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| 1 | Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures显示文摘我们试图在有一般麻药 transperineal (TP ) 的男人决定短期的报导病人的结果前列腺活体检视。未来的队研究在有诊断 TP 活体检视的男人被执行。这用立即活体检视以后的一张验证并且适应的问询表并且在后续被做在越过三个第三级的工作分派的 7 和 14 天之间,有回答的医院 51.6% 评价。立即,在活体检视以后,人的 43/201 (21.4%) 感觉到头昏眼花, syncopal,或承受中略。百分之 53 个人在活体检视以后感到了不快(与 95% 得分 < 5 在 0-10 规模) 。12 在过程以后立即从 196 个人(6.1%) 感到了疼痛。尽管有症状的高发生(例如直到 75% 有的一些血尿症, 47% 得了一些疼痛) ,它不是为大多数的一个中等或严重的问题,除了 31 个人承受了的 hemoejaculate。十一个人需要 catheterization (5.5%) 。由于复杂并发症没有住院病人录取(血尿症,败血) 。在重复在一个以后的时间点询问以后,仅仅人的 25/199 (12.6%) 说尽管有重要、显著的减小,重复活体检视将是一个重要问题。从这研究,我们断定那 TP 活体检视很好与类似的副作用侧面和人的态度被容忍重复活体检视到有 TRUS 活体检视的人。这些数据给予与局部麻醉 TP 活体检视为 tolerability 在 TP 活体检视和一个基准以前人建议通知为临床的使用正在被开发。 | Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 2 | Enzyme extraction, functional properties and application of leaf protein frac- tions of nettle 显示文摘 | Pencho Dalev Anna Wubomirova Ivailo Ivanov | 1996 | Blotechnology Letters1996，18，1： | 1 |
| 3 | Serviee Gateway Architecture for a Smart Home显示文摘 | Dimitar Valtchevand Ivailo Frankov | 2002 | IEEECommunications Magazine2002，4，： | 1 |
| 4 | Prevalence of HBV and HCV among outpatients in the plovdiv region of Bulgaria, 2010–2011显示文摘 | Ani Kevorkyan Pavel Teoharov Tinne Lernout Nedyalka Petrova Ralitsa Raycheva Ivailo Ivanov Pierre van Damme Mira Kojouharova | 2015 | Virol2015，，3： | 1 |
| 5 | Mayaro virus infection, the next epidemic wave after Zika?Evolutionary and structural analysis显示文摘Objective: To evaluate the evolution of the pathogen Mayaro virus, causing Mayaro fever(a mosquito-borne disease) and to perform selective pressure analysis and homology modelling.Methods: Nine different datasets were built, one for each protein(from protein C to non-structural protein 4) and the last one for the complete genome. Selective pressure and homology modelling analyses were applied. Results: Two main clades(A and B) were pointed in the maximum likelihood tree. The clade A included five Brazilian sequences sampled from 1955 to 2015. The Brazilian sequence sampled in 2014 significantly clustered with the Haitian sequence sampled in 2015. The clade B included the remaining 27 sequences sampled in the Central and Southern America from 1957 to 2013. Selective pressure analysis revealed several sites under episodic diversifying selection in envelope surface glycoprotein El, non-structural protein 1 and nonstructural protein 3 with a posterior probability P≤0.01. Homology modelling showed different sites modified by selective pressure and some protein-protein interaction sites at high interaction propensity. Conclusion: Maximum likelihood analysis confirmed the Mayaro virus previous circulation in Haiti and the successful spread to the Caribbean and USA. Selective pressure analysis revealed a strong presence of negatively selected sites, suggesting a probable purging of deleterious polymorphisms in functional genes. Homology model showed the position 31, under selective pressure, located in the edge of the ADP-ribose binding site predicting to possess a high potential of protein-protein interaction and suggesting the possible chance for a protective vaccine,thus preventing Mayaro virus urbanization as with Chikungunya virus. | Eleonora Cella Marta Giovanetti Teresa Milano Marta Fogolari Francesco Garilli Ivailo Alexiev Riccardo Bazzardi Marco Salemi Luiz Carlos Junior Alcantara Silvia Angeletti Stefano Pascarella Massimo Ciccozzi | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，3： | 0 |
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