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| 1 | Epidemiology of pancreatic cancer显示文摘Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11^(th) most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6%(ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease. | Milena Ilic Irena Ilic | 2016 | World Journal of Gastroenterology2016，22，44： | 95 |
| 2 | Epidemiology of stomach cancer显示文摘Despite a decline in incidence and mortality during the last decades,stomach cancer is one of the main health challenges worldwide.According to the GLOBOCAN 2020 estimates,stomach cancer caused approximately 800000 deaths(accounting for 7.7%of all cancer deaths),and ranks as the fourth leading cause of cancer deaths in both genders combined.About 1.1 million new cases of stomach cancer were diagnosed in 2020(accounting for 5.6%of all cancer cases).About 75%of all new cases and all deaths from stomach cancer are reported in Asia.Stomach cancer is one of the most lethal malignant tumors,with a five-year survival rate of around 20%.There are some well-established risk factors for stomach cancer:Helicobacter pylori infection,dietary factors,tobacco,obesity,and radiation.To date,the most important way of preventing stomach cancer is reduced exposure to risk factors,as well as screening and early detection.Further research on risk factors can help identify various opportunities for more effective prevention.Screening programs for stomach cancer have been implemented in a few countries,either as a national or opportunistic screening of high-risk individuals only.Generally,due to its high aggressiveness and heterogeneity,stomach cancer still remains a severe global health problem. | Milena Ilic Irena Ilic | 2022 | World Journal of Gastroenterology2022，28，12： | 24 |
| 3 | Cancer mortality in Serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis显示文摘Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health problems.The aim of this study was to assess cancer mortality trends in Serbia.Methods:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial data.The age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by Segi.The average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression analysis.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal trends.Results:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in Serbia.Overall cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both sexes.For almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study period.The largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in Serbia.Despite this,these rates place Serbia among the countries with the highest cancer mortality in the world. | Milena Ilic Irena Ilic | 2018 | Cancer Communications2018，38，1： | 7 |
| 4 | Cytomegalovirus immune evasion by perturbation ot endosomal trafficking显示文摘 | Pero Lucin Hana Mahmutefendic Gordana Blagojevic Zagorac Maja Ilic Tomas | 2015 | Cellular & Molecular Immunology2015，12，2： | 5 |
| 5 | Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME显示文摘AIM To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS Celecoxib(1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157(known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine(100 mg/kg ip), as well as NOS blockade [N(G)-nitro-L-arginine methyl ester(L-NAME)](5 mg/kg ip) given alone and/or combined immediately after celecoxib. Gastrointestinal, liver, and brain lesions and liver enzyme serum values in rats were assessed at 24 h and 48 h thereafter. RESULTS This high-dose celecoxib administration, as a result of NO system dysfunction, led to gastric, liver, and brain lesions and increased liver enzyme serum values. The L-NAME-induced aggravation of the lesions was notable for gastric lesions, while in liver and brain lesions the beneficial effect of L-arginine was blunted. L-arginine counteracted gastric, liver and brain lesions. These findings support the NO system mechanism(s), both NO system agonization(L-arginine) and NO system antagonization(L-NAME), that on the whole are behind all of these COX phenomena. An even more complete antagonization was identified with BPC 157(at both 24 h and 48 h). A beneficial effect was evident on all the increasingly negative effects of celecoxib and L-NAME application and in all the BPC 157 groups(L-arginine + BPC 157; L-NAME + BPC 157; L-NAME + L-arginine + BPC 157). Thus, these findings demonstrated that BPC 157 may equally counteract both COX-2 inhibition(counteracting the noxious effects of celecoxib on all lesions) and additional NOS blockade(equally counteracting the noxious effects of celecoxib + L-NAME). CONCLUSION BPC 157 and L-arginine alleviate gastrointestinal, liver and brain lesions, redressing NSAIDs' post-surgery application and NO system involvement. | Domagoj Drmic Danijela Kolenc Spomenko Ilic Lara Bauk Marko Sever Anita Zenko Sever Kresimir Luetic Jelena Suran Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，29： | 2 |
