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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Ultraviolet DIAL measurements of 03 profiles in regions of spatially inhomogeneous aerosols 显示文摘 | Browell E V Ismail S Shipley S T | 1985 | Applied Optics1985，24，17： | 1 |
| 3 | Purification and a dehydrin involved in chilling tolerance during seedling emergence of cowpea 显示文摘 | Ismail A M Hall A E Close T partial characterization of Sequence and their Biology J | 1999 | Plant Physiology1999，120，1： | 1 |
| 4 | Natural fibre high- density polyethylene and lead oxide composites for radi- ation shielding 显示文摘 | Abdo A E Ali M A M Ismail M R | 2003 | Radiation Physics and Chemistry2003，66，3： | 1 |
| 5 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 6 | DeterminaTion of flavonoid and phenolic acid contents of clover,cotton and citrus floral honeys显示文摘 | HAMDY A A ISMAIL H M aI-AHWAL A E A | 2009 | J Egypt Public Health Assoc2009，84，34： | 1 |
| 7 | Effect of additives concentration on the surface properties and performance of PVDF ultraflltration membranes for refinery produced wastewater treatment 显示文摘 | E Yuliwati A F Ismail | 2011 | Desalination2011，273，1： | 1 |
| 8 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 9 | Fuzzy clustering for symbolic data显示文摘 | Sonbaty Y E Ismail M A | 1998 | IEEE Fuzzy Systems1998，6，2： | 1 |
| 10 | Biodetrimental effects of the Corn hybrids, Neemazal - T/S and Chlorphan 48% on the pink corn borer Sesamia eretiea Led 显示文摘 | ISMAIL I A ABDEL - MONIEM A S H EL - SHAZLY E A | 2012 | Archives of Phytopathology And2012，45，17： | 1 |
| 11 | Use o{ plastic waste in concrete mixture as aggregate replacement显示文摘 | Ismail Z Z A1-Hashmi E A | 2008 | Waste Manage2008，28，： | 1 |
| 12 | The chemical composition of the juice and seeds of pomegranate fruits 显示文摘 | EI-Nemr S E Ismail I A Ragab M | 1992 | Fluessiges Obst (Fruit Processing)1992，9，11： | 1 |
| 13 | 源自天然席夫碱的过渡金属配合物在分光光度法测天然水中的Fe(Ⅲ)的应用(英文)显示文摘描述了一种新颖、简便的合成含五齿配位基的大环席夫碱配体的方法,制备和表征了该席夫碱的1∶1包合物。用化学和光谱学方法测定了标题配合物的组成,认为在所有配合物中配位金属原子取八面体结构。数据表明:配体起O2N4六齿结构而每个环绕金属原子在八面体环境中。配合物的红外和1H NMR光谱符合中心金属原子的配位结果。用分光光度法测定了配合物的稳定常数。用共轭余量法(CR method)计算了在热分解的不同阶段配合物活化的动力学和热力学参数。此外,用抑菌圈直径法筛选了配体及其金属配合物抑制细菌和真菌的能力。用回收率试验研究了天然螯合配体在不同天然水体中对Fe(Ⅲ)离子配合作用的影响。 | Khalil M M H Mohamed G G Ismail E H Zayed M E Kamel B A | 2012 | 无机化学学报2012，28，7： | 1 |
| 14 | Effect of modified PVDF hollow fiber submerged ultrafiltration membrane for refinery wastewater treatment 显示文摘 | Yuliwati E Ismail A F Matsuura T Kassim M A Abdullah M S | 2011 | Desalination2011，283，： | 1 |
| 15 | Morpho-tectonic analysis of the Tekeze River and the Blue Nile drainage systems on the Northwestern Plateau, Ethiopia显示文摘 | ISMAIL E H ABDELSALAM M G | 2012 | Journal of African earth sciences2012，69，： | 1 |
| 16 | Cure and tear properties of ENR--25/ SMR--L and SMR--L blends显示文摘 | Ismail H Poh E T | 2000 | European Polymer Journal2000，36，11： | 1 |
| 17 | A review of the association between depression and insulin resistance: pitfalls of seconda- ry analyses or a promising new approach to prevention of type 2 diabetes? 显示文摘 | SILVA N ATLANTIS E ISMAIL K | 2012 | Curt Psychiatry Rep2012，14，1： | 1 |
| 18 | Relation between carotid inti- ma-media thickness, platelet surface activation and endothelial cell markers 显示文摘 | Ramsis N E1-Hawary AA Ismail E | 1998 | Haemostasis1998，28，5： | 1 |
| 19 | Fatigue, resilience and hardness properties of ENR--25/SMR--L and SMR--L blends显示文摘 | Poh E T Ismail H | 2001 | Polymer testing2001，20，5： | 1 |
| 20 | Large step-down DC-DC converters with reduced current stress显示文摘 | ISMAIL E H | 2009 | Energy Conversion and Management2009，50，2： | 1 |
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