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| 1 | Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia显示文摘AIM To evaluate factors associated with Clostridium difficile infection (CDI) and outcomes of CDI in the myelodysplastic syndrome(MDS) and acute myeloid leukemia (AML) population.METHODS After IRB approval,all MDS/AML patients hospitalized at the University of Maryland Greenebaum Comprehensive Cancer Center between August 2011 and December 2013 were identified.Medical charts were reviewed for demographics,clinical information,development of CDI,complications of CDI,and mortality.Patients with CDI,defined as having a positive stool PCR done for clinical suspicion of CDI,were compared to those without CDI in order to identify predictors of disease.A t-test was used for comparison of continuous variables and chisquare or Fisher's exact tests were used for categorical variables,as appropriate.RESULTS Two hundred and twenty-three patients (60.1% male,mean age 61.3 years,13% MDS,87% AML) had 594 unique hospitalizations during the study period.Thirtyfour patients (15.2%) were diagnosed with CDI.Factors significantly associated with CDI included lower albumin at time of hospitalization (P < 0.0001),prior diagnosis of CDI (P < 0.0001),receipt of cytarabine-based chemotherapy (P = 0.015),total days of neutropenia (P = 0.014),and total days of hospitalization (P = 0.005).Gender (P = 0.10),age (P = 0.77),proton-pump inhibitor use (P = 0.73),receipt of antibiotics (P = 0.66),and receipt of DNA hypomethylating agent-based chemotherapy (P = 0.92) were not significantly associated with CDI.CONCLUSION CDI is common in the MDS/AML population.Factors significantly associated with CDI in this population include low albumin,prior CDI,use of cytarabine-based chemotherapy,and prolonged neutropenia.In this study,we have identified a subset of patients in which prophylaxis studies could be targeted. | Kamini Shah Bryan F Curtin Christopher Chu Daniel Hwang Mark H Flasar Erik von Rosenvinge | 2017 | World Journal of Clinical Oncology2017，8，5： | 3 |
| 2 | Ultrasonic tissue characterization evaluates myocardial viability and ischemia in patients with coronary artery disease显示文摘 | LIN L C YEN R F HWANG J J | 2000 | Ultrasound Med Biol2000，26，5： | 2 |
| 3 | Trusted P2P transactions with fuzzy reputation aggregation 显示文摘 | SONG S S HWANG K ZHOU R F | 2005 | IEEE Internet Computing2005，9，6： | 1 |
| 4 | Design and implementation of differential cascode voltage switch with pass-gate (DCVSPG) logic for high-performance digital systems显示文摘 | Hwang W | 1997 | IEEE Journal of Solid-State Circuits1997，32，4： | 1 |
| 5 | Co-evolutionary hybrid differential evolution for mixed-integer optimization problems显示文摘 | Lin Y C Hwang K S Wang F S | 2001 | Engineering Optimization2001，33，6： | 1 |
| 6 | An investigation on susceptibility of banana clones to fusarial wilt,freckle and marginal scorch disease in Taiwan显示文摘 | Hwang S C Chen C L Wu F L | 1984 | Plant Protection Bulletin1984，26，： | 1 |
| 7 | Co-evolutionary hybrid differ- ential evolution for mixed-integer optimization problems显示文摘 | Lin Y C Hwang K S Wang F S | 2001 | Engi- neering Optimization2001，33，6： | 1 |
| 8 | A new decomposition algorithm for rearrangeable clos intercon- neetion networks 显示文摘 | LEE H Y HWANG F K CAPINELLI J | 1996 | IEEE Trans Comm1996，44，11： | 1 |
| 9 | Vibrio alginolyticus, a tetrodotoxin-producing bacterium, in the intestines of the fish Fugu vermicularis vermicularis 显示文摘 | Noguchi T Hwang D F Arakawa O | 1987 | Marine Biology1987，94，： | 1 |
| 10 | A construction of pooling designs with some happy surprises显示文摘 | YACHKOV A D HWANG F K MACULA A | 2005 | J Comput Biol2005，12，8： | 1 |
| 11 | Influence of environmental and nutritional factors on growth,toxicity,and toxin profile of dinoflagellate Alexandrium minutum显示文摘 | Hwang D F Lu Y H | 2000 | Toxicon2000，38，： | 1 |
| 12 | A multiplex PCR assay for species identification of raw and cooked bonito显示文摘 | LIN W F HWANG D F | 2008 | Food Control2008，19，9： | 1 |
| 13 | A Construction of Pooling Designs with Some Happy Surprises 显示文摘 | ErYACHKOV A G HWANG F K MACULA A J | 2005 | Journal of Computational Biology2005，12，： | 1 |
| 14 | FPGA-based intelligent-complementary sliding-mode control for PMLSM servo-drive system 显示文摘 | Lin F J Hwang J C Chou P H | 2010 | IEEE Transactionson Power Electronics2010，25，10： | 1 |
| 15 | Clathrin- mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis 显示文摘 | Dhonukshe P Aniento F Hwang I | 2007 | Curr Biol2007，17，： | 1 |
| 16 | Viable counts,characteristic evaluation for commercial lactic acid bacteria products 显示文摘 | LAN WH HWANG C F CHEN L W | 2006 | Food Microbiol2006，23，1： | 1 |
| 17 | Inhibition of platelet de rived growth factor receptor phosphorylation by STI571(Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model显示文摘 | HWANG R F YOKOI K BUCANA C D | 2003 | Clin Cancer Res2003，9，17： | 1 |
| 18 | Diversity and regulation of plant Ca2+ pumps:insights from expression in yeast显示文摘 | SZE H LIANG F HWANG I | 2000 | Annu Rev Plant Phy-siol2000，51，1： | 1 |
| 19 | Lambda transition of liquid helium as a thermometric fixed point显示文摘 | Hwang K F Khorana B M | 1976 | Metrologia1976，12，2： | 1 |
| 20 | Uncertain Fuzzy Clustering: Interval Type-2 Fuzzy Approach to C-Means 显示文摘 | Hwang C Rhee F C H | 2007 | IEEE Transactions on Fuzzy Systems2007，15，1： | 1 |
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