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| 1 | 锌转运体8自身抗体对急性起病糖尿病患者分型诊断的价值显示文摘目的 探讨锌转运体8自身抗体(ZnT8A)对急性起病糖尿病患者分型诊断的价值.方法 453例急性起病糖尿病患者根据谷氨酸脱羧酶抗体(GADA)和酪氨酸磷酸酶抗体(IA2-A)阳性分为A+组276例(任一抗体阳性)和A-组177例(抗体皆为阴性) 将555例2型糖尿病患者和405名健康者作为对照.分析ZnT8A在急性起病糖尿病患者和亚组中的分布规律、相关因素和ZnT8A阳性者的临床特征.抗体检测采用放射配体法.结果 (1)ZnT8A在急性起病糖尿病组的阳性率为24.3%,显著高于2型糖尿病组(1.8%)和健康对照组(1.0%)(均P<0.01) 而且ZnT8A在A+组中的检出率为29.7%,显著高于A-组患者15.8%(x2=11.318,P<0.01).(2)ZnT8A阳性率在<30岁各亚组高于≥30岁亚组(0~9岁,34.9% 10~19岁,26.7% 20~29岁,26.3%比≥30岁,18.3% 均P<0.05) 在体质指数(BMI)<21.0 kg/m2和21.0~25.0 kg/m2亚组高于BMI>25.0 kg/m2亚组(25.5%和25.9%比8.7%,均P<0.05).(3)ZnT8A水平与IA2-A滴度间呈正相关(r=0.165,P=0.01).(4)3种抗体联合测定使自身免疫检出率从60.9%提高到67.1%.(5)与抗体阴性者相比,ZnT8A单独阳性者日胰岛素需要量较多[(35.5±9.3)U/d比(29.8±14.7)U/d,P<0.05],而收缩压和舒张压均较低[(107±15)mm Hg比(113±16)mm Hg,(69±12)mm Hg比(73±12)mm Hg,均P<0.05].结论 ZnT8A对急性起病糖尿病患者的免疫分型诊断有一定价值,在常见抗体(GADA和IA2-A)阴性者中可识别出一类更接近于经典1型糖尿病的临床表型. | 杨琳 罗说明 黄干 彭健 颜湘 Janet Wenzlau Howard W Davidson John C Hutton 周智广 | 2010 | 中华医学杂志2010，90，36： | 2 |
| 2 | Image distortion correction in fMRI: a quantitative evaluation显示文摘 | Hutton C Bork A Josephs O | 2002 | Neuroimage2002，16，1： | 2 |
| 3 | Metabolism of cigarette smoke condensates by human and rat homogenates to form mutagens detectable by Salmonella typhimurium TA1538 显示文摘 | Hutton J Hackney C | 1975 | Cancer Research1975，35，： | 1 |
| 4 | Determination of the crystal growth rate of paracetamol as a function of solvent composition 显示文摘 | O'Ciardha C T Mitchell N A Hutton K W | 2012 | Ind Eng Chem Res2012，51，12： | 1 |
| 5 | A simple and rapid method for the selection of oligodeoxy-nucleotide-directed mutants显示文摘 | VANDEYAR M A WEINER M P HUTTON C J | 1988 | Gene1988，65，： | 1 |
| 6 | Structure studies of wear debris from carbon-carbon composites aircraft brakes显示文摘 | Toby J Hutton Brian Menandy John C Crelling | 1999 | Carbon1999，37，4： | 1 |
| 7 | Do ben-ding, twisting, and diurnal fluid changes in the disc affect the propensity to prolapse? A viscoelastic finite element model 显示文摘 | LU Y M HUTTON W C GHARPURAY V M | 1996 | Spine (PhilaPa 1976)1996，21，22： | 1 |
| 8 | A comparison between voxel-based cortical thickness and voxel-based morphometry in nor- mal aging显示文摘 | Hutton C Draganski B Ashburner J | 2009 | Neuroimage2009，48，： | 1 |
| 9 | Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis显示文摘 | Marshall S H Donskey C J HuttonThomas R | 2002 | Antimicrob Agents Chemother2002，46，10： | 1 |
| 10 | The effect of hydrostatic pressure on intervertebral disc metabolism显示文摘 | HUTTON W C ELMER W A BODEN S D | 1999 | Spine1999，24，： | 1 |
| 11 | Movement of water in soil due to a temperature gradient显示文摘 | Gurr C G Marshall T J Hutton J T | 1952 | Soil Sci1952，72，： | 1 |
| 12 | Flood inundation model updating using an ensemble Kalman filter and spatially distribu-ted measurements 显示文摘 | NEAL J ATKINSON P M HUTTON C W | 2007 | Journal of Hydrology2007，336，： | 1 |
| 13 | The stages of disc degeneration as revealed by discograms显示文摘 | Adams M A Dolan P Hutton W C | 1986 | J Bone Joint Surg Br1986，68，1： | 1 |
| 14 | Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17显示文摘 | HUTTON M LENDON C L RIZZU P | 1998 | Nature1998，393，： | 1 |
| 15 | The resistance to flexion of thelumbar intervertebral joint显示文摘 | Adams M A Hutton W C Stott J R R | 1980 | Spine1980，5，： | 1 |
| 16 | The effect of posture on the role of the apophysial joints in resisting intervertebral compressive forces 显示文摘 | Adams M A Hutton W C | 1980 | J Bone Joint Surg Br1980，62，3： | 1 |
| 17 | A comparison of pedicle and lateral mass screw construct stiffnesses at the cervicothoracic junction: a biomechanical study 显示文摘 | Rhee JM Kraiwattanapong C Hutton WC | 2005 | Spine2005，30，21： | 1 |
| 18 | Application of inductively coupled plasma source mass spectrometry (ICP-MS) to the determination of trace metals in organics 显示文摘 | Hutton R C | 1986 | Anal At Spectrom1986，，1： | 1 |
| 19 | Association of missense and 5 '-splice-site mutations in tau with the inherited dementia FTDP-17显示文摘 | Hutton M Lendon C L Rizzu P | 1998 | Nature1998，，393： | 1 |
| 20 | Chemical, molecular and isotopic differentiation of organic facies in the Tertiary lacustrine Duaringa oil shale deposit, Queensland, Australia显示文摘 | Boreham C J Summons R E Roksandic Z Dowling L M Hutton A C | 1994 | Org Geochem1994，21，67： | 1 |
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