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| 1 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 2 | Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients显示文摘AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA. | Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo Hoshino Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 4 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 5 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 6 | Greenhouse gas emissions from a constructed wetland for municipal sewage treatment显示文摘The fluxes of greenhouse gases (methane and nitrous oxide) emission from a constructed wetland in the Eastern China as municipal sewage treatment were measured from June 1999 to August 2000 by the closed chamber method. The constructed wetland for municipal sewage treatment is a significant source of methane, up to 976 6×10 6 g CH 4/a, which was emitted from the constructed wetland with the area of 495000 m 2 and wastewater loading rate of 12000 m 3/d. Its daily mean methane flux reached 5 22 g CH 4/(m 2·d), 250 times as much as that in natural wetland in the same latitude region. 227 8 mg CH 4 was produced from the treatment of 1 liter wastewater, up to 700—1000 times as much as that in the secondary treatment. The emission of nitrous oxide from the constructed wetland is not higher than that from secondary treatment of wastewater, only 0 07 mgN 2O/L. | TAI Pei dong 1, LI Pei jun 1 , SUN Tie heng 1, HE Yao wu 1, ZHOU Qi xing 1 GONG Zong qiang 1, Motoyuki Mizuochi 2, Yuhei Inamori 2 (1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110015, China. 2 National Insti | 2002 | Journal of Environmental Sciences2002，14，1： | 3 |
| 7 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 8 | Pilot-scale studies of domestic wastewater treatment by typical constructed wetlands and their greenhouse gas emissions显示文摘Three typical constructed wetlands(CWs)including Vertical Flow(VF),Free Water Surface(FWS),and Subsurface Flow(SF),and combined VF-SF-FWS constructed wetlands were investigated for the treatment of domestic wastewater with low C/N ratio.The performance of nutrient removal and the characteristics of greenhouse gas emissions,such as CH4 and N2O,from these CWs were compared.The results indicated that the four types of CWs had high removal efficiencies for organic matter and suspended solid(SS).The combined wetland also showed a comparatively good performance for nitrogen and phosphorus removal,and the removal efficiencies for total nitrogen(TN)and total phosphorus(TP)were 81.3%and 84.5%,respectively.The combined CWs had a comparative lower global warming potential.The FWS CW had the highest tendency to emit CH4 and led to a higher global warming potential among the four types of CWs,which was about 586 mg CO_(2)/m^(2)·h. | Chaoxiang LIU Kaiqin XU Ryuhei INAMORI Yoshitaka EBIE Jie LIAO Yuhei INAMORI | 2009 | Frontiers of Environmental Science & Engineering2009，3，4： | 2 |
| 9 | Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study显示文摘 | Kensuke Kubota Yukio Kakuta Shunji Kawamura Yasunobu Abe Masahiko Inamori Harunobu Kawamura Hiroyuki Kirikoshi Noritoshi Kobayashi Satoru Saito Atushi Nakajima | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，5： | 2 |
| 10 | Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer显示文摘 | K. Okada J. Fujisaki T. Yoshida H. Ishikawa T. Suganuma A. Kasuga M. Omae M. Kubota A. Ishiyama T. Hirasawa A. Chino M. Inamori Y. Yamamoto N. Yamamoto T. Tsuchida Y. Tamegai A. Nakajima E. Hoshino M. Igarashi | 2012 | Endoscopy2012，，02： | 2 |
| 11 | Effect of hydraulic retention time on the hydrogen yield and population of Clostridium in hydrogen fermentation of glucose显示文摘The conversion of glucose to hydrogen was evaluated using continuous stirred tank reactor at pH 5.5 with various hydraulic retention times (HRT) at 30°C. Furthermore, the population dynamics of hydrogen-producing bacteria was surveyed by fluorescence in-situ hybridization using probe Clost IV targeting the genus Clostridium based on 16S rRNA. It was clear that positive correlation was observed between the cells quantified with probe Clost IV and hydrogen yield of the respective sludge. The numbers of hydrogen- producing bacteria were decreased gradually with increasing HRT, were 9.2 × 108, 8.2 × 108, 2.8 × 108, and 6.2 × 107 cell/mL at HRT 6, 8, 12, and 14 h, respectively. The hydrogen yield was 1.4-1.5 mol H2/mol glucose at the optimum HRT range 6-8 h. It is considered that the percentage of the hydrogen-producing bacteria to total bacteria is useful parameter for evaluation of hydrogen production process. | CHU Chunfeng EBIE Yoshitaka INAMORI Yuhei KONG Hainan | 2009 | Journal of Environmental Sciences2009，21，4： | 2 |
| 12 | Investigating CH 4 and N 2 O emissions from eco-engineering wastewater treatment processes using constructed wetland microcosms显示文摘 | R. Inamori P. Gui P. Dass M. Matsumura K.-Q. Xu T. Kondo Y. Ebie Y. Inamori | 2006 | Process Biochemistry2006，，3： | 2 |
| 13 | Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification显示文摘 | Inamori M Togawa JI Nagase H | 2003 | J Gastroencterol Hepatol2003，18，： | 1 |
| 14 | Distribution characteristics of ammonia-oxidizing bacteria in the Typha latifolia constructed wetlands using fluorescent in situ hybridization(FISH)显示文摘A molecular biology method, fluorescent in situ hybridization(FISH), in which the pre-treatment was improved in allusion to the media of the constructed wetlands(CW), e.g. the soil and the grit, was used to investigate the vertical distribution characteristics of ammonia-oxidizing bacteria(AOB) quantity and the relation with oxidation-reduction potential(ORP) in the Typha latifolia constructed wetlands under three different loadings in summer from May to September. Results showed that the quantity of the AOB decreased in the Typha latifolia CW with the increase of vertical depth. However, the AOB quantity was 2—4 times the quantity of the control in the root area. Additionally, ORP in the rhizosphere was found to be higher than other areas, which showed that Typha latifolia CW was in an aerobic state in summer when using simulated non-point sewage at the rural area of Taihu Lake in China and small town combined sewage. | YAN Li Ryuhei Inamori GUI Ping XU Kai-qin KONG Hai-nan Masatoshi Matsurnura Yuhei Inamori | 2005 | Journal of Environmental Sciences2005，17，6： | 1 |
| 15 | Measurements of N2O and CH4 from the aerated composting of food waste显示文摘 | He Y W Inamori Y Mizuochi M | 2000 | Science of the Total Environment2000，254，1： | 1 |
| 16 | Biodegradation and adsorption in refractory leachate treatment by the biological activated carbon fluidized-bed process 显示文摘 | Imai A Onuma K Inamori Y | 1995 | Water Research1995，29，2： | 1 |
| 17 | Predation and degradation characteristics of microcystis forming water bloom by combination of functional micro-animals显示文摘 | IWAMI N INAMORI Y | 1999 | Japanese Journal Water Treatment Biology1999，35，4： | 1 |
| 18 | Reliable data transmission for resonant-type wireless power transfer显示文摘 | Noguchi S Inamori M Sanada Y | 2013 | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences2013，96，1： | 1 |
| 19 | Insufflation of Hydrogen Gas Restrains the InfIamrnatory Response o{ Cardiopulmonary Bypass in a Rat Model显示文摘 | Fujii Y Shirai M InamoriS | 2013 | Artif Organs2013，37，2： | 1 |
| 20 | Greenhouse effect gas control producing from waste water treatment process 显示文摘 | Inamori Y Hasomi M Sudo R | 1991 | Water Waste1991，33，2： | 1 |
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