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| 1 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 2 | 城市破碎绿化覆盖与热环境的关系——以德国波鸿市为例显示文摘在全球变暖和城市热岛(Urban Heat Island,UHI)现象加剧的趋势下,越来越多的城市居民将暴露于极端的高温天气中。城市绿地通过蒸腾作用和改变地表反射率降低了城市温度,提供了调节温度的生态系统服务功能。文章基于Landsat 5 TM卫星图像分析了德国波鸿市1989—2009年城市建设区域的破碎绿化覆盖率变化和地表温度(Land Surface Temperature,LST)变化,结果表明,在这20年间,波鸿市整体破碎绿化覆盖率有增加的趋势,并且缓解了城市热岛现象;通过地理加权回归(Geographically weighted regression,GWR)分析得知,绿化覆盖率与地表温度的变化具有显著的空间相关性;绿化覆盖率每上升10%,城市平均地表温度可降低0.98℃~1.29℃。借鉴波鸿城市发展经验,工业用地景观转型与提高破碎绿化覆盖率是有效缓解城市热岛现象的途径。 | 程安祺 Luis Inostroza | 2019 | 中国城市林业2019，17，6： | 4 |
| 3 | Secondary non-resectable liver tumors:A single-center living-donor and deceased-donor liver transplantation case series显示文摘Background: During the last decades, deceased-donor liver transplantation (DDLT) has gained a place in the therapeutic algorithm of well-selected patients harbouring non-resectable secondary liver tumors. Living-donor LT (LDLT) might represent a valuable means to further expand this indication for LT. Methods: Between 1985 and 2016, twenty-two adults were transplanted because of neuroendocrine ( n = 18, 82%) and colorectal metastases ( n = 4, 18%);50% received DDLT and 50% LDLT. In LDLT, 4 (36%) right and 7 (64%) left grafts were used;the median graft-to-recipient-weight ratios (GRWR) were 1.03%(IQR 0.86%- 1.30%) and 0.59%(IQR 0.51%- 0.91%), respectively. Median post-LT follow-up was 64 months (IQR 17–107) in the DDLT group and 40 months (IQR 35–116) in the LDLT group. DDLT and LDLT recipients were compared in terms of overall survival, graft survival, postoperative complications and recurrence. Results: The 1- and 5-year actuarial patient survivals were 82% and 55% after DDLT, 100% and 100% after LDLT, respectively ( P < 0.01). One- and 5-year actuarial graft survivals were 73% and 36% after DDLT, 91% and 91% after LDLT ( P < 0.01). The outcomes of right or left LDLT were comparable. Donor hepatectomy proved safe, and one donor experienced a Clavien IIIb complication. Bilirubin peak was significantly lower after left hepatectomy compared with that after right hepatectomy [1.3 (IQR 1.2–2.2) vs. 3.3 (IQR 2.3–5.2) mg/dL;P = 0.02]. Conclusions: The more recent LDLT series compared favorably to our DDLT series in the treatment of secondary liver malignancies. The absence of portal hypertension and the use of smaller left grafts make recipient and donor surgeries safe. The safety of the procedures and lack of interference with the scarce allograft pool are expected to lead to a more frequent use of LDLT in the field of transplant oncology. | Jan Lerut Samuele Iesari Gaetan Vandeplas Tiziana Fabbrizio Kevin Ackenine Milton Eduardo Inostroza Nunez Mina Komuta Laurent Coubeau Olga Ciccarelli Eliano Bonaccorsi-Riani | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 2 |
| 4 | Evaluating the Role of Ecosys- tem Services in Participatory Land Use Planning: Proposing a Bal- anced Score Card显示文摘 | Fuerst C Opdam P Inostroza L | 2014 | Landscape Ecol2014，，29： | 1 |
| 5 | Drying kinetics of Chrysanthe muscinerariae folium flowers and pyrethrin content decay during drying显示文摘 | Shene C Petit-Breuihl X Inostroza X | 1999 | Drying Technology1999，4，17： | 1 |
| 6 | The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function显示文摘 | TORCHIA J ROSE D W INOSTROZA J | 1997 | Nature1997，387，6634： | 1 |
| 7 | Specific impairment of 'what-where-when' episodic-like memory in experimental models of temporal lobe epilepsy显示文摘 | Inostroza M Brotons-Mas JR Laurent F | 2013 | J Neurosci2013，33，17： | 1 |
| 8 | Soluble Histocompatibility ClassⅠAntigens and Beta2 Microglobulin in Pregnant Females and Cord Blood Samples显示文摘 | Inostroza J Ferrada J Navarrete C | 1997 | Hum Immunol1997，54，1： | 1 |
| 9 | Visualization and comparison of architecture rationale with semantic web technologies显示文摘 | Lopez C Inostroza P Cysneiros L M | 2009 | Journal of Systems and Software2009，82，8： | 1 |
| 10 | A seismic vulnerability index for confined masonry shear wall buildings and a relationship with the damage 显示文摘 | Kenneth A Gent Franch Gian M Giuliano Morbelli Maximiliano A Astroza Inostroza | 2008 | Engineering Structures2008，30，10： | 1 |
| 11 | Cypermethrin effects on the adult mice seminal glands显示文摘 | Rodriguez H Tamayo C Inostroza J | 2009 | Ecotox Environ Safe2009，72，2： | 1 |
| 12 | The MAP kinases are differently utilized by CD28 and CD2 adhesion pathways in superantigen-activated Jurkat T cells 显示文摘 | Visse E Inostroza J Cabello G | 2003 | Biol Res2003，36，2： | 1 |
| 13 | Stearoyl CoA desaturase and fatty acid synthase gene polymorphisms and milk fatty acid composition in Chilean Black Friesian cows显示文摘 | Inostroza K B Scheuermann E S Sepúlveda N A | 2013 | Rev Colomb Cienc Pecu2013，26，： | 1 |
| 14 | Water use efficiency and associated physiological traits of nine naturalized white clover populations in Chile显示文摘 | Inostroza L Acuna H | 2010 | Plant Breeding2010，129，： | 1 |
| 15 | Trichodermaplant root colonization: Escaping early plant defense responses and activation of the antioxidant machinery for saline stress tolerance 显示文摘 | BROTMAN Y LANDAU U CUADROSINOSTROZA A | 2013 | PLoS Pathog2013，9，3： | 1 |
| 16 | The effect of the isopod parasite Ceratothoa gaudichaudii on the body weight of farmed Salmo salar in southern Chile显示文摘 | Sievers G Lobos C Inostroza R Ernst S | 1996 | Aquaculture1996，143，： | 1 |
| 17 | Visualization and comparison of architecture rationale with semantic web technologies显示文摘 | Claudia López Pablo Inostroza Luiz Marcio Cysneiros Hernán Astudillo | 2009 | The Journal of Systems & Software2009，，8： | 1 |
| 18 | Specific antibody deficiency with normal immunoglobulin concentration in children with reeurrent respiratory infections显示文摘 | Quezada A Norambuena X Inostroza J | 2015 | Allergol Immunopathol2015，43，3： | 1 |
| 19 | The MAP kinases are differently utilized by CD28 and CD2 adhesion pathways in superantigenacti- vated Jurkat T cells 显示文摘 | Visse E Inostroza J Cabello G | 2003 | Biol Res2003，36，2： | 1 |
| 20 | Cyper-methrin effects on the adult mice seminal glands显示文摘 | RODRIGUEZA H TAMAYOA C INOSTROZA J | 2009 | Ecotoxicolo-gy and Environmental Safety2009，72，2： | 1 |
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