995 Hyogoken-nanbu earthquake. The dynamic strains of the embedded culvert models and the seismic soil pressure acting on the models due to sinusoidal and random strong motions were investigated. This study verified that the cor-rugated culvert model was subjected to dynamic horizontal forces (lateral seismic soil pressure) from the surrounding ground, which caused the large bending strains on the structure; and that the structures do not exceed the allowable plastic deformation and do not collapse completely during strong earthquake like Hyogoken-nanbu earthquake. The results obtained are useful for design and construction of embedded long span corrugated steel culverts in seismic regions. | 车爱兰 IWATATE Takahiro 葛修润 | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，3： | 10 |
| 4 | Feasibility of single-incision laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To assess the safety of single-incision laparoscopic cholecystectomy(SILC) for acute cholecystitis.METHODS: All patients who underwent SILC at Sano Hospital(Kobe, Japan) between January 2010 and December 2014 were included in this retrospective study. Clinical data related to patient characteristics and surgical outcomes were collected from medical records. The parameters for assessing the safety of the procedure included operative time, volume of blood loss, achievement of the critical view of safety, use of additional trocars, conversion to laparotomy, intraoperative and postoperative complications, and duration of postoperative hospital stay. Patient backgrounds were statistically compared between those with and without conversion to laparotomy.RESULTS: A total of 100 patients underwent SILC for acute cholecystitis during the period. Preoperative endoscopic treatment was performed for suspected choledocholithiasis in 41 patients(41%). The mean time from onset of acute cholecystitis was 7.7 d. According to the Updated Tokyo Guidelines(TG13) for the severity of cholecystitis, 86 and 14 patients had grade Ⅰ and grade Ⅱ acute cholecystitis, respectively. The mean operative time was 87.4 min. The mean estimated blood loss was 80.6 mL. The critical view of safety was obtained in 89 patients(89%). Conversion laparotomy was performed in 12 patients(12%). Postoperative complications of Clavien-Dindo grade Ⅲ or greater were observed in 4 patients(4%). The mean duration of postoperative hospital stay was 5.7 d. Patients converted from SILC to laparotomy tended to have higher days after onset.CONCLUSION: SILC is feasible for acute cholecystitis; in addition, early surgical intervention may reduce the risk of laparotomy conversion. | Taro Ikumoto Hidetsugu Yamagishi Mineo Iwatate Yasushi Sano Masahito Kotaka Yasuo Imai | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 8 |
| 5 | Effective use of the Japan Narrow Band Imaging Expert Team classification based on diagnostic performance and confidence level显示文摘Five years have passed since the Japan Narrow Band Imaging Expert Team (JNET) classification was proposed in 2014. However, the diagnostic performance of this classification has not yet been established. We conducted a retrospective study and a systematic search of Medical Literature Analysis and Retrieval System On-Line. There were three retrospective single center studies about the diagnostic performance of this classification. In order to clarify this issue, we reviewed our study and three previous studies. This review revealed the diagnostic performance in regards to three important differentiations.(1) Neoplasia from non-neoplasia;(2) malignant neoplasia from benign neoplasia;and (3) deep submucosal invasive cancer (D-SMC) from other neoplasia. The sensitivity in differentiating neoplasia from non-neoplasia was 98.1%-99.8%. The specificity in differentiating malignant neoplasia from benign neoplasia was 84.7%-98.2% and the specificity in the differentiation D-SMC from other neoplasia was 99.8%-100.0%. This classification would enable endoscopists to identify almost all neoplasia, to appropriately determine whether to perform en bloc resection or not, and to avoid unnecessary surgery. This article is the first review about the diagnostic performance of the JNET classification. Previous reports about the diagnostic performance have all been retrospective single center studies. A large-scale prospective multicenter evaluation study is awaited for the validation. | Daizen Hirata Hiroshi Kashida Mineo Iwatate Tomomasa Tochio Akira Teramoto Yasushi Sano Masatoshi Kudo | 2019 | World Journal of Clinical Cases2019，7，18： | 6 |
| 6 | Narrow-band imaging observation of colorectal lesions using NICE classification to avoid discarding significant lesions显示文摘AIM: To assess the risk of failing to detect diminutive and small colorectal cancers with the 'resect and discard' policy.METHODS: Patients who received colonoscopy and polypectomy were recruited in the retrospective study. Probable histology of the polyps was predicted by six colonoscopists by the use of NICE classification. The incidence of diminutive and small colorectal cancersand their endoscopic features were assessed. RESULTS: In total, we found 681 cases of diminutive(1-5 mm) lesions in 402 patients and 197 cases of small(6-9 mm) lesions in 151 patients. Based on pathology of the diminutive and small polyps, 105 and 18 were non-neoplastic polyps, 557 and 154 were low-grade adenomas, 18 and 24 were high-grade adenomas or intramucosal/submucosal(SM) scanty invasive carcinomas, 1 and 1 were SM deeply invasive carcinoma, respectively. The endoscopic features of invasive cancer were classified as NICE type 3 endoscopically.CONCLUSION: The risk of failing to detect diminutive and small colorectal invasive cancer with the 'resect and discard' strategy might be avoided through the use of narrow-band imaging observation with the NICE classification scheme and magnifying endoscopy. | Santa Hattori Mineo Iwatate Wataru Sano Noriaki Hasuike Hidekazu Kosaka Taro Ikumoto Masahito Kotaka Akihiro Ichiyanagi Chikara Ebisutani Yasuko Hisano Takahiro Fujimori Yasushi Sano | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 5 |
