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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Differential interactions among isolates of peanut stunt Cucumovirus and its satellite RNA显示文摘 | Vicente M Ignacio M Emilio R C | 1998 | Journal of General Virology1998，79，： | 1 |
| 3 | Fiber-optic pH-sensors in long period fiber gratings using electrostatic self assembly显示文摘 | JESUS M C IGNACIO D V IGNACIO R M | 2007 | Opt Lett2007，32，1： | 1 |
| 4 | Health-related quali- ty of life in coronary heart disease compared to norms in Spanish population显示文摘 | Maria S T Soledad M C Ignacio R D | 2004 | Quality of Life Research2004，13，8： | 1 |
| 5 | Nanodeposition of materials with complex refractive index in long-period fiber gratings显示文摘 | IGNAClO D V IGNACIO R M | 2005 | Journal of Lightwave Technoledge2005，23，12： | 1 |
| 6 | Deposition of coatings on long period fiber gratings: tunnel effect analogy 显示文摘 | IGNACIO D V IGNACIO R M FEDER J A | 2006 | Optical and Quantum Electronics2006，38，： | 1 |
| 7 | Coherent Population Transfer in Three -level A Systems by Chirped Laser Pulses: Minimization of the Intermediate-level Population显示文摘 | Ignacio R S Vladimir S M Chang B Y | 1999 | Phys Rev A1999，59，： | 1 |
| 8 | The design of rainfall networks in time and space显示文摘 | IGNACIO R I JOSE M M | 1974 | Water Resources Research1974，10，： | 1 |
| 9 | Result of a phase Ⅱ concurrent chemotherapy study using three dimensional conformal radiotherapy with cisplatin and oral etoposide in stage Ⅲ non small cell lung cancer显示文摘 | Chen L M Ignacio L Jacobs R | 1999 | Radiat Oncol Investig1999，7，1： | 1 |
| 10 | Lukas,sex specificity in methadone analgesia in the rat:a population pharmacokinetic and pharmacodynamic approach显示文摘 | Monica R Angeles Carlos M Ignacio O | 2002 | Pharm Res2002，19，6： | 1 |
| 11 | Design of humidity sensor based on tapered optical fibers 显示文摘 | JesOs M Corres Francisco J Arregui Ignacio R Matias | 2006 | Journal of Lightwave Technology2006，24，11： | 1 |
| 12 | Optimization of sensitivity in long period fiber gratingswith overlay deposition显示文摘 | IGNACIO D V IGNACIO R M FRANCISCO J A | 2005 | Optics Express2005，13，1： | 1 |
| 13 | Optical Fiber Humidity Sensors Using Nanostructured Coatings of SiO2 Nanoparticles显示文摘 | Jesus M Corres Ignacio R Matias Miguel Hernaez | 2008 | IEEE Sensors Journal2008，8，3： | 1 |
| 14 | Volumetric reconstruction and interactive rendering of trees from photographs显示文摘 | Alex R Ignacio M Geoge D | 2004 | ACM Transactions on Graphics (SIGGRAPH Conference Proceedings)2004，23，3： | 1 |
| 15 | Optimization ofSensitivity in Long Period Fiber Gratings with OverlayDeposition显示文摘 | Ignacio D V Ignacio R M Francisco J A | 2005 | Optics Express2005，13，1： | 1 |
| 16 | Influence oncladding mode distribution of overlay deposition on long-period fiber gratings 显示文摘 | Ignacio D V Ignacio R M Francisco J A | 2006 | Optical Society of America2006，23，3： | 1 |
| 17 | Tourist satisfaction: a cognitive-affective model显示文摘 | Ignacio R B Héctor S M | 2008 | Annals of Tourism Research2008，35，2： | 1 |
| 18 | Voltammetric study of 2 - methy - 4, 6 - dinitrophenol at a modified carbon paste electrode显示文摘 | Maria del M C R Ignacio N R Jose L H H de C | 1998 | Analytica Chimica Acta1998，370，： | 1 |
| 19 | Pglycoprotein in clinical cardiology 显示文摘 | IGNACIO R M D DARRELL R ABERNETHY M D | 1999 | Circulation1999，99，： | 1 |
| 20 | The moderati- ng effect of environmental uncertainty on the relation ship between real options and technological innova- tion in high-tech finns显示文摘 | Antonio J V Ignacio T Antonia R M | 2012 | Technovation2012，32，910： | 1 |
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