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| 1 | Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities显示文摘Acute myocardial infarction(AMI) is the leading cause of death worldwide. Its associated mortality, morbidity and complications have significantly decreased with the development of interventional cardiology and percutaneous coronary angioplasty(PCA) treatment, which quick-ly and effectively restore the blood flow to the area previously subjected to ischemia. Paradoxi-cally, the restoration of blood flow to the ischemic zone leads to a massive production of reactive oxygen species(ROS) which generate rapid and severe damage to biomolecules, generating a phenomenon called myocardial reperfusion injury(MRI). In the clinical setting, MRI is associated with multiple complications such as lethal reperfusion, no-reflow, myocardial stunning, and reperfusion arrhythmias. Despite significant advances in the understanding of the mechanisms accounting for the myocardial ischemia reperfusion injury, it remains an unsolved problem. Although promising results have been obtained in experimental studies(mainly in animal models), these benefits have not been translated into clinical settings. Thus, clinical trials have failed to find benefits from any therapy to prevent MRI. There is major evidence with respect to the contribution of oxidative stress to MRI in cardiovascular diseases. The lack- of consistency between basic studies and clinical trials is not solely based on the diversity inherent in epidemiology but is also a result of the methodological weak-nesses of some studies. It is quite possible that pharmacological issues, such as doses, active ingredients, bioavailability, routes of administration, co-therapies, startup time of the drug intervention,and its continuity may also have some responsibility for the lack- of consistency between different studies. Furthermore, the administration of high ascorbate doses prior to reperfusion appears to be a safe and rational therapy against the development of oxidative damage associated with myocardial reperfusion. In addition, the association with N-acetylcysteine(a glutathione donor) and deferoxamine(an iron chelator) could improve the antioxidant cardioprotection by ascorbate, mak-ing it even more effective in preventing myocardial reperfusion damage associated with PCA following AMI. | Jaime González-Montero Roberto Brito Abraham IJ Gajardo Ramón Rodrigo | 2018 | World Journal of Cardiology2018，10，9： | 56 |
| 2 | 纤维蛋白原检测的指南显示文摘英国血液学界通常通过纤维蛋白原的测定来判断纤维蛋白量的降低和质的异常,评估出血危险性.纤维蛋白原的升高通常预示各种缺血性事件的存在,建议进行纤维蛋白原检测就是基于这种观点. | Mackie IJ Kitchen S Machin SJ Lowe SDO 董宁征 | 2004 | 国外医学(输血及血液学分册)2004，27，2： | 11 |
| 3 | 阿司匹林——预防关节置换术后肺栓塞的新选择?显示文摘对于施行全关节置换术(total joint arthroplasty,TJA)的患者,术后预防静脉血栓(venous thromboembolism,VTE)的理想方法目前仍不明确。华法林是常用的VTE预防药物,尽管有效,但患者肺栓塞(pulmonary embolism,PE)、深静脉血栓(deep vein thrombosis,DVT)发生率及出血风险明显提高,需要定期监测。 | Raphael IJ Tischler EH Huang R 杨庆磊 尹庆水 | 2014 | 中国骨科临床与基础研究杂志2014，6，3： | 7 |
| 4 | 结合珠蛋白2的变异促进脑卒中幸存者过早因心血管病死亡显示文摘结合珠蛋白(Haptoglobin,Hp)是一种急性期血浆蛋白,可保护组织免受氧化损伤。它存在2个变异等位基因(hp1/hp2),产生具有不同生化特性和不同功能的3种蛋白质异构体。先前研究发现, | Ij?s P Melkas S Saksi J Jula A Jauhiainen M Oksala N Pohjasvaara T Kaste M Karhunen PJ Lindsberg P Erkinjuntti T 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 5 | A community study of sleepdisordered breathing in middle aged Chinese men in Hong Kong显示文摘 | Ip M Lam B Lauder IJ | | 0，，： | 2 |
