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| 1 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 4 | Effect of cortical cooling on interictal epileptiform activities显示文摘 | Ablah E Tran M P Isaac M | 2009 | Seizure2009，18，1： | 1 |
| 5 | Class Ⅲ beta-tubulin expression in tumor cells predicts response and outcome in patients with nonsmall cell lung cancer receiving paclitaxel显示文摘 | Seve P Mackey J Isaac S | 2005 | Mol Cancer Ther2005，4，12： | 1 |
| 6 | Pulmonary blasto- ma:a rare childhood malignancy显示文摘 | Senac M O Jr Wood B P Isaacs H | 1991 | Radiology1991，179，3： | 1 |
| 7 | Role of calcium in the programmed death of rat prostatic glandular cells显示文摘 | Martikainen P Isaacs J | 1990 | Prostate1990，17，3： | 1 |
| 8 | Endoscopic anatomy of the pterygopalatine fossa显示文摘 | Isaacs SJ Goyal P | 2007 | Am J Rhinol2007，21，5： | 1 |
| 9 | Functional lymphocyte subset assessment of the Thl/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes显示文摘 | Colin IM Isaac J Dupret P | 2004 | J Biol Regul Homeost Agents2004，1，1： | 1 |
| 10 | Expression of class Ⅲ { beta }-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy显示文摘 | Seve P Isaac S Tredan O | 2005 | Clin Cancer Res2005，11，15： | 1 |
| 11 | Improving purchasing productivity at IBM with a normative decision support system显示文摘 | Bender P S Brown R W Isaac H | 1985 | Interfaces1985，15，： | 1 |
| 12 | Expression of class Ⅲ {beta}-tu- bulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy 显示文摘 | Seve P Isaac S Tredan O | 2005 | Clin Cancer Res2005，11，15： | 1 |
| 13 | Removal of lead and cadmium ions from water using annona squamosa shell: Kinetic and equilibrium studies显示文摘 | Isaac C P J Sivakumar A | 2013 | Desalination and Water Treat- ment2013，51，40： | 1 |
| 14 | Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy 显示文摘 | Dumontet C Isaac S Souquet P J | 2005 | Bull Cancer2005，92，2： | 1 |
| 15 | MMCs for automotive engine applications显示文摘 | Isaacs J A Clark J P | 1996 | JOM1996，48，2： | 1 |
| 16 | Random amplified polymorphic DNA (RAPD)markers for genetic analysis in Allium 显示文摘 | Wilkie S E Isaac P G Slater R J | 1993 | Theor Appl Genet1993，86，： | 1 |
| 17 | Accelerated rehabilitation after total knee replacement显示文摘 | Isaac D Falode T Liu P | 2005 | Knee2005，12，5： | 1 |
| 18 | Minimally invasive microendoscopy-assisted transforaminal lumbar interbody fusion with instrumentation 显示文摘 | Isaacs RE Podiehetty VK Santiago P | 2005 | J Neurosurg Spine2005，3，2： | 1 |
| 19 | Class Ⅲ beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel显示文摘 | Sève P Mackey J Isaac S | | 0，，12： | 1 |
| 20 | Class m beta-tubulin expression in tumor ceils predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel 显示文摘 | Seve P Mackey J Isaac S | 2005 | Mol Cancer Ther2005，4，12： | 1 |
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