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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Structural dynamics with parameter uncertainties显示文摘 | Ibrahim R | 1987 | Applied Mechanics Reviews1987，40，3： | 4 |
| 4 | Modelling of Electromagnetically Excited Turbulent Flow of Molten Metal in a TwinChannel Induction Furnace显示文摘 | Ghojel J Ibrahim R N | 2006 | Progress in Computational Fluid Dynamics2006，，7： | 1 |
| 5 | The experimental determination of vibration parameters from time responses 显示文摘 | IBRAHIM S R MIKULCIK E C | 1976 | Shock and Vibration Bulletin1976，46，5： | 1 |
| 6 | Preservation of raw milk by activation of the natural lactoperoxidase systems显示文摘 | HADDADIN M S IBRAHIM S A ROBINSON R K | 1996 | Food Control1996，7，3： | 1 |
| 7 | Immunosuppmssive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L 显示文摘 | Pereira R L Ibrahim T Lucchetti L | 1999 | Immunopharmacology1999，43，1： | 1 |
| 8 | Friction -induced vibration, chatter, squeal, and chaos, Part 2 : Dynamics and modeling显示文摘 | Ibrahim R A | 1994 | Applied Mechanics Review1994，47，： | 1 |
| 9 | A cDNA encoding farnesyl pyrophosphate synthase in white lupin 显示文摘 | Attucci S Aitken S M Ibrahim R K | 1995 | Plant Physiol1995，108，： | 1 |
| 10 | Recent advances in liquid sloshing dynamics 显示文摘 | Ibrahim R A Pilipchuk V N | 2001 | Applied Mechanics Review2001，54，2： | 1 |
| 11 | Multivari- ate statistical model for 3D image segmentation with application to medical images显示文摘 | John N M Kabuka M R Ibrahim M O | 2003 | Journal of Digital Imaging2003，16，4： | 1 |
| 12 | A multi -criteria approach to contractor selection 显示文摘 | IBRAHIM M M MIKE J R SAMI M F | 2002 | Engi- neering Construction and Architectural Management2002，9，1： | 1 |
| 13 | The effects of obstructions on overpressure resulting from premixed flame deflagration显示文摘 | Ibrahim S S Masri A R | 2001 | Journal of Loss Prevention in the Process Industries2001，14，3： | 1 |
| 14 | A Parametric study of the Ibrahim Time Doamin Modal Identification Algorithm 显示文摘 | Pappa R S Ibrahim S R | 1980 | Shock & Vibration Bulletin1980，51，3： | 1 |
| 15 | A method for the direct identification of vibration parameters from the free response 显示文摘 | IBRAHIM S R MIKULCIK E C | 1977 | Shock and Vibration Bulletin1977，47，4： | 1 |
| 16 | Combination polyene- caspofungin treatment of rhino -orbital-cerebral mucormycosis 显示文摘 | Reed C Bryant R Ibrahim AS | 2008 | Clin Infect Dis2008，47，： | 1 |
| 17 | Differentiation of Species and populations of Aphelenchoides and of Ditylenchus angustus using a fragment of ribosomal DNA显示文摘 | Ibrahim S K Perry R N Burrows P R at al | 1994 | Journal of Nematology1994，26，4： | 1 |
| 18 | Nonlinear Friction-induced Vibration in Water-lubricated Bearings显示文摘 | Simpson T A Ibrahim R A | 1996 | Journal of Vibration and Control1996，4，1： | 1 |
| 19 | Enhanced secretion of hydrophobic peptide fused lysozyme by the introduction of N-glycosylation signal and the disruption of calnexin gene in Saccharomyces cerevisiae 显示文摘 | Arima H Kinoshita T Ibrahim H R | 1998 | FEBS Letters1998，440，12： | 1 |
| 20 | Experimental study of premixed flame propagation over various solid obstructions显示文摘 | Masri A R Ibrahim S S Nehzat N | 2000 | Experimental Thermal and Fluid Science2000，21，13： | 1 |
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