| 1 | Age-related Changes in Familial Hypertrophic Cardiomyopathy Phenotype in Transgenic Mice and Humans显示文摘β-myosin heavy chain mutations are the most frequently identified basis for hypertrophic cardiomyopathy(HCM). A transgenic mouse model(αMHC403) has been extensively used to study various mechanistic aspects of HCM. There is general skepticism whether mouse and human disease features are similar. Herein we compare morphologic and functional characteristics, and disease evolution, in a transgenic mouse and a single family with a MHC mutation. Ten male αMHC403 transgenic mice(at –5 weeks, –12 weeks, and –24 weeks) and 10 HCM patients from the same family with a β–myosin heavy chain mutation were enrolled. Morphometric, conventional echocardiographic, tissue Doppler and strain analytic characteristics of transgenic mice and HCM patients were assessed. Ten male transgenic mice(αMHC403) were examined at ages –5 weeks, –12 weeks, and –24 weeks. In the transgenic mice, aging was associated with a significant increase in septal(0.59±0.06 vs. 0.64±0.05 vs. 0.69±0.11 mm, P<0.01) and anterior wall thickness(0.58±0.1 vs. 0.62±0.07 vs. 0.80±0.16 mm, P<0.001), which was coincident with a significant decrease in circumferential strain(–22%±4% vs. –20%±3% vs. –19%±3%, P=0.03), global longitudinal strain(–19%±3% vs. –17%±2% vs. –16%±3%, P=0.001) and E/A ratio(1.9±0.3 vs. 1.7±0.3 vs. 1.4±0.3, P=0.01). The HCM patients were classified into 1st generation(n=6; mean age 53±6 years), and 2nd generation(n=4; mean age 32±8 years). Septal thickness(2.2±0.9 vs. 1.4±0.1 cm, P<0.05), left atrial(LA) volume(62±16 vs. 41±5 mL, P=0.03), E/A ratio(0.77±0.21 vs. 1.1±0.1, P=0.01), E/e' ratio(25±10 vs. 12±2, P=0.03), global left ventricular(LV) strain(–14%±3% vs. –20%±3%, P=0.01) and global LV early diastolic strain rate(0.76±0.17 s-1 vs. 1.3±0.2 s-1, P=0.01) were significantly worse in the older generation. In β-myosin heavy chain mutations, transgenic mice and humans have similar progression in morphologic and functional abnormalities. The αMHC403 transgenic mouse model closely recapitulates human disease. | 罗鸿昌 Iraklis Pozios Styliani Vakrou Lars Sorensen Roselle M.Abraham Theodore Abraham | 2014 | Journal of Huazhong University of Science and Technology(Medical Sciences)2014，34，5： | 1 |
| 2 | Neuroticism personality trait is associated with Quality of Life in patients with Chronic Heart Failure显示文摘AIM: To evaluate Quality of life(QoL) in chronic heart failure(CHF) in relation to Neuroticism personality trait and CHF severity.METHODS: Thirty six consecutive, outpatients with Chronic Heart Failure(6 females and 30 males, mean age: 54 ± 12 years), with a left ventricular ejection fraction ≤ 45% at optimal medical treatment at the time of inclusion, were asked to answer the Kansas City Cardiomyopathy Questionnaire(KCCQ) for Quality ofLife assessment and the NEO Five-Factor Personality Inventory for personality assessment. All patients un-derwent a symptom limited cardiopulmonary exercise testing on a cycle-ergometer, in order to access CHF severity. A multivariate linear regression analysis us-ing simultaneous entry of predictors was performed to examine which of the CHF variables and of the person-ality variables were correlated independently to QoL scores in the two summary scales of the KCCQ, namely the Overall Summary Scale and the Clinical Summary Scale.RESULTS: The Neuroticism personality trait score had a significant inverse correlation with the Clinical Sum-mary Score and Overall Summary Score of the KCCQ(r =-0.621, P < 0.05 and r =-0.543, P < 0.001, respec-tively). KCCQ summary scales did not show significant correlations with the personality traits of Extraversion, Openness, Conscientiousness and Agreeableness. Mul-tivariate linear regression analysis using simultaneous entry of predictors was also conducted to determine the best linear combination of statistically significant univari-ate predictors such as Neuroticism, VE/VCO2 slope and VO2 peak, for predicting KCCQ Clinical Summary Score. The results show Neuroticism(β =-0.37, P < 0.05), VE/VCO2 slope(β =-0.31, P < 0.05) and VO2 peak(β = 0.37, P < 0.05) to be independent predictors of QoL. In multivariate regression analysis Neuroticism(b =-0.37, P < 0.05), the slope of ventilatory equivalent for carbon dioxide output during exercise,(VE/VCO2 slope)(b =-0.31, P < 0.05) and peak oxygen uptake(VO2 peak),(b = 0.37, P < 0.05) were independent predictors of QoL(adjusted R2 = 0.64; F = 18.89, P < 0.001).CONCLUSION: Neuroticism is independently associat-ed with QoL in CHF. QoL in CHF is not only determined by disease severity but also by the Neuroticism person-ality trait. | Lampros Samartzis Stavros Dimopoulos Christos Manetos Varvara Agapitou Athanasios Tasoulis Eleni Tseliou Iraklis Pozios Elisavet Kaldara John Terrovitis Serafim Nanas | 2014 | World Journal of Cardiology2014，6，10： | 1 |
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