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| 1 | Open globe injury in Hospital Universiti Sains Malaysia- a 10-year review显示文摘AIM:To identify the aetiology of open globe injuries at Hospital Universiti Sains Malaysia over a period of 10y and the prognostic factors for visual outcome.METHODS:Retrospective review of medical records of open globe injury cases that presented from January2000 to December 2009.Classification of open globe injury was based on the Birmingham Eye Trauma Terminology(BETT).Records were obtained with hospital permission via the in-house electronic patient management system,and the case notes of all patients with a diagnosis of open globe injury were scrutinised.Patients with prior ocular trauma,pre-existing ocular conditions affecting the visual acuity,contrast sensitivity,central vision or corneal thickness,as well as those with a history of previous intraocular or refractive surgery were excluded.Analysis of data was with SPSS version20.0.Ordinal logistic regression analysis was used to examine the association between prognostic factors and visual outcome.RESULTS:This study involved 220 patients(n=222eyes).The most common place of injury was the home(51.8%),followed by the workplace(23.4%).Among children aged less than 16y of age,domestic-related injury was the predominant cause(54.6%),while in those aged 16y and above,occupational injuries were the most common cause(40.0%).Most eyes(76.5%)had an initial visual acuity worse than 3/60,and in half of these,the visual acuity improved.The visual outcome was found to be significantly associated with the initial visual acuity(P<0.005),posterior extent of wound(P<0.001),length of wound(P<0.001),presence of hyphaema(P<0.001)and presence of vitreous prolapse(P<0.005).CONCLUSION:The most common causes of open globe injury are domestic accidents and occupational injuries.Significant prognostic factors for final visual outcome in patients with open globe injury are initial visual acuity,posterior extent and length of wound,presence of hyphaema and presence of vitreous prolapse.Awareness of the factors predicting a poor visual outcome may be helpful during counselling of patients with open globe injuries. | Madhusudhan A/L Paramananda Evelyn-Tai Li Min Zamri Noordin Adil Hussein Wan-Hazabbah Wan Hitam | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 9 |
| 2 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 3 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 4 | 近视矫正评估试验中年龄、性别、种族与近视进展及眼轴延长的关系 | Hyman L Gwiazda J Hussein M 王大江 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，12： | 3 |
| 5 | Multicenter, random- ized, double-blind, placebo-controlled study of thalidomide显示文摘 | Rajkumar SV Rosiol L Hussein M | 2008 | J Clin Oncol2008，26，13： | 1 |
| 6 | A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in children显示文摘 | Gwiazda J Hyman L Hussein M | 2003 | Invest Ophthalmol Vis Sei2003，44，： | 1 |
| 7 | Multicenter,randomized,doubleblind,placebo controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma显示文摘 | Rahjumar SV Rosiol L Hussein W | 2008 | J Clin Oncol2008，26，13： | 1 |
| 8 | A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in chil-dren显示文摘 | Gwiazda J Hyman L Hussein M Everett D Norton TT Kurtz D | 2003 | Invest Ophthalmol Vis Sciy2003，44，4： | 1 |
| 9 | Advanced lattice sup- port structures for metal additive manufacturing显示文摘 | Hussein A Hao L Yan C Z | 2013 | Jour- nal of Materials Processing Technology2013，213，7： | 1 |
| 10 | Acetylcholinesterase inhibitory effects of the bulb of Ammocharis coranica(Amaryllidaceae)and its active constituent lycorine显示文摘 | ELISHA I L ELORASHI E E HUSSEIN A A | 2013 | South African Journal of Botany2013，385，： | 1 |
| 11 | Incidence of adverse out- comes associated with gestational diabetes mellitus in low- and middle - income countries显示文摘 | Wang Z Kanguru L Hussein J | 2013 | Int J Gynaecol Obstet2013，121，1： | 1 |
| 12 | Advanced Lattice Support Structures for Metal Additive Manufactur- ing显示文摘 | Hussein A Hao L Yan C | 2013 | Journal of Materials Processing Technolo- gy2013，213，7： | 1 |
| 13 | Multiple shoots formation of an important tropical medicinal plant, Eurycoma longifoliaJack显示文摘 | Hussein S Rusli I Anna L P K | 2005 | Plant Biotechnol2005，22，： | 1 |
| 14 | Characterization of Ti02-chitosaniglass photocatalyst for the removal of a monoazo dye via photodegradation-adsorption process显示文摘 | Zainal Z Hui L K Hussein M Z Abdullah A H Hamadneh I R | 2009 | Jour?nal of Hazardous Materials2009，164，1： | 1 |
| 15 | Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial显示文摘 | Hyman L Gwiazda J Hussein M | 2005 | Arch Ophthalmol2005，123，7： | 1 |
| 16 | Multicenter,randomized,double-blind,placebo-controlled study ofthalidomide plus dexamethasone compared withdexamethasone as initial therapy for newly diagnosed multiplemyeloma显示文摘 | Rajkumar SV Rosiol L Hussein M | 2008 | J Clin Oncol2008，26，13： | 1 |
| 17 | A multicenter, randomized, doubleblind,placebo -controlled study of thalidomide plus dexamethasone versus dexamethasone as initial therapy for newly diagnosed multiple myeloma显示文摘 | Rajkumar SV Rosinol L Hussein M | 2008 | Clin Oncol2008，26，： | 1 |
| 18 | Removal of dyes using immobilized titanium dioxide illuminated by fluorescent lamps 显示文摘 | Z Zainal L K Hui M Z Hussein | 2005 | J Hazard Mater B2005，125，： | 1 |
| 19 | Calcium Bioavailability from Selected Egyptian Foods with Emphasis on the Impact of Germination and Fermentation显示文摘 | Hussein L Ghanem K Z | 1999 | International Journal of Food Sciences and Nutrition1999，50，： | 1 |
| 20 | Transient ischemic ECG changes in a patient with acute cholocystitis without a history of ischemic heart discase显示文摘 | Kowenstein L Hussein A | 2000 | Harefuah2000，138，6： | 1 |
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