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| 1 | Small bowel capsule endoscopy in patients with cardiac pacemakers and implantable cardioverter defibrillators:Outcome analysis using telemetry review显示文摘AIM:To determine if there were any interactions between cardiac devices and small bowel capsules secondary to electromagnetic interference (EMI) in patients who have undergone small bowel capsule endoscopy (SBCE).METHODS:Authors conducted a chart review of 20 patients with a cardiac pacemaker (CP) or implantable cardioverter defibrillator (ICD) who underwent continuous electrocardiographic monitoring during their SBCE from 2003-2008.authors searched for unexplained electrocardiogram (ECG) findings,changes in CP andICD set parameters,any abnormality in transmitted capsule data,and adverse clinical events.RESULTS:There were no adverse events or hemodynamically significant arrhythmias reported.CP and ICD set parameters were preserved.The majority of ECG abnormalities were also found in pre-or post-SBCE ECG tracings and the CP behavior during arrhythmias appeared appropriate.Two patients seemed to have episodes of undersensing by the CP.However,similar findings were documented in ECGs taken outside the time frame of the SBCE.One patient was observed to have a low signal encountered from the capsule resulting in lack of localization,but no images were lost.CONCLUSION:Capsule-induced EMI remains a possibility but is unlikely to be clinically important.CPinduced interference of SBCE is also possible,but is infrequent and does not result in loss of images transmitted by the capsule. | Justin R Cuschieri Mohammed N Osman Richard CK Wong Amitabh Chak Gerard A Isenberg | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 6 |
| 2 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 3 | Asthma and emotion:a review显示文摘 | Lehrer PM Isenbergs A Hochron SM | 1993 | Asthma1993，30，： | 2 |
| 4 | The effect of interleukin-10 and of interleukin-12 on the in vitro production of anti-double-stranded DNA antibodies from patients with systemic lupus erythematosus 显示文摘 | Tyrrell-Price J Lydyard P M Isenberg D A | 2001 | Clin Exp Immunol2001，124，1： | 2 |
| 5 | The Einstein-Scalar Field Constraints on Asymptotically Euclidean Manifolds显示文摘由使用保角的方法,爱因斯坦数量的解决方案回答重力的限制方程被获得。因为分级的领域介绍三个额外的术语进 Lichnerowicz 方程,而非就方程,处理分级的领域比处理象液体,麦克斯韦领域或 Yang 工厂领域那样的事领域是更多的质问。证明是建设性的并且允许任意的尺寸(>
2 ) 象低整齐一样起始的数据。 | Yvonne CHOQUET-BRUHAT James ISENBERG Daniel POLLACK | 2006 | Chinese Annals of Mathematics,Series B2006，27，1： | 2 |
| 6 | SLICC/ ACR damage index is valid and renal and pulmonary organ scores are predictors of severe outcome in patients with systemic lupus erythematosus显示文摘 | Seifert B Isenberg DA | 1996 | Br J Rheumatol1996，35，2： | 1 |
| 7 | Small-diameter artificial arteries engineered in vitro显示文摘 | Isenberg BC Williams C Tranquillo RT | 2006 | Circ Res2006，98，1： | 1 |
| 8 | Finite element for rock joints and interfaces 显示文摘 | Ghaboussi J Wilson E L Isenberg J | 1973 | Journal of Soil Mechanics and Foundations ASCE1973，99，10： | 1 |
| 9 | A review of gastrointestinal manifestations of systemic lupus erythematosus显示文摘 | Sultan SM Ioannou Y Isenberg DA | 1999 | J Rheumatol1999，38，： | 1 |
| 10 | Outcomes and complications of elastic stable intramedullary nailing for forearm fractures in children显示文摘 | Jubel A Andermahr J Isenberg J | 2005 | Journal of Pediatric Orthopaedics B2005，14，5： | 1 |
| 11 | Analy- sis of variable region genes encoding anti-Sm and anti-cardi- olipin antibodyfrom a systemic lupus erythematosus patients显示文摘 | DEMAISON C RAVLRAJAN CT ISENBERG DA | 1995 | Immunology1995，86，3： | 1 |
| 12 | Influence of race/ ethnicity onresponse to lupus nephritis treatment:the ALMS study显示文摘 | Isenberg D Appel GB Contreras G etal | 2010 | Rheumatology2010，49，1： | 1 |
| 13 | The chemical biology of nitric oxide: implications in cellular signaling显示文摘 | Thomas DD Ridnour LA Isenberg JS | 2008 | Free Radic Biol Med2008，45，1： | 1 |
| 14 | Use of anticitrullianted peptide and-PA33 antibodies in distinguish erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis显示文摘 | Mediwake R Isenberg DA Scbellekens GA | 2001 | Ann Rheum Dis2001，60，1： | 1 |
| 15 | Treatment of polymyositis and dermaomyositis显示文摘 | Kaye S A Isenberg D A | 1994 | Br Hos J Med1994，52，9： | 1 |
| 16 | Comparison of renal disease severity and outcome in patients with primary antiphospholipid syndrome, antiphospholipid syndrome secondary to systemic lupus erythematosus (SLE) and SLE alone显示文摘 | Moss KE Isenberg DA | 2001 | Rheumatology (Oxford)2001，40，8： | 1 |
| 17 | Drug-induced lupus: Including anti-tumour necrosis factor and interferon induced 显示文摘 | Araujo-Femendez S Ahijon-Lana M Isenberg DA | 2014 | Lupus2014，23，6： | 1 |
| 18 | Early treatment with rituximab in newly diagnosed systemic lupus erythematosus patients: a steroid-sparing regimen显示文摘 | Ezeonyeji A N Isenberg D A | 2012 | Rheumatology (Oxford)2012，51，3： | 1 |
| 19 | Does prophylactic pancreatic stent placement reduce the risk Of post-ERCP acute pancreatitis? A meta-analysis Of controlled trials 显示文摘 | SinghP Das A Isenberg G | 2004 | Gastrointest Endosc2004，60，4： | 1 |
| 20 | New therapies for rheumatoid arthritis显示文摘 | Goldblatt F Isenberg DA | 2005 | Clin Exp Immunol2005，140，2： | 1 |
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