|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | Adaptive on-line steady-state optimization of slow dynamic processes显示文摘 | Bamrerger W Isermann R | 1978 | Automatica1978，14，： | 2 |
| 3 | Modeling and Real-Time Simulation of Diesel Engines for Control Design显示文摘 | Sinsel Stefan Schaffnit Jochen | 1998 | SAE Special Publications1998，1357，： | 1 |
| 4 | Trends in the application of' model-based fault detections and diagnosis of technical processes 显示文摘 | ISERMANN R BALLE P | 1997 | Control Eng Practice1997，5，5： | 1 |
| 5 | Design of computer controlled combustion engines 显示文摘 | Rolf Isermann Norbert Muller | 2003 | Mechatronics2003，，13： | 1 |
| 6 | Endothelium specific loss of murine t hrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile - onset thrombosis 显示文摘 | ISERMANN B HENDRICKSON S B ZOGG M | 2001 | Clin Invest2001，108，： | 1 |
| 7 | Share of agriculture in nitrogen and phosphorus emissions into the surface waters of Western-Europe against the background of their eutrophication 显示文摘 | Isermann K | 1990 | Fertilizer Research1990，26，13： | 1 |
| 8 | Design of computer controlled combustion engines显示文摘 | R Isermann and N Mtieller | 2003 | Mechatronics2003，13，10： | 1 |
| 9 | Model-based fault-detection and diagno- sis-status and applications显示文摘 | ISERMANN R | 2005 | Annual Reviews in Con- trol2005，29，1： | 1 |
| 10 | Peripheral blood monomuclear cells isolated from patients with diabetic nephropathy show incressed activation of the oxidative stress sensitive transcription factor NF-kB显示文摘 | Hofmann MA Schiekofer S Isermann B | 1999 | Diabetologia1999，42，： | 1 |
| 11 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative stress sensitive transcription factor NF-кB显示文摘 | Hofmann M A Schiekofer S Isermann B | 1999 | Diabetologia1999，42，2： | 1 |
| 12 | Peripheral blood mononuclear cells isolated from patients with increased activation of the transcription factor NF-kappa B 显示文摘 | Hofmann M A Schiekofer S Isermann B | 1999 | Diabetologia1999，42，： | 1 |
| 13 | Food production and consumptionin Germany: N flows and emissions显示文摘 | Isermann K Isermann R | 1998 | Nutrient Cycling Agroecosystem1998，52，23： | 1 |
| 14 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcrip- tion factor NF-kappa B 显示文摘 | Hofmann MA Schiekofer S Isermann B | 1999 | Diabetologia1999，42，2： | 1 |
| 15 | Adaptive predictive control of a heat exchanger based on a fuzzy model显示文摘 | Fisher M Nelles O Isermann R | 1998 | Control Engineering Practice1998，6，25： | 1 |
| 16 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB显示文摘 | Hofmann M A Schierkofer S Isermann B | 1999 | Diabetologia1999，42，： | 1 |
| 17 | On fuzzy logic applications for automatic control, supervision, and fault diagnosis显示文摘 | Isermann R | 1998 | IEEE Trans Systems Man and Cybernetics-Part A1998，28，2： | 1 |
| 18 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappa B显示文摘 | Holfmann MA Schiekofer S Isermann B | 1999 | Diabetologia1999，42，： | 1 |
| 19 | Supervision of nonlinear adaptive controllers based on fuzzy models 显示文摘 | Fink A Fischer M Nelles O Isermann R | 2000 | Control Engineering Practice2000，8，10： | 1 |
| 20 | Adaptive on-line steady-state optimization of slow dynamic processes显示文摘 | BAMBERGER W ISERMANN R | 1978 | Automatica1978，14，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员