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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Acute Mountain Sickness: Pathophysiology, Prevention, and Treatment显示文摘 | Chris Imray Alex Wright Andrew Subudhi Robert Roach | 2010 | Progress in Cardiovascular Diseases2010，，6： | 2 |
| 3 | Acute mountain sickness: pathophysiology, prevention, and treatment 显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
| 4 | Acute mountain sickness: Pathophysiology, prevention, and treatment显示文摘 | Chris Imray A W Andrew Subudhi Robert Roach | 2010 | Progress in Cardiovascular Diseases2010，52，6： | 1 |
| 5 | Effects of dietary n-3 and saturated fats on growth rates of the human colonic cancer cell lines SW2620 and IS 174T in vivo in relation to tissue and plasma lipids 显示文摘 | Sakaguchi M Imray C Davis A | 1990 | Anticancer Res1990，10，6： | 1 |
| 6 | Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method显示文摘 | NG J C JOHNSON D IMRAY P | 1998 | Analyst1998，123，5： | 1 |
| 7 | Acute mountain sickness : pathophysiology, prevention, and treatment 显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovase Dis2010，52，： | 1 |
| 8 | Complex interaction between tori and onset of three-fre- quency quasi-perlodicity in a current mode controlled Boost converter 显示文摘 | GIAOURIS D BANERJEE S IMRAYED O | 2012 | IEEE Transaction on Circuits and Systems I : Regular Papers2012，59，1： | 1 |
| 9 | Renal artefiovenous fistula associated with fibromuscular dysplasia显示文摘 | Imray TJ Cohen A J Hahn L | | 0，，： | 1 |
| 10 | Arachidonic acid and docosahexaenoic acid are increased in human colorectal cancer显示文摘 | Neoptolemos J P Husband D Imray C | 1991 | Gut1991，32，3： | 1 |
| 11 | Acute mountain sickness: pathophysiology, prevention, and treatment 显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
| 12 | Complex interaction between tori and onset of three-frequency quasi-periodicity in a current mode controlled Boost converter显示文摘 | GIAOURIS D BANERJEE S IMRAYED 0 et a1 | 2012 | IEEE Transactions on Circuits and Systems I: Regular Papers2012，59，1： | 1 |
| 13 | Complexinteraction between tori and onset of three-frequency quasi-periodicity in current mode controlled Boost converter显示文摘 | GIAOURIS D BANERJEE S IMRAYED 〇 | 2012 | IEEETrans on Circuits and Systems2012，59，1： | 1 |
| 14 | The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: a randomized trial显示文摘 | Markus HS McCollum C Imray C | 2011 | Stroke2011，42，： | 1 |
| 15 | Acute mountain sickness: pathophysiology, prevention, and treatment 显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
| 16 | Acute Mountain Sickness: Patho-physiology, Prevention, and Treatment显示文摘 | Imray C Wright A Subudhi A | 2010 | Progress in Cardiovascular Diseases2010，，52： | 1 |
| 17 | Acute altitude illnesses 显示文摘 | Imray C Booth A Wright A | 2011 | BMJ2011，343，： | 1 |
| 18 | Acute mountain sickness: pathophysiology, prevention, and treatment显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
| 19 | Acute mountain sickness: Pathophysiology,prevention,and treatment显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
| 20 | Acute mountain sickness: pathophysiology, prevention, and treatment显示文摘 | Imray C Wright A Subudhi A | 2010 | Prog Cardiovasc Dis2010，52，6： | 1 |
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