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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 3 | An algorithm for the allocation of distribution system demand and energy loss显示文摘 | MACQUEEN C N IRVING M R | 1996 | IEEE Transactions on Power System1996，11，2： | 1 |
| 4 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 5 | Plug in to grid computing显示文摘 | M Irving G Taylor P Hobson | | 0，，： | 1 |
| 6 | The N - ray Affair显示文摘 | Klotz Irving M | 1980 | Scientific American1980，242，5： | 1 |
| 7 | Role of mitogen-and stress-acti- vated kinases in ischemic injury显示文摘 | Irving EA Bamford M | 2002 | J Cereb Blood Flow Metab2002，22，6： | 1 |
| 8 | Effect of valley switching and switching frequency limitation on line-current distortions of DCM/CCM boundary boost PFC converters 显示文摘 | HUBER L IRVING B T JOVANOVIC M M | 2009 | IEEE Trans on Power Electronics2009，24，2： | 1 |
| 9 | Seismic damage in reinforced concrete frames显示文摘 | BANON H IRVING H M BIGGS J M | 1981 | ASCE J Struct Eng1981，107，9： | 1 |
| 10 | NGX-4010,a eapsa- icin 8 dermal patch, administered alone or in combina- tion with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia 显示文摘 | Irving G Baekonja M Rauck R | 2012 | Clin J Pain2012，28，2： | 1 |
| 11 | Phylogeny of the serpin su- perfamily: implications of patterns of amino acid conservation for structure and function显示文摘 | Irving J A Pike R N Lesk A M | 2000 | Genome Res2000，10，12： | 1 |
| 12 | Eficacy and tolerability of gas? tric- retentive gabapentin for the treatment of postherpetic neural ? gia 显示文摘 | Irving G Jensen M Cramer M | 2009 | C lin J Pain2009，6，7： | 1 |
| 13 | Organic Food Trends in Australia显示文摘 | Irving M | | 0，，04： | 1 |
| 14 | For The Record: A Single Amino Acid Substitution Affects Substrate Specificity In Cysteine Proteinases From Fasciola Hepatica显示文摘 | Smooker P M Whisstock J C Irving J A | 2008 | Protein Sci2008，9，12： | 1 |
| 15 | Robust state estimator based on maximum constraints satisfaction of uncertain measurement显示文摘 | AL-OTHMAN A K IRVING M R | 2007 | Measurement2007，40，3： | 1 |
| 16 | Unenhanced CT for theevaluation of acute ureteric colic:the essential pictorial guide 显示文摘 | KENNISH S J WAH T M IRVING H C | 2010 | Postgraduate Medical Journal2010，86，1017： | 1 |
| 17 | Corrosion Pit Size Distribution and Fatigue Lives--a Study of the EIFS Technique for Fatigue Design in the Presence of Corrosion 显示文摘 | MEDVED J J BRETON M IRVING P E | 2006 | International Journal of Fatigue2006，26，1： | 1 |
| 18 | An algorithm for the allocation of distribution systemdemand and energy losses显示文摘 | Macqueen C N, Irving M R | 1996 | IEEE Transactions on Power Systems1996，11，1： | 1 |
| 19 | Small bowel fistula显示文摘 | Sansoni B Irving M | 1985 | World J Surg1985，9，6： | 1 |
| 20 | Combined active and reactive dispatch-Part 1: problem formulation and solution algorithm显示文摘 | Chebbo A M Irving M R | 1995 | IEE Proc Generation Transmission Distribution1995，142，4： | 1 |
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