| 6 | Colorectal cancer mortality trends in Serbia during 1991–2010:an age-period-cohort analysis and a joinpoint regression analysis显示文摘Background: For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, prior to the introduction of population-based screening.Methods: Joinpoint regression analysis was used to estimate average annual percent change(AAPC) with the corresponding 95% confidence interval(CI). Furthermore, age-period-cohort analysis was performed to examine the effects of birth cohort and calendar period on the observed temporal trends.Results: We observed a significantly increased trend in colorectal cancer mortality in Serbia during the study period(AAPC = 1.6%, 95% CI 1.3%–1.8%). Colorectal cancer showed an increased mortality trend in both men(AAPC –2.2%) and women(AAPC rend of colorectal cancer mo= 2.0%, 95% CI 1.7%= 1.0%, 95% CI 0.6%–1.4%). The temporal trtality was significantly affected by birth cohort(P < 0.05), whereas the study period did not significantly affect the trend(P = 0.072). Colorectal cancer mortality increased for the first several birth cohorts in Serbia(from 1916 to 1955), followed by downward flexion for people born after the 1960 s. According to comparability test, overall mortality trends for colon cancer and rectal and anal cancer were not parallel(the final selected model rejected parallelism, P < 0.05).Conclusions: We found that colorectal cancer mortality in Serbia increased considerably over the past two decades. Mortality increased particularly in men, but the trends were different according to age group and subsite. In Serbia, interventions to reduce colorectal cancer burden, especially the implementation of a national screening program, as well as treatment improvements and measures to encourage the adoption of a healthy lifestyle, are needed. | Milena Ilic Irena Ilic | 2016 | Chinese Journal of Cancer2016，35，10： | 2 |
| 7 | Generation strategies for gaming transmission constraints: will the deregulated electric power market be an oligopoly? 显示文摘 | Younes Z Ilic M | 1999 | Decision Support Systems1999，24，3： | 2 |
| 8 | International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis显示文摘BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three decades.METHODS A descriptive epidemiological study was done.Pancreatic cancer incidence and mortality data were obtained from the database of the World Health Organization.Analysis of pancreatic cancer incidence and mortality during 2020 was performed.The age-standardized rates(ASRs,expressed per 100000)were presented.To estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Additionally,analysis was performed by sex and age.In this paper,the trend analysis included only countries with high and medium data quality.RESULTS A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in 2020.In both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific Region.In both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia Region.The general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed period.Out of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without significance.Out of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasing in both sexes only in Canada and Mexico.CONCLUSION Further research is needed to explain the cause of large international differences in incidence and mortality trends of pancreatic cancer in last three decades. | Irena Ilic Milena Ilic | 2022 | World Journal of Gastroenterology2022，28，32： | 2 |
| 9 | The energy of unitary cayley graphs显示文摘 | ILIC'A | 2009 | Linear Algebra andits Applications2009，431，： | 1 |
| 10 | Newresults on the energy of integral circulant graphs显示文摘 | ILIC'A BASIC'M | 2011 | Applied Mathematics and Computation2011，218，： | 1 |
| 11 | Nutritive characteristics of probiotie quarg as influenced by type of starter显示文摘 | Djurie M S Ilicic M D Milanovie S D et ai | 2007 | Aeta Period Teehnol2007，38，： | 1 |
| 12 | Electrical and elastic properties of Cu-W graded material produced by vibro compaction显示文摘 | JANKOVIC' ILIC' D FISCINA J GONZALEZ-OLIVER C J R | 2008 | Journal of Materials Science2008，，43： | 1 |
| 13 | A Steady state Voltage Monitoring and Control Algorithm Using Localized Least Square Minimization of Load Voltage Deviations显示文摘 | Zobian A Ilic M D | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 14 | Unbundling of transmission and ancillary services: Part I -- Technical Issue, Par II -- Cost-based pricing framework 显示文摘 | Ilic M D | 1997 | IEEE Transactions on Power Systems1997，12，53： | 1 |
| 15 | Lipid abnormalities in elderly patients with subclinical hyperthyroidism显示文摘 | Caparevic Z Stojanovic D Ilic V | 2003 | Med Preg12003，56，： | 1 |
| 16 | Video image processor for wood anatomicalquantification 显示文摘 | Ilic J Hillis WE | 1983 | Holzforschung1983，37，： | 1 |
| 17 | Nosocomial infections prevalence study in a Serbian university hospital 显示文摘 | Ilic M Markovic-Denic L | 2009 | Vojnosanit Pregl2009，66，11： | 1 |
| 18 | Immunohistochemi- cal analysis of the expression of MAGE-A and NY-ESO- 1 cancer/testis antigens in diffuse large B-cell testicular lymphoma 显示文摘 | Hudolin T Kastelan Z Ilic I | 2012 | J Transl Med2012，11，21： | 1 |
| 19 | FAK integrates growth factor and integrin signals to promote cell migration显示文摘 | Sieg D J Hauck C R Ilic D | 2000 | Nat Cell Biol2000，2，5： | 1 |
| 20 | Modeling of future cyber-physical energy systems for distributed sensing and control显示文摘 | Ilic M D Xie L Khan U A | 2010 | IEEE Transactions on Systems Man and Cybernetics-Part A:Systems and Humans2010，40，4： | 1 |
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