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| 1 | What is the relationship between frailty and orthostatic hypotension in older adults?显示文摘Background Frailty and orthostatic hypotension (OH),which is common in older adults,is associated with morbidity and mortality.The relationship between them remains unclear.The aim of the study is to determine whether there is a relationship between frailty and OH.Methods A total of 496 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were retrospectively reviewed.In a cross-sectional and observational study,OH was measured by the Head-up Tilt Table test at 1,3,and 5 min (respectively,OH1,OH3,and OH5) and the frailty was measured by the Fried’s frailty scale.Results The mean age of all patients was 75.4 ± 7.38.The prevalence of females was 69.8%.When the frail people were compared with the pre-frail and the robust ones,the frailty was associated with OH1.There was no relationship between the groups in terms of OH1 when the pre-frail group was compared with the robust group.OH3 were higher in the frail group than in the pre-frail group (P < 0.05) and the OH5 were higher in the frail group than in the pre-frail and robust group (P < 0.05),but OH3 and OH5 were not associated with frailty status when they were adjusted for age (P > 0.05).Slowness and weakness were associated with OH1 (P < 0.05),whereas the other components of the Fried’s test were not.Conclusions Frailty may be a risk factor for OH1.The 1^st min measurements of OH should be routinely evaluated in frail older adults to prevent OH-related poor outcomes. | Suleyman Emre Kocyigit Pinar Soysal Esra Ates Bulut Ali Ekrem Aydin Ozge Dokuzlar Ahmet Turan Isik | 2019 | Journal of Geriatric Cardiology2019，16，3： | 3 |
| 2 | Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia显示文摘AIM: To evaluate the risk factors leading to recurrence in patients with ocular surface squamous neoplasia(OSSN)METHODS: The records of 112 patients with OSSN who underwent treatment and follow-up between February 1999 and August 2018 were reviewed retrospectively.RESULTS: Totally 67 patients(59.8%) were male and 45 patients(40.2%) were female. The mean age at presentation was 63.7 y(range 22-87 y). Partial lamellar scleroconjunctivectomy(PLSC) was performed in 105(93.7%) cases and enucleation was performed in 7(6.3%) cases due to bulbus invasion as the first step treatment. Treatments used in addition to PLSC included cryotherapy in 78 eyes(74.3%), alcohol epitheliectomy in 57 eyes(54.3%) for presence of corneal involvement, and amniotic membrane transplantation in 17 eyes(16.2%) for ocular surface reconstruction. Topical mitomycin C was used in 10 patients(9.5%) and strontium-90(Str-90) treatment in 4(3.8%) patients because surgical margins were tumor positive at the histopathological examination. Postoperative histopathologic diagnoses were squamous cell carcinoma(52 cases), carcinoma in situ(44 cases), moderate conjunctival intraepithelial neoplasia(11 cases), and mild conjunctiva intraepithelial neoplasia(5 cases). At a mean follow-up of 20.1 mo, tumor recurrence was observed in 21(18.8%) cases. The rate of recurrence was found to be lower in cases that underwent supplemental cryotherapy compared to those that did not(P<0.001). There was no metastasis in any case. CONCLUSION: In our series, the recurrence rate is 18.8% and overall globe salvage rate is 90.2% for OSSN at relatively short-term follow-up. | Ibadulla Mirzayev Ahmet Kaan Gunduz Funda Seher Ozalp Ates Gokcen Ozcan Mehmed Ugur Isik | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 3 | Cardiac safety of donepe- zil in elderly patients with Alzheimer disease显示文摘 | Isik AT Yildiz GB Bozoglu E | 2012 | Intern Med2012，51，6： | 1 |
| 4 | Evaluation of the effects of galantamine on cardiac function in elderly patients with alzheimer' s disease 显示文摘 | Isik AT Bzoglu E Naharci MI | 2010 | Am J Geriatr Pharmacother2010，8，5： | 1 |
| 5 | Metformin in the treatment of patients with non-alcoholic steatohepatitis显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharmacol Ther2004，19，： | 1 |
| 6 | Metformin in the treatment of patients with non-alcoholic steatohepatitis显示文摘 | Uygun A Kadayifci A Isik AT | | 0，，05： | 1 |
| 7 | Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis显示文摘 | Ceylan Isik AF Zhao P Zhang B et at | 2010 | J Mol Cell Cardiol2010，48，2： | 1 |
| 8 | Metformin in the treatment of patients with non-alcoholic steatohepatitis显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Phamacol Ther2004，19，5： | 1 |
| 9 | Metformin in thetreatment of patients with non-alcoholic steatohepatitis 显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharmacol Ther2004，19，5： | 1 |
| 10 | Metformin in the treatment of patients with non-alcoholic steatohepatitis 显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharmacol Ther2004，19，5： | 1 |
| 11 | Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease显示文摘 | Ulusoy GK Celik T Kayir H Gürsoy M Isik AT Uzbay TI | 2011 | Brain Res Bull2011，85，6： | 1 |
| 12 | Mefformin in thetreatment of patients with non-alcoholic steatohepatitis显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharulacol Ther2004，19，5： | 1 |
| 13 | The effect of combination therapy of hyperbaric oxygen, meropenem, and selective nitric oxide synthase inhibitor in experimental acute pancreatitis显示文摘 | Isik AT Mas MR Comert B | 2004 | Pancreas2004，28，1： | 1 |
| 14 | Metformin in the treatment of patients with non-alcoholic steatohepatitis显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharulacol Ther2004，19，： | 1 |
| 15 | Metformin in the treatment of patients with non-alcoholic steatohepatitis 显示文摘 | UYGUN A KADAYIFCI A ISIK AT | 2004 | Ali- ment Pharmacol Ther2004，19，5： | 1 |
| 16 | Metformin in the treatment of patients with non-alcoholicsteatohepatitis 显示文摘 | Uygun A Kadayifci A Isik AT | 2004 | Aliment Pharmacol Ther2004，19，5： | 1 |
| 17 | Effects of infliximab on bacterial translocation in experimental acute neerotizing pancreatitis显示文摘 | Aydin S Isik AT Unal B | 2012 | Indian J Med Res2012，135，5： | 1 |
| 18 | Antioxidant treatment with taurine ameliorates chronic pancreatitis in an experimental rat model显示文摘 | Mas MR Isik AT Yamanel L | 2006 | Pancreas2006，33，1： | 1 |
| 19 | Mefformin in the treatment of pa-tients with non-alcoholic steatohepatitis显示文摘 | Kadayifei A Isik At | 2004 | Aliment Pharmacol Ther2004，19，： | 1 |
| 20 | Metformin in the treatment of patients with non-alcoholic steatohepatitis 显示文摘 | Uygun A Kadayifcia Isik AT | 2004 | Aliment Pharmacol Ther2004，19，： | 1 |
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