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		题名	作者	年代	出处	被引量
	1	Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials.	Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani	2018	World Journal of Radiology2018，10，10：	3
	2	Isocratic simultaneous revesed-phase high performance liquid chromatographic estimation of six drugs for combined hypertension therapy 显示文摘	YAGNESH P P SUVARNA P INDRAVADAN C B	1998	J Chromatogr A1998，828，12：	1
	3	Packed column supercritical fluid chromatographic separation and estimation of acetaminophen, diclofenac sodium and meth- oearbamol in pharmaceutical dosage forms 显示文摘	Suvarna T P Sundaresan M Indravadan C	1998	Talanta1998，47，1：	1
	4	Consensus Guidelines for Periprocedural Management of Coagulation Status and Hemostasis Risk in Percutaneous Image-guided Interventions显示文摘	Indravadan J. Patel Jon C. Davidson Boris Nikolic Gloria M. Salazar Marc S. Schwartzberg T. Gregory Walker Wael A. Saad	2012	Journal of Vascular and Interventional Radiology2012，，：	1
	5	Behavior of bond under dynamic loading显示文摘	Shah indravadan K	1962	ACI Journal Proceedings1962，19，4：	1
	6	The effect of selected direct compression excipients on the stability of aspirin as a model hydrolyzable drug显示文摘	Nagin K Indravadan J Anthony J	1988	Drug Dev Ind Pharm1988，14，1：	1

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