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| 1 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | Expression and function of ATP dependent potassium channels in late post infarction remodeling 显示文摘 | Nadia I Pierre P Irene P | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 4 | Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients显示文摘 | Giovanni S Teresa P Irene C | 2006 | Cancer2006，106，： | 1 |
| 5 | 16S rRNA and 16S to 23S internal transcribed spacer sequence analysisreveal inter and intraspecific Bifidobacteriumphylogeny显示文摘 | Nathalie L B Herve P Irene M | 1996 | lntem J Syst Bacteriology1996，46，： | 1 |
| 6 | Atrazine interactions with soil Humic substances of different molecular structure显示文摘 | Alessandro P Pellegrino C Irene S | 1998 | J Environ Qual1998，27，： | 1 |
| 7 | Imagining Stereotypes Away: The Moderation of Implicit Stereotypes Through Mental Imagery 显示文摘 | Irene V Blair Jennifer E Ma Alison P Lenton | 2001 | Journal of Personality and Social Psychology2001，，81： | 1 |
| 8 | Trace of Flicker Sources by Using the Quantity of Flicker Power显示文摘 | Axelberg P G V Bollen M H J Gu Irene Yu-Hua | 2008 | IEEE Trans on Power Delivery2008，23，1： | 1 |
| 9 | Re - engineering the toilet for sustainable wastewater management 显示文摘 | Tove AL Irene P Alfredo A | 2001 | ES&T2001，35，9： | 1 |
| 10 | 16S rRNA and 16S to 23S internal transcribed spacer sequence analyses reveal inter and intraspecific bifidobacterium phylogeny显示文摘 | LEBLOND-BOURGET N HERVE P IRENE M | 1996 | Int J Syst Bacteriol1996，46，： | 1 |
| 11 | Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease显示文摘 | Irene C Teresa P | 1999 | Eng J Med1999，1，34： | 1 |
| 12 | Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant显示文摘 | Gao P Mariya M Irene X | | 0，，： | 1 |
| 13 | 16S rRNA and 16S to 23 S internal transcribed spacer sequence analysis reveal inter and intraspecific Bifidobacterium phylogeny显示文摘 | Nathalie L B Helve P Irene M | 1996 | Intern J Syst Bacteriology1996，46，： | 1 |
| 14 | Characteristic and performance of 500 F asymmetric cybrid advanced supercapaeitor protoypes 显示文摘 | Aurelien P Irene P Gural J | 2003 | Power Sources2003，113，： | 1 |
| 15 | 16S rRNA to 23S internal transcribed spacer sequence analyses reveal inter - and intraspecific Bifidobacterium phylogeny 显示文摘 | Nathalie L B Herve P Irene M | 1996 | International Journal of Systematic and Evolutionary Microbiology1996，46，1： | 1 |
| 16 | The occur- rence and identification of C30, C31 and C3z alkan-1, 15-diols and alkan-15-one-l-ols in Unit I and Unit II Black Sea sedi- ments 显示文摘 | de Leeuw J W Irene W Rijpstra C Schenck P A | 1981 | Geochim Cosmochim Acta1981，45，11： | 1 |
| 17 | Influences of humic acid, bicarbonate and calcium on Cr(VI) reductive removal by zero- valent iron显示文摘 | LIU T Z RAO P H 1o IRENE M C | 2009 | Sci Total Environ2009，407，： | 1 |
| 18 | 16S rRNA and 16S to 23S internal transcribed spacer sequence analysis reveal inter and inlraspeeific Bifidobaeterium phylogeny 显示文摘 | Nathalie L B Herve P Irene M | 1996 | Int J Sys Baeteriol1996，46，1： | 1 |
| 19 | Impacts of clinatic change and fishing on pacifc salm on abundance over the past 300 years显示文摘 | Bruce P F Irene G E Jon S | 2009 | Science2009，290，5492： | 1 |
| 20 | Valve Repair for Bicuspid Aortic Valve Regurgitation:An Option显示文摘 | Irene M Belen P Pastora G | 2007 | Rev Esp Cardiol2007，60，2： | 1 |
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