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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Cerebral blood flow and oxygen metabolism in patients with progessive dementia and amyotrophic lateral sclerosis显示文摘 | Tanaka M Ichiba T Konda S | 2003 | Neurol Res2003，25，4： | 2 |
| 3 | Three cases ofpulmonary mucoepidermoid carcinoma显示文摘 | NAGAHIRO I ANDO A ICHIBA S | 2000 | Kyobu Geka2000，53，： | 1 |
| 4 | PhysicalProperties of Noodles显示文摘 | Torn Shimizu Hideaki Fakawa Akiyoshi Ichiba | 1958 | Cereal chem1958，35，1： | 1 |
| 5 | Leukocyte 8- hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure 显示文摘 | Zhang J Ichiba M Hanaoka T | 2003 | Int Arch Occup Environ Health2003，76，7： | 1 |
| 6 | Mitogenic activity of tra-cheal effluents from premature infants with chronic lung disease显示文摘 | SAITO M ICHIBA H YOKOI T | 2004 | Pediatr Res2004，55，6： | 1 |
| 7 | STAT3 is required for the gp130-mediated full activation of the c-myc gene显示文摘 | Kiuchi N Nakajima K Ichiba M | 1999 | J Exp Med1999，189，1： | 1 |
| 8 | Clinical usefulness of diffusion weighted imaging using low and high b-values to detect rectal cancer 显示文摘 | Hosonuma T Tozaki M Ichiba N | 2006 | Magn Reson Med Sci2006，5，4： | 1 |
| 9 | The Relationship between Disc Brake Squeal and Friction Characteristics显示文摘 | Ichiba Y Nagasawa Y | | 0，，02： | 1 |
| 10 | Aromatic DNA adducts in coke- oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes显示文摘 | Zhang J Ichiba M Feng Y | 2000 | Int Arch Occ Env Hea2000，73，： | 1 |
| 11 | New manzamine alkaloids from a sponge of the genus Xestospongia 显示文摘 | Ichiba T Sakai R Kohmoto S | 1988 | Tetrahedron Lett1988，29，： | 1 |
| 12 | Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes 显示文摘 | ZHANG J ICHIBA M HARA K | 2001 | Occup Environ Med2001，58，11： | 1 |
| 13 | Amniotic fluid transforming growth factor-betal and the risk for the development of neonatal bronchopulmonary dysplasia显示文摘 | Ichiba H Saito M Yamano T | 2009 | Neonatology2009，96，3： | 1 |
| 14 | Experimental study of partial liquid ventilation in the setting of acute respiratory failure induced by sea water lung lavage in rabbits显示文摘 | Sawada S Ichiba S Itano H | 1998 | Acta Med Okayama1998，52，： | 1 |
| 15 | Three cases of pulmonary mucoepidermoid carcinoma显示文摘 | Nagahiro I Ando A Ichiba S | 2000 | Kyobu Geka2000，53，8： | 1 |
| 16 | Surfactant proteins A and D :disease markers 显示文摘 | Kuroki Y Takahashi H iChiba H | 1998 | Biochim Biophys Acta1998，1408，23： | 1 |
| 17 | Nationwide survey of neonatal transportation practices in Japan显示文摘 | Hiroma T Ichiba H Wada K | 2016 | Pediatr Int2016，58，4： | 1 |
| 18 | Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate显示文摘 | Ichiba H Yokoi T Tamai H | 2006 | Pediatr Int2006，48，1： | 1 |
| 19 | Randomized controlled trial of magnesium sulfate infusion for severe birth asphyxia显示文摘 | Ichiba H Tamai H Negishi H Ueda T Kim TJ Sumida Y | 2002 | Pediatr Int2002，44，5： | 1 |
| 20 | Antihy- pertensive effect of an extract of Passiflora edulis rind inspontaneously hyertensive rats 显示文摘 | ICHIMURA T YAMANAKA A ICHIBA T eta| | 2006 | Bioscience Biotech- nology and Biochemistry2006，70，3： | 1 |
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