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1篇 您的检索式：作者名="Ikewuchi Jude C"

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		题名	作者	年代	出处	被引量
	1	Moderation of hematological and plasma biochemical indices of subchronic salt-loaded rats,by an aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg(Euphorbiaceae)显示文摘Objective:To investigate the effects of an aqueous leaf extract of Acalypha wilkesiana (A.wilkesiana) on plasma chemistry and hematological indices of sub-chronic salt-loaded rate. Method:The control group received a diet consisting 100%of the commercial feed,while the four test groups were received a diet consisting 8%salt and 92%commercial feed all through, except for the reference treatment group that had its salt-loading discontinued after six weeks. The extract was orally administered daily at 200 and 250 mg/kg body weight;while the test control,reference and control groups received appropriate volumes of water by the same route. Results:The extract had no negative effects on markers of liver and kidney functions,produced hemoconcentration,significantly higher(P<0.05) plasma calcium and potassium levels,and significantly lower(P<0.05) plasma sodium and chloride levels in the test animals compared to test control.Conclusions:This result supports the traditional use of A.wilkesiana in the management of hypertension and suggesls that the extract may be a potassium sparing diuretic whose mechanism of antihypertensive action may be via alteration of plasma sodium and potassium balances or calcium mediated alteration in vascular muscle tone.	Ikewuchi Jude C	2013	Asian Pacific Journal of Tropical Medicine2013，6，1：	1

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