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您的检索式：作者名="Ismail Labgaa"
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| 1 | Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy显示文摘AIM To identify a preoperative blood marker predictive of alveolar echinococcosis(AE) recurrence after hepatectomy.METHODS All consecutive patients who underwent operation for liver AE at the Lausanne University Hospital(CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume(MCV), red blood cell distribution width(RDW), thrombocytes, C-reactive protein(CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic(ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrencefree survival curves were calculated using the KaplanMeier method.RESULTS The cohort included 68 adult patients(37 females) with median age of 61 years [interquartile range(IQR): 46-71]. Eight of the patients(12%) presented a recurrence over a median follow-up time of 76 mo(IQR: 34-128). Median time to recurrence was 10 mo(IQR: 6-11). Median preoperative leukocyte, MCV, RDW,thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/L(IQR: 41-45) for nonrecurrent cases and 36 g/L(IQR: 33-42) for recurrent cases(P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840(95%CI: 0.642-1, P = 0.002). The cutoff albumin level value was 37.5 g/L for sensitivity of 94.5% and specificity of 75%. In multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence(HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively).CONCLUSION Low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up. | Gaetan-Romain Joliat Ismail Labgaa Nicolas Demartines Nermin Halkic | 2017 | World Journal of Gastroenterology2017，23，5： | 1 |
| 2 | Gallbladder volvulus显示文摘Background Like colon or stomach,gallbladder can twist,leading to a volvulus;an entity first described by Wendel in 1898(1).Gallbladder volvulus(GV)is a relatively rare disease occurring when the gallbladder rotates on its own axis,along the cystic duct(Figure 1).Different types of rotation have been described:incomplete vs.complete(≤180°vs.>180°)and clockwise vs.anticlockwise(2).As the rotation might involve the cystic artery,blood supply may be compromised,resulting in ischemia and eventually necrosis.GV constitutes an acute abdominal condition associated with poor outcomes,if not diagnosed and treated in time. | Laureline Moser Gaëtan-Romain Joliat Parissa Tabrizian Luca Di Mare David Petermann Nermin Halkic Nicolas Demartines Ismail Labgaa | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 0 |
| 3 | International assessment and validation of the prognostic role of lymph node ratio in patients with resected pancreatic head ductal adenocarcinoma显示文摘Background:Lymph node ratio(LNR;positive/harvested lymph nodes)was identified as overall survival predictor in several cancers,including pancreatic adenocarcinoma.It remains unclear if LNR is predictive of overall survival in pancreatic adenocarcinoma patients staged pN2.This study assessed the prognostic overall survival role of LNR in pancreatic adenocarcinoma patients in relation with lymph node involvement.Methods:A retrospective international study in six different centers(Europe and United States)was performed.Pancreatic adenocarcinoma patients who underwent pancreatoduodenectomy from 2000 to 2017 were included.Patients with neoadjuvant treatment,metastases,R2 resections,or missing data regarding nodal status were excluded.Survival curves were calculated using Kaplan-Meier method and compared using log-rank test.Multivariable Cox regressions were performed to find independent overall survival predictors adjusted for potential confounders.Results:A total of 1,327 patients were included.Lymph node involvement(pN+)was found in 1,026 patients(77%),561 pN1(55%)and 465 pN2(45%).Median LNR in pN+patients was 0.214[interquartile range(IQR):0.105-0.364].On multivariable analysis,LNR was the strongest overall survival predictor in the entire cohort[hazard ratio(HR)=5.5;95%confidence interval(CI):3.1-9.9;P<0.001]and pN+patients(HR=3.8;95%CI:2.2-6.6;P<0.001).Median overall survival was better in patients with LNR<0.225 compared to patients with LNR≥0.225 in the entire cohort and pN+patients.Similar results were found in pN2 patients(worse overall survival when LNR≥0.225).Conclusions:LNR appeared as an important prognostic factor in patients undergoing surgery for pancreatic adenocarcinoma and permitted to stratify overall survival in pN2 patients.LNR should be routinely used in complement to tumor-node-metastasis(TNM)stage to better predict patient prognosis. | Gaetan-Romain Joliat Ismail Labgaa Jesse Sulzer Dionisios Vrochides Alessandro Zerbi Gennaro Nappo Julie Perinel Mustapha Adham Stijn van Roessel Marc G.Besselink JSven D.Mieog Jesse V.Groen Nicolas Demartines Markus Schafer | 2022 | Hepatobiliary Surgery and Nutrition2022，11，6： | 0 |
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