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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 3 | Management of immunosuppressant agents following livertransplantation:Less is more显示文摘Immunosuppression in organ transplantation was revolutionary for its time,but technological and population changes cast new light on its use.First,metabolic syndrome(MS) is increasing as a public health issue,concomitantly increasing as an issue for post-orthotopic liver transplantation patients;yet the medications regularly used for immunosuppression contribute to dysfunctional metabolism.Current mainstay immunosuppression involves the use of calcineurin inhibitors;these are potent,but nonspecifically disrupt intracellular signaling in such a way as to exacerbate the impact of MS on the liver.Second,the impacts of acute cellular rejection and malignancy are reviewed in terms of their severity and possible interactions with immunosuppressive medications.Finally,immunosuppressive agents must be considered in terms of new developments in hepatitis C virus treatment,which undercut what used to be inevitable viral recurrence.Overall,while traditional immunosuppressive agents remain the most used,the specific side-effect profiles of all immunosuppressants must be weighed in light of the individual patient. | Mustafa S Ascha Mona L Ascha Ibrahim A Hanouneh | 2016 | World Journal of Hepatology2016，8，3： | 5 |
| 4 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 5 | Microstructure,Properties and Wear Behaviors of (Ni_3Al)_p Reinforced Cu Matrix Composites显示文摘Pure copper and its composites reinforced with Ni 3 Al particles were produced by powder metallurgy(PM).Ni 3 Al powders were produced by mechanical ball milling from vacuum arc melted compounds.The Ni 3 Al powders were characterized by X-ray diffraction(XRD).The microscopy examinations revealed that the Ni 3 Al particles were distributed uniformly in the matrix.The effects of the particle fraction on the density,electrical conductivity,strength and dry sliding wear resistance of composite were investigated.It was found that the density and electrical conductivity of the composites decrease while the compression yield strength and wear resistance of composites increase with an increase in the particle fraction.The dry sliding wear tests were performed with pin-on-disk geometry.After sliding wear tests,the worn surfaces were examined by scanning electron microscopy(SEM) equipped with an energy dispersive X-ray spectrometer(EDS).Results have shown that the wear mechanism is oxidative and adhesive. | Ibrahim elikyrek Nese .Krpe Tugba ler Remzi Grler | 2011 | Journal of Materials Science & Technology2011，27，10： | 2 |
| 6 | Advances in the management of infertility in men with spinal cord injury显示文摘结合一根针的绳索受伤男搭挡要求帮助射精技术收集当时能进一步的精液在各种各样的帮助繁殖技术方法使用完成怀孕。不管原因或损害的水平支撑针的绳索损害的人的多数不能在性交期间射精。仅仅一个小少数能由手淫射精。阴茎振动刺激和 electroejaculation 是过去常检索精子的二个很普通的方法。象 prostatic 按摩和另外的药的附属物申请那样的另外的技术能被使用,但是结果是不一致的。如果所有另外的方法失败,外科的精子检索应该被看作最终手段。特殊注意必须由于在损害的水平下面源于刺激的自治 dysreflexia 的风险与 T6 和损害的喙的层次对病人被给予。如果,膀胱准备应该在刺激前被执行后退射精被期望。可勃起的机能障碍在针的绳索是无所不在的伤害了人口,但是容易通常被管理并且不在这些人提出一个障碍到精液检索。有针的绳索损害的人的精液分析参数不管检索的方法为这张人口是唯一的,通常作为正常精子集中,但是反常地介绍低精子活动性和生存能力。当精子检索在这张人口被需要时,强调应该被放在开始在诉诸更多的先进、侵略的外科的过程前试试阴茎振动刺激或 electroejaculation 的简单方法上。 | Emad Ibrahim Nancy L Brackett Charles M Lynne | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 7 | Identification,cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human显示文摘 | Hart AH Hartley L Ibrahim M | 2004 | Dev Dyn2004，230，1： | 1 |
| 8 | Radi- cal resection of fibrous dysplasia involving the anterior cranial base 显示文摘 | ELDALY F A NOUR L IBRAHIM P | 2012 | Neurosurgery Quarterly2012，22，： | 1 |
| 9 | Bone and cancer:the osteon-cology显示文摘 | Ibrahim T Mercatali L Amadori D | | 0，，02： | 1 |
| 10 | A systematic review of clinical and surgical predictors of complications following surgery for degenerative cervical myelopathy 显示文摘 | TETREAULT L IBRAHIM A CTP | 2015 | J Neurosurg Spine2015，25，9： | 1 |
| 11 | Pharmacokinetics of inhaled rifampicin porous particles for tuberculosis treatment: insight into rifampicin absorption from the lungs of guinea pigs显示文摘 | Garcia Contreras L Sung J Ibrahim M | 2015 | Mol Pharrn2015，12，8： | 1 |
| 12 | Systemic Naloxone Infusion May Trigger Spasticity in Patients With Spinal Cord Injury: Case Series显示文摘 | Nancy L Brackett Emad Ibrahim Andrei Krassioukov | 2007 | J Spinal Cord Med2007，30，： | 1 |
| 13 | Immunosuppmssive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L 显示文摘 | Pereira R L Ibrahim T Lucchetti L | 1999 | Immunopharmacology1999，43，1： | 1 |
| 14 | Early versus late enteral feeding of mechanically ventilated patients:results of a clinical trial显示文摘 | IBRAHIM E H MEHRINGER L PRENTICE D | 2002 | J Parenter Enteral Nutr2002，26，3： | 1 |
| 15 | Comparative evalua-tion of two rapid field tests for malaria diagnosis: partec rapid malaria test(R) and binax Now(R) malaria rapid diagnostic test显示文摘 | Nkrumah B Acquah SE Ibrahim L | 2011 | BMC Infect Dis2011，23，11： | 1 |
| 16 | Experimental investigation of friction-induced noise in disc brake systems显示文摘 | Ibrahim R A Madhavan S Qiao S L etal | 2000 | International Journal of Vehicle Design2000，23，34： | 1 |
| 17 | Interferomettic technique to measure biomechanical changes in the cornea induced by refractive surgery 显示文摘 | Jaycock PD Lobo L Ibrahim J Tyrer J Marshall J | 2005 | J Cataract Refract Surg2005，31，1： | 1 |
| 18 | Replication of ketamine’s antidepressant efficacy in bipolar depression:a randomized controlled add-on trial显示文摘 | Zarate CA Jr Brutsche NE Ibrahim L | 2012 | Biol Psychiatry2012，71，： | 1 |
| 19 | Interactive effects of nitrogen and water availabilities on gas exchange and whole-plant carbon allocation in poplar显示文摘 | Ibrahim L Proe M F Cameron A D | 1998 | Tree Physiolo- gy1998，18，7： | 1 |
| 20 | Clinical Staging for Sleep-disordered Breathing显示文摘 | Ibrahim H Bass L | 2002 | Otolaryngology-Head and Neck Surgery2002，127，1： | 1 |
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