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| 1 | Small bowel capsule endoscopy in patients with cardiac pacemakers and implantable cardioverter defibrillators:Outcome analysis using telemetry review显示文摘AIM:To determine if there were any interactions between cardiac devices and small bowel capsules secondary to electromagnetic interference (EMI) in patients who have undergone small bowel capsule endoscopy (SBCE).METHODS:Authors conducted a chart review of 20 patients with a cardiac pacemaker (CP) or implantable cardioverter defibrillator (ICD) who underwent continuous electrocardiographic monitoring during their SBCE from 2003-2008.authors searched for unexplained electrocardiogram (ECG) findings,changes in CP andICD set parameters,any abnormality in transmitted capsule data,and adverse clinical events.RESULTS:There were no adverse events or hemodynamically significant arrhythmias reported.CP and ICD set parameters were preserved.The majority of ECG abnormalities were also found in pre-or post-SBCE ECG tracings and the CP behavior during arrhythmias appeared appropriate.Two patients seemed to have episodes of undersensing by the CP.However,similar findings were documented in ECGs taken outside the time frame of the SBCE.One patient was observed to have a low signal encountered from the capsule resulting in lack of localization,but no images were lost.CONCLUSION:Capsule-induced EMI remains a possibility but is unlikely to be clinically important.CPinduced interference of SBCE is also possible,but is infrequent and does not result in loss of images transmitted by the capsule. | Justin R Cuschieri Mohammed N Osman Richard CK Wong Amitabh Chak Gerard A Isenberg | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 6 |
| 2 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 3 | Asthma and emotion:a review显示文摘 | Lehrer PM Isenbergs A Hochron SM | 1993 | Asthma1993，30，： | 2 |
| 4 | The effect of interleukin-10 and of interleukin-12 on the in vitro production of anti-double-stranded DNA antibodies from patients with systemic lupus erythematosus 显示文摘 | Tyrrell-Price J Lydyard P M Isenberg D A | 2001 | Clin Exp Immunol2001，124，1： | 2 |
| 5 | Outcomes and complications of elastic stable intramedullary nailing for forearm fractures in children显示文摘 | Jubel A Andermahr J Isenberg J | 2005 | Journal of Pediatric Orthopaedics B2005，14，5： | 1 |
| 6 | Treatment of polymyositis and dermaomyositis显示文摘 | Kaye S A Isenberg D A | 1994 | Br Hos J Med1994，52，9： | 1 |
| 7 | Early treatment with rituximab in newly diagnosed systemic lupus erythematosus patients: a steroid-sparing regimen显示文摘 | Ezeonyeji A N Isenberg D A | 2012 | Rheumatology (Oxford)2012，51，3： | 1 |
| 8 | Does prophylactic pancreatic stent placement reduce the risk Of post-ERCP acute pancreatitis? A meta-analysis Of controlled trials 显示文摘 | SinghP Das A Isenberg G | 2004 | Gastrointest Endosc2004，60，4： | 1 |
| 9 | Interleukin 6 activates heat shock protein 90B gene expression 显示文摘 | Stephanou A Amin B Isenberg DA | 1997 | Biochem J1997，，： | 1 |
| 10 | R/C structures under impulsive loading显示文摘 | Ghabossi J Millavec W A Isenberg J | 1984 | Journal of Structural Engineering1984，110，3： | 1 |
| 11 | Interleukin 6 activates heat-shock protein 90β gene expression显示文摘 | AMIN V ISENBERG D A | 1997 | Biochem J1997，321，1： | 1 |
| 12 | Cardiac fibroblasts and the mechano-electric feedback mechanism in healthy and diseased hearts显示文摘 | Kamkin A Kiseleva I Isenberg G | 2003 | Prog Biophys Mol Biol2003，82，13： | 1 |
| 13 | Systemic lupus erythematosus显示文摘 | Rahman A Isenberg DA | 2008 | N Ensl J Med2008，358，9： | 1 |
| 14 | Outcomes and complica-lions of elastic stable intramedullary nailing for forearm fractures inchildren显示文摘 | Jubel A Andermahr J Isenberg J | | 0，，05： | 1 |
| 15 | The chemical biology of nitric oxide: Implications in cellu- lar signaling显示文摘 | Douglas D T Ridnour L A Isenberg J S | 2008 | Free Radical Biol Med2008，45，1： | 1 |
| 16 | BILAG-2004 Index captures SLE disease activity better than SLEDAI-2000 显示文摘 | YEE C S ISENBERG D A PRABU A et al | 2008 | Ann Rheum Dis2008，67，6： | 1 |
| 17 | Raised levels of interleukin-6 in systemic lupus erythematosus correlate with anemia显示文摘 | GONCALVES B ISENBERG D A | 2005 | Ann Rheum Dis2005，64，6： | 1 |
| 18 | Mechanisms of disease:systemic lupus erythematosus显示文摘 | Rahman A Isenberg D A | 2008 | N Engl J Med2008，358，： | 1 |
| 19 | A review of gastrointestinal manifesta-tions of systemie lupus erythematosus显示文摘 | Sultan S M Ioannou Y Isenberg D A | 1999 | Rhetmmtology1999，38，10： | 1 |
| 20 | Color improves object recognition in normal and low vision 显示文摘 | ISENBERG G WURM L LUBEKER A | 1993 | Jounal of Experimental Psychology: Human Perception and Performance1993，19，： | 1 |
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