| 7 | Study on the applicability of frequency spectrum of micro-tremor and dynamic characteristics of surface ground in Asia area显示文摘The dynamic characteristics of ground soil using micro-tremor observation in Asia (Zushi and Ogasawara (Japan), Xi’an (China), Manila (Philippines), and Gujarat (India)) are studied. Ground micro-tremor signals were observed and analyzed by fast Fourier transform method (FFT). The response of ground soil to frequency of ground micro-tremor is revealed, and func- tions with frequency-dependence and frequency-selection of micro-tremor for different foundation soil strata are also researched. The horizontal to vertical spectral ratio (H/V, Nakamura technique) of micro-tremor observed at the surface ground was used to evaluate the site’s predominant period. This paper also discusses the application of micro-tremor on site safety evaluation, and gives the observed calculation results obtained at multiple points. The experimental foundation and the deduction process of the method are described in detail. Some problems of the method are pointed out. Potential use of the technique’s good expandable nature makes it a useable means for preventing and reducing disaster’s harmful effects. | CHE Ai-lan IWATATE Takahiro ODA Yoshiya GE Xiu-run | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，11： | 5 |
| 8 | Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)显示文摘AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive polyps.METHODS Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological diagnosis.CONCLUSION Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for 'real-time histopathology'. | Takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito Ichikawa Takahiro Fujimori | 2018 | World Journal of Gastrointestinal Oncology2018，10，4： | 4 |
| 9 | Genetic Parameters for Milk,Fat Yield and Age at First Calving of Chinese Holsteins in Heilongjiang显示文摘Genetic parameters for milk,fat yield and age at first calving of Chinese Holsteins in Heilongjiang were evaluated using multiple trait restricted maximum likelihood procedures with an animal model.Data consisted of records of 2496 Chinese Holsteins first lactation cows collected from 1989 to 2000.The model included 21 herd effects,four calving season effects,nine age at first calving effects,6697 animal effects.(Co)variance components of milk yield,fat yield and age at first calving were estimated with the software package for variance component estimation(VCE) by an animal model. The heritabilities were 0.14,0.21,0.38 for milk yield,fat yield and age at first calving,respectively.The estimates of genetic correlation between milk yield and fat yield,age at first calving were 0.96,-0.29,respectively.The estimate of genetic correlation between fat yield and age at first calving was -0.28. | Ding Ke wei,Takeo Kayaba (The United Graduate School of Agricultural Science,Iwate Uniersity,Morioka Shi,020-8550,Japan) | 2001 | Journal of Northeast Agricultural University(English Edition)2001，8，2： | 2 |
| 10 | Three-dimensional dental cast analyzing system using laser scanning显示文摘 | Kuroda T Motchashi N Tominaga R Iwate K | 1996 | Am J Orthod Dentofacial Orthop1996，110，： | 1 |
| 11 | Geographical distribution of persistent organochlorines in air, water and sediments from Asia and Oceania, and their implications for global redistribution from lower latitudes显示文摘 | IWATE H TANABE S SAKAI N | 1994 | Environmental Pollution1994，85，1： | 1 |
| 12 | Shaking table test and numerical simulation of seismic response of metro structures显示文摘 | CHE A IWATATE T | 2002 | Structures under Shock and Impact Ⅶ2002，11，： | 1 |
| 13 | Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients显示文摘 | Higashimoto Y Yamagata Y Iwat T | 2005 | Eur Respir2005，25，： | 1 |
| 14 | Evaluation of Dynamic Soil-Structure Interaction and Dynamic Seismic Soil Pressures Acting on It Subjected to Strong Earthquake Motions显示文摘In order to clarify the damage mechanism of the subway structure, the dynamic soil-structure interaction and the dynamic forces acting on the structure, a series of shaking table tests and simulation analyses were performed. The seismic response of the structure and the dynamic forces acting on the structure due to sinusoidal and random waves were investigated with special attention to the dynamic soil-structure interaction. The result shows that the compression seismic soil pressures and extension seismic soil pressures simultaneously act on the sidewalls, and big shear stress also acts on the ceiling slab due to horizontal excitation. The seismic soil pressure could be approximated to hyperbola curve, and reached a peak value with increase of the shear strain of the model ground. In addition, a slide and exfoliation phenomenon between the structure and the surrounding ground was simulated, using the nonlinear analyses. The foundation is provided for amending the calculation method of seismic soil pressure and improving the anti-earthquake designing level of underground structure. | 车爱兰 IWATATE Takahiro 葛修润 | 2006 | Journal of Shanghai Jiaotong university(Science)2006，11，4： | 1 |
| 15 | Renal tubular function of environment cadmium exposure ten-year follow- up显示文摘 | Kokichi Iwat Hiroshi Saito Moriyama | 1993 | Archives of Environmental Health1993，48，3： | 1 |
| 16 | Shaking Table Test and Numerical Simulation of Seismic Response of Metro Structures显示文摘 | CHA A IWATATE T | 2002 | Structures under Shock and Impact Ⅶ2002，11，： | 1 |
| 17 | Staphylococcal cutaneous infections , invasion , evasion and aggression显示文摘 | Iwat suki K Yamasaki O Morizane S | 2006 | Dermatol Sci2006，42，3： | 1 |
| 18 | Effects of in vivo gene transfer of fibroblast growth factor-2 on cardiac function and collateral vessel formation in the microembolized rabbit heart显示文摘 | Iwatate M Miura T Ikeda Y | 2001 | Jap Circ2001，3，65： | 1 |
| 19 | Single crystal growth of GaN using a Ga melt in Na vapor 显示文摘 | Takahiro Yamada Hisanori Yamane Hirokazu Iwat et a l | 2005 | Journal of Crystal Growth2005，，281： | 1 |
| 20 | 19F and ^1H MRI detection of amyloid β plaques in vivo 显示文摘 | Makoto Higuehil Nobuhisa Iwatal Yukio Matsubal | 2005 | Nature neuroscience2005，8，4： | 1 |
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