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| 1 | Functional implications of axon initial segment cytoskeletal disruption in stroke显示文摘轴突起始的片断(AIS ) 是轴突的近似部分,它不被髓磷脂鞘盖住并且拥有电压门离子隧道的一个特殊、专业化集会并且联系蛋白质。AIS 在中央神经原在 synaptic 集成和行动潜力产生起关键作用。最近的证据证明那击引起包围 ischemic 的神经原的 AIS 细胞骨架的快速的、不可逆的调停 calpain 的解朊作用坏死的核心。位于这 “ 下面的分子的机制的更好的理解; non-lethal”neuronal 损坏可能为改进击结果提供新治疗学的策略。这里,我们在场结构的简短概述和 AIS 的功能。我们然后讨论位于导致击的 AIS 损坏下面的可能的机制,包括 calpains 的角色和 Ca 2+ 离子的可能的来源,它为 calpains 的激活是必要的。最后,我们为 neuronal 易兴奋性讨论 AIS 细胞骨架和离子隧道簇的损失的潜在的功能的含意。 | Ohad STOLER Ilya A FLEIDERVISH | 2016 | Acta Pharmacologica Sinica2016，37，1： | 5 |
| 2 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 3 | Rituximab in neuromyelitis optica: A review of literature显示文摘Neuromyelitis optica spectrum disorders, or neuromyelitis optica(NMO), is an autoimmune disease of the central nervous system that must be distinguished from multiple sclerosis. Therapeutic approaches to relapse prevention in NMO include immunosuppressants and monoclonal antibodies. Rituximab, a monoclonal antibody that targets CD20 antigen expressed on the surface of pre-B, mature B-lymphocytes and a small subset of T-lymphocytes, has been widely used for the treatment of NMO. In this review, we aim to summarize global experience with rituximab in NMO. We identified 13 observational studies that involved a total of 209 NMO patients treated with rituximab. Majority of rituximab-treated patients evidenced stabilization or improvements in their disability scores compared to pre-treatment period and 66% of patients remained relapse-free during treatment period. Monitoring rituximab treatment response with CD19+ or CD27+ cell counts appears to improve treatment outcomes. We offer clinical pointers on rituximab use for NMO based on the literature and authors' experience, and pose questions that would need to be addressed in future studies. | Ericka Wong Vijay A Vishwanath Ilya Kister | 2015 | World Journal of Neurology2015，5，1： | 2 |
| 4 | Bioleaching of metals from electronic scrap by moderately thermophilic aeidophilic bacteria 显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hydrometallurgy2007，88，14： | 1 |
| 5 | A note on the removal of phytate in soybean meal using Aspergillus usami显示文摘 | ILYAS A M HIRABAYASHI T MATSUI H | 1995 | Asian-Australasian Journal of Animal Sciences1995，8，2： | 1 |
| 6 | High Performance Top Emitting OLED Devices显示文摘 | All T A Ilyas I Khayrullin el al | 2007 | SID2007，59，： | 1 |
| 7 | Modeling and querying possible repairs in duplicate detection 显示文摘 | Beskales G Soliman M A Ilyas I F | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 8 | A comparison of early clinical and radiographic complications of iliac screw fixation versus s2 alar iliac ( S2AI ) fixation in the adult and pediatric populations 显示文摘 | Ilyas H Place H Puryear A | 2015 | J Spinal Disord Tech2015，28，4： | 1 |
| 9 | 查看详情显示文摘 | Becer C R Gibson M I Geng J Ilyas R Wallis R Mitchell D A Haddleton D M | | 0，，43： | 1 |
| 10 | Efficient search for the top-k probable nearest neighbors in uncertain databases 显示文摘 | Bekales G Soliman M A Ilyas I F | 2008 | Proc of the VLDB Endowment2008，1，1： | 1 |
| 11 | Expression and activity of paraoxonase 1 in human cataractous lens tissue 显示文摘 | Hashim Z Ilyas A Saleem A Salim A Zarina S | 2009 | Free Radic Biol Med2009，46，8： | 1 |
| 12 | Bioleaching of metals from electronic scrap by moderately thermophilic acidophilic bacteria 显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hydrometallurgy2007，88，1234： | 1 |
| 13 | Parallel recognition of cancer cells using an addressable array of solid-state micropores显示文摘 | Ilyas A Asghar W Kim YT | 2014 | Biosens Bioelectron2014，62，： | 1 |
| 14 | Shrinking of solid-state nanopores by direct thermal heating 显示文摘 | ASGHAR W ILYAS A BILLO J A | 2011 | Nanoseale Research Letters2011，6，1： | 1 |
| 15 | Supporting top-k join queries in relational databases显示文摘 | Ilyas I F Aref W G Elmagarmid A K | 2004 | Proceedings of Vldb Conference2004，13，3： | 1 |
| 16 | Velocity analysis for transversely isotropic media 显示文摘 | Tariq A Ilya T | 1995 | Geophysics1995，60，5： | 1 |
| 17 | Char- acteristics of saccades and vergence in two kinds of se- quential looking tasks 显示文摘 | ILYA V MALINOV A EPELBOIM J B | 2000 | Vision Research2000，40，16： | 1 |
| 18 | Bioleaching of metals from electronic scrap by moderately thermophilic acidophil- ic bacteria显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hvdrometallurv2007，88，14： | 1 |
| 19 | The type of somatic mutation at APC in familial adenomatous polyposis is deter mined by the site of the germline mutation:a new facet to Knudson' s two-hit ' hypothesis显示文摘 | Lamlum H Ilyas M Rowan A | 1999 | Nat Med1999，5，： | 1 |
| 20 | Probabilistic top k and ranking-aggregate queries 显示文摘 | Soliman M A Ilyas I F Chang K C | 2008 | ACM Trans on Database Systems (TODS)2008，33，3： | 1 |
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