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| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | APC Yin -Yang haplotype associated with colorectal cancer risk 显示文摘 | Garre P DE LA Hoya M Iniesta P | 2010 | Exp Ther Med2010，1，5： | 1 |
| 3 | Clinical relevance of MMP-9,MMP-2,T1MP-1 and TIMP-2 in colorectal cancer显示文摘 | Moran A Iniesta P Garcia-Aranda C | 2005 | Oncol Rep2005，13，1： | 1 |
| 4 | Electrodeposition of PbO2 on glassy carbon electrodes: Influence of ultrasound power显示文摘 | Gonzalez Garcia J Saez V Iniesta J | 2002 | Electrochemistry Communications2002，4，5： | 1 |
| 5 | Role of fibrinogen levels and factor V34L polymorphism in thrombolytic therapy in stroke patients显示文摘 | González-Conejero R Fernández-Cadenas I Iniesta JA | 2006 | Stroke2006，37，9： | 1 |
| 6 | Platelet GP IIIa polymorphism HPA-1 (P1A) protects against subarachnoid hemorrhage显示文摘 | Iniesta J A Gonzlez-Conejero R G Piqueras C | 2004 | Stroke2004，35，10： | 1 |
| 7 | Mesen-chymal dental stem cells in regenerative dentistry显示文摘 | Rodriguez-Lozano FJ Insausti CL Iniesta F | 2012 | MedOral Patol Oral Cir Bucal2012，17，6： | 1 |
| 8 | Role of fibrinogen levels and factor XⅢ V34L polymorphism in throm-bolytic therapy in stroke patients显示文摘 | Gonzalez-Conejero R Fernandez-Cadenas I Iniesta JA | 2006 | Stroke2006，37，： | 1 |
| 9 | 显示文摘 | INIESTA J MICHAUD P A PANIZZA M | 2001 | Electrochemistry Communication2001，，3： | 1 |
| 10 | Electrochemical oxidation of phenol at boron-doped diamond electrode 显示文摘 | Iniesta J Michaud P A Panizza M | 2001 | Electrochimica Acta2001，46，23： | 1 |
| 11 | Use of hydrogen diffusion anodes during lead electro - winning in a chloride medium 显示文摘 | Exposito E Iniesta J Gonzalez- Garcia J | 2001 | Journal of Power Sources2001，101，1： | 1 |
| 12 | The effects of regulated and continuous deficit irrigation on the water use, growth and yield of olive trees显示文摘 | Iniesta F Testi L Orgaz F | 2009 | European Journal of Agronomy2009，30，4： | 1 |
| 13 | Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non- small cell lung cancer显示文摘 | Iniesta P Moran A De Juan C | 2007 | Oncol Rep2007，17，1： | 1 |
| 14 | Salinas, crop water stress index is a sensitive water stress indictor in pistachio tress显示文摘 | Testi L Goldhamer D A Iniesta F | 2008 | Irrigation Science2008，26，5： | 1 |
| 15 | Cooperative role of telomerase activity and p16 expression in the prognosis of non-small-cell lung cancer 显示文摘 | Gonzalez-Quevedo R Iniesta P Moran A | 2002 | J Clin Oncol2002，20，1： | 1 |
| 16 | Electro-chemical treatment of industrial wastewater containing phe-nols显示文摘 | Iniesta J Exposito E Gonzalez-Garc1a J | | 0，，05： | 1 |
| 17 | Electrochemical Oxidation of Phenol at Boron-doped Diamond Electrode显示文摘 | INIESTA J MICHAUD P A CERISOLA G | 2001 | Electrochemical Acta2001，46，23： | 1 |
| 18 | Influence of chloride ion on electrochemical degradation of phenol in al-kalinemediumusing bismuth doped and pure PbO2anodes显示文摘 | Iniesta J Gonzalez-Garc1a J Exposito E | | 0，，14： | 1 |
| 19 | Clinical relevance of MMP-9,MMP-2,TIMP-2 in colorectal cancer显示文摘 | Moran A Iniesta P Garcia-Aranda C | 2005 | Oncol Rep2005，13，1： | 1 |
| 20 | Cooperative role of telomerase activity and p16 expression in the prognosis of non - small - cell lung cancer 显示文摘 | González - Quevedo R Iniesta P Morán A | 2002 | J Clin Oncol2002，20，1： | 1 |
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