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| 1 | Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma显示文摘 | Brian I.Carr VenkateswarluKondragunta Shama C.Buch Robert A.Branch | 2010 | Cancer2010，，5： | 2 |
| 2 | Economic evaluation of sorafenib in unresectable hepatocellular carcinoma显示文摘 | Brian I.Carr StuartCarroll NoemiMuszbek KathleenGondek | 2010 | Journal of Gastroenterology and Hepatology2010，，11： | 1 |
| 3 | Vitamin K enhancement of sorafenib‐mediated HCC cell growth inhibition in vitro and in vivo显示文摘 | GangWei MeifangWang TerryHyslop ZiqiuWang Brian I.Carr | 2010 | Int J Cancer2010，，12： | 1 |
| 4 | Comparison of patients with hepatitis B virus-associated hepatocellular carcinoma:Data from two hospitals from Turkey and China显示文摘Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different populations.The study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and China.Methods:Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital(n=578)and Inonu University Hospital(n=359)between January 2002 and December 2020,and the liver function and HCC characteristics were compared.Continuous variables were compared using Student's t-test or Mann-Whitney U test and categorical variables were compared using the χ^(2) test or Fisher's exact test.Results:The patients in the Turkish cohort had significantly worse Child-Pugh scores(Child-Pugh A:38.3%vs.87.9%;Child-Pugh B:40.3%vs.11.1%;Child-Pugh C:21.4%vs.1.0%;p<0.001)and significantly higher levels of aspartate aminotransferase(66.5[38.0−126.0]vs.36.0[27.0-50.0]IU/L;p<0.001),alanine aminotransferase(47.5[30.0−87.3]vs.33.0[24.0−45.0]IU/L;p<0.001),total bilirubin(20.8[13.7−39.3]vs.17.9[13.8−24.0]mg/dL;p<0.001),and lower albumin levels(32.0[26.0-39.0]vs.40.0[36.1-43.8]g/L;p<0.001)than patients in Chinese cohort.The tumor characteristics showed the Barcelona Clinic Liver Cancer(BCLC)score(BCLC 1:5.1%vs.71.8%;BCLC 2:48.7%vs.24.4%;BCLC 3:24.4%vs.3.8%;BCLC 4:21.8%vs.0;all p<0.001),maximum tumor diameter(5.0[3.0-9.0]vs.3.5[2.5−6.0]cm;p<0.001),alpha-fetoprotein values(27.7 vs.13.2 ng/mL;p<0.001),and percentage of patients with portal vein tumor thrombus(33%vs.6.1%;p<0.001)were all significantly worse in the Turkish cohort compared with Chinese cohort.Conclusions:HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort. | Brian I.Carr Fajuan Rui Volkan Ince Sezai Yilmaz Xinya Zhao Yuemin Feng Jie Li | 2023 | Portal Hypertension & Cirrhosis2023，2，4： | 0 |
| 5 | Discordance among aggressiveness characteristics of hepatocellular carcinoma:Portal vein thrombosis and multifocality,related to tumor size,but not to serum alpha-fetoprotein level显示文摘Background and aims:Hepatocellular carcinoma(HCC)is characterized by several clinically important prognostic parameters,including portal vein thrombosis(PVT),tumor multifocality,and serum alphafetoprotein(AFP)levels,in addition to maximum tumor diameter(MTD).However,associations among these parameters have not been thoroughly examined.Thus,the study aimed to investigate the correlations among these HCC characteristics in a prospectively collected database.Methods:An 8080 HCC patient database derived from our weekly HCC council meeting was examined with respect to the correlations at baseline patient presentation between increases in MTD and changes in the percentage of patients with PVT,multifocality,or AFP levels.Results:The percentage of patients with PVT and with multifocality(tumor nodule numbers≥3)significantly increased with enlarging MTD,regardless of the serum AFP level,showing the independence of PVT and multifocality on AFP.The percentage of patients with multifocality increased with enlarging MTD,in the presence or absence of PVT,showing the independence of multifocality from PVT.Therefore,discordance was found between different tumor parameters.Conclusions:A statistically significant association was found between PVT and MTD and between multifocality and MTD,all three of which are independent of AFP.PVT and multifocality appeared to be independent of each other.Although PVT and multifocality were independent of AFP,they were also augmented with high serum AFP levels.The results suggest the possibility of multiple pathways of tumor progression in the later stages of HCC development. | Brian I.Carr Vito Guerra Volkan Ince Burak Isik Sezai Yilmaz | 2023 | Liver Research2023，7，3： | 0 |
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