| 6 | A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma:a randomized trial显示文摘 | Hsu C Hsiung CA Su IJ | | Hepatology0，，： | 2 |
| 7 | 有症状门诊病人深静脉血栓形成的诊断,临床评价和D-二聚体分析可能减少对影像学诊断的需要显示文摘深静脉血栓形成(DVT)的年发病率为48~182/10万,一般估计为1/1000.DVT病死率为1%~5%,发病率和病死率与年龄密切相关.慢性疼痛、肿胀、偶尔腿部皮肤溃疡等血栓后综合征见于1/3发生过DVT的患者.血栓后综合征可出现较早,也可迟至10年才出现,总的发病率为2年23%,5年28%.患者如使用弹力加压袜至少2年以上,腿部病变的发生率可减半.对DVT及其后果警惕性的提高使得要做检查的患者数量增加,其中许多人属于低风险性,反映在检查报告中DVT阳性诊断率下降. | Keeling DM Mackie IJ Moody A Watson HG 吴淑燕 王兆钺 | 2004 | 国外医学(输血及血液学分册)2004，27，5： | 2 |
| 8 | Anti-inflammatory activity of Polygonum bistorta,Guaiacum officinale and Hamamelis virginiana in rats 显示文摘 | Duwiejua M Zeitlin IJ Waterman PG | 1994 | J Pharm Pharmcol1994，46，4： | 2 |
| 9 | The anti-inflammatory compounds of Polygonum bistorta:isolation and characterization 显示文摘 | Duwiejua M Zeitlin IJ Gray AI | 1999 | Planta Med1999，65，： | 2 |
| 10 | 弓形虫感染引起小胶质细胞与神经元的接触以及细胞体周边抑制性突触丧失显示文摘大脑内的感染和炎症会引起神经元连通性和功能的改变。细胞内的原生动物寄生虫,弓形虫,是一种感染脑部的病原体,可引起脑炎和癫痫发作。这种寄生虫的持续感染还与行为改变和发生精神疾病(包括精神分裂症)的风险增加有关。目前来自人类和小鼠模型的研究证据表明,癫痫发作和精神分裂症均由抑制性突触的丧失或功能障碍引起。与此相符,我们最近报道了持续性弓形虫感染改变谷氨酸脱羧酶67(GAD67)的分布,该酶在抑制性突触中催化GABA的合成。这些变化可能反映突触前装置在抑制性神经元中的重新分布或抑制性神经末梢的丧失。为了直接评估后者的可能性,我们采用序列块面扫描电子显微镜(SBFSEM)并量化寄生虫感染后新皮质和海马中的细胞体周边抑制性突触。持续感染不仅导致明显的细胞体周边突触丧失,而且还诱导髓样来源的细胞对神经元细胞体的包封。免疫组织化学、遗传和超微结构分析显示,这些髓样来源的细胞包括活化的小胶质细胞。最后,超微结构分析确定了包膜于细胞体周围神经末梢的髓样来源的细胞,提示它们可能会主动置换或吞噬突触元件。因此,这些结果表明,活化的小胶质细胞有助于寄生虫感染后细胞体周围抑制突触损失,并对于弓形虫的持续感染可能如何导致癫痫发作和精神疾病提供了一种新的机制。 | Carrillo GL Ballard VA Glausen T Boone Z Teamer J Hinkson CL Wohlfert EA Blader IJ Fox MA 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，3： | 2 |
| 11 | Recombinant Paragonimus westermani yolk ferritin is a useful serodiagnostic antigen 显示文摘 | Kim TY Joo IJ Kang SY | 2002 | J Infect Dis2002，185，9： | 2 |
| 12 | Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease显示文摘 | Chung YB Kong Y Joo IJ | 1995 | J Parasitol1995，81，2： | 1 |
| 13 | Metastasis results from preexisting variant cells within a malignant tumor显示文摘 | Fidler IJ Kripke ML | 1977 | Science1977，197，4306： | 1 |
| 14 | Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis 显示文摘 | Diel IJ Solomayer EF Seibel MJ | 1999 | Clin Cancer Res1999，5，12： | 1 |
| 15 | Csirhiuorrhoea; the plale of endoscopic sinus surgery显示文摘 | Marshall AH Jous NS Robertsou IJ | 2001 | Br J Neuro surg2001，15，： | 1 |
| 16 | Globus pharyngis:Development of a symptom assessment scale显示文摘 | Deary IJ Wilson JA Harris MB | 1995 | J Psychosom Res1995，39，： | 1 |
| 17 | Muhimodality gynecomastia repair by cross-chest power-assisted superficial liposuetion combined with endoscopic-assisted pull-through excision 显示文摘 | Ramon Y Fodor L Paled IJ | 2005 | Ann Plast Surg2005，55，6： | 1 |
| 18 | Phylogeny and classification of Aedini (Diptera: Culicidae) based on morphological characters of all life stages 显示文摘 | Reinert JF Harbach RE Kitching IJ | 2004 | Zool J Linnnean Soc2004，142，： | 1 |
| 19 | A comparative study of the trochanteric fractures treated with Gamma nail or the proximal nail显示文摘 | Herrera A Domingo IJ Calvo A | 2002 | Int Orthop2002，26，： | 1 |
| 20 | Metastatic breast cancer: Clinical course, prognosis and therapy related to the first site of metastasis 显示文摘 | Solomayer EF Diel IJ Meyberg GC | 2000 | Breast Cancer Res Treat2000，59，3： | 1 |
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