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| 1 | Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra显示文摘 | ISIDRO FERRER ANNA MARíA PLANAS | 2003 | JNEN: Journal of Neuropathology & Experimental Neurology2003，，： | 1 |
| 2 | Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra显示文摘 | ISIDRO FERRER ANNA MARíA PLANAS | 2003 | JNEN: Journal of Neuropathology & Experimental Neurology2003，，4： | 1 |
| 3 | Ecto-GPR37:a potential biomarker for Parkinson’s disease显示文摘Objective:a-Synuclein has been studied as a potential biomarker for Parkinson's disease(PD)with no concluding results.Accordingly,there is an urgent need to find out reliable specific biomarkers for PD.GPR37 is an orphan G protein-coupled receptor that toxically accumulates in autosomal recessive juvenile parkinsonism.Here,we investigated whether GPR37 is upregulated in sporadic PD,and thus a suitable potential biomarker for PD.Methods:GPR37 protein density and mRNA expression in postmortem substantia nigra(SN)from PD patients were analysed by immunoblot and RT-qPCR,respectively.The presence of peptides from the N-terminus-cleaved domain of GPR37(i.e.ecto-GPR37)in human cerebrospinal fluid(CSF)was determined by liquid chromatography-mass spectrometric analysis.An engineered in-house nanoluciferase-based immunoassay was used to quantify ecto-GPR37 in CSF samples from neurological control(NC)subjects,PD patients and Alzheimer's disease(AD)patients.Results:GPR37 protein density and mRNA expression were significantly augmented in sporadic PD.Increased amounts of ecto-GPR37 peptides in the CSF samples from PD patients were identified by mass spectrometry and quantified by the in-house ELISA method.However,the CSF total a-synuclein level in PD patients did not differ from that in NC subjects.Similarly,the cortical GPR37 mRNA expression and CSF ecto-GPR37 levels in AD patients were also unaltered.Conclusion:GPR37 expression is increased in SN of sporadic PD patients.The ecto-GPR37 peptides are significantly increased in the CSF of PD patients,but not in AD patients.These results open perspectives and encourage further clinical studies to confirm the validity and utility of ecto-GPR37 as a potential PD biomarker. | Xavier Morato Paula Garcia-Esparcia Josep Argerich Franc Llorens Inga Zerr Wojciech Paslawski Eva Borras Eduard Sabido Ulla EPetaja-Repo Victor Fernandez-Duenas Isidro Ferrer Per Svenningsson Francisco Ciruela | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 4 | Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice显示文摘 | Agustín Rodríguez Esther Pérez-Gracia Juan Carlos Espinosa Martí Pumarola Juan María Torres Isidro Ferrer | 2006 | Acta Neuropathologica2006，，5： | 1 |
| 5 | 奇异的编织装置——大象落地灯ELEPHANT显示文摘坐标:
西班牙
La LZF Lamps,是西班牙一家专业生产薄木片灯具的公司,其作品是在意大利米兰国际灯展上展出的新的合作灯具系列。这一雕刻灯具系列来自于LZF Lamp公司Isidro Ferrer的合作,是艺术家和工匠展开跨领域的协作与突破创新的成果。 | Isidro Ferrer 高红 Santiago Relanzón | 2017 | 国际纺织品流行趋势2017，0，1： | 0 |
| 6 | 嘿,我们是一组诗显示文摘长了一双腿的鱼、只有四只脚的蚂蚁、没了尾巴的猴子……这是一个奇特的动物园。不仅如此,它们的面部表情被简略成加号、减号、除号,有些甚至只剩一个圆点。它们身体的形状更是千奇百怪,像漏斗、圆柱,甚至章鱼。当你迫不及待地想嘲笑它们如此呆萌、奇特时,它们却能有力地回击你:嘿!我们是一组诗。 | 青桑 Isidro Ferrer | 2016 | 中华手工2016，0，5： | 0 |
| 7 | Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer’s disease显示文摘Background:New fuid biomarkers for Alzheimer’s disease(AD)that reveal synaptic and neural network dysfunc‑tions are needed for clinical practice and therapeutic trial design.Dense core vesicle(DCV)cargos are promising cerebrospinal fuid(CSF)indicators of synaptic failure in AD patients.However,their value as biomarkers has not yet been determined.Methods:Immunoassays were performed to analyze the secretory proteins prohormone convertases PC1/3 and PC2,carboxypeptidase E(CPE),secretogranins SgIII and SgII,and Cystatin C in the cerebral cortex(n=45,provided by Bellvitge University Hospital)and CSF samples(n=66,provided by The Sant Pau Initiative on Neurodegeneration cohort)from AD patients(n=56)and age-matched controls(n=55).Results:In AD tissues,most DCV proteins were aberrantly accumulated in dystrophic neurites and activated astro‑cytes,whereas PC1/3,PC2 and CPE were also specifcally accumulated in hippocampal granulovacuolar degeneration bodies.AD individuals displayed an overall decline of secretory proteins in the CSF.Interestingly,in AD patients,the CSF levels of prohormone convertases strongly correlated inversely with those of neurodegeneration markers and directly with cognitive impairment status.Conclusions:These results demonstrate marked alterations of neuronal-specifc prohormone convertases in CSF and cortical tissues of AD patients.The neuronal DCV cargos are biomarker candidates for synaptic dysfunction and neurodegeneration in AD. | Neus Barranco Virginia Plá Daniel Alcolea Irene Sánchez‑Domínguez Reiner Fischer‑Colbrie Isidro Ferrer Alberto Lleó Fernando Aguado | 2021 | Translational Neurodegeneration2021，10，3： | 0 |
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