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| 1 | Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss.显示文摘Objective: To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss.(A. palaestinum)(black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity.Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, He La, Hep G2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities.Results: Four flavonoid compounds were isolated(luteolin, chrysoeriol, isoorientin,isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and identification of 15 compounds representing 95.01% of the extract and belonging to different groups of chemical compounds.Conclusions: The present study is considered to be the first report on the cytotoxic activities carried out on different selected fractions and pure compounds of A. palaestinum to provide evidences for its strong antitumor activities. In addition,chrysoeriol and isovitexin compounds were isolated for the first time from the studied taxa. | Mai Mohammed Farid Sameh Reda Hussein Lamiaa Fawzy Ibrahim Mohammed Ali El Desouky Amr Mohammed Elsayed Ahmad Ali El Oqlah Mahmoud Mohammed Saker | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，11： | 1 |
| 2 | An SDL Design and Implementation of a Radiation Monitoring Network Using WCDMA显示文摘 | Ahmed M. Abbas Abdelhalim Zekry Imbaby I. Mahmoud Hussein A. Elsayed | 2012 | 通讯和计算机(中英文版)2012，9，5： | 0 |
| 3 | Cronkhite-Canada syndrome:First case report from Egypt and North Africa显示文摘BACKGROUND Gastrointestinal(GI)polyposis is a rare condition in GI diseases.To date about 500 cases of Cronkhite-Canada syndrome(CCS)have been reported worldwide.CASE SUMMARY We report a 60-year-old female patient who presented with dyspepsia,abdominal pain,and weight loss of 1-year duration.Her physical examination showed alopecia and onychodystrophy.Upper endoscopy revealed diffuse markedly thickened gastric mucosa involving the whole stomach with thickened gastric rugae and numerous polypoidal lesions.Histopathological examination showed marked hyperplasia of the foveolar glands with inflammatory cell infiltration.Endoscopic ultrasound showed a significantly hypertrophic mucosa and muscularis mucosa,while the submucosa and the muscularis propria were spared,favouring its benign nature.Colonoscopy showed multiple sessile polyps scattered at different parts of the colon.Histopathological examination revealed tubular adenomatous polyps with low-grade dysplasia.Differential diagnoses included CCS,Menterier disease(MD),other polyposis syndromes,lymphoma,amyloidosis,and gastric malignancies.The presence of alopecia,nail dystrophy,GI polyposis,markedly thickened gastric mucosa and folds,abdominal pain,weight loss,and marked foveolar gland hyperplasia;all was in favour of CCS.Lymphoma was excluded due to sparing of the muscularis propria.The presence of colonic polyps and antral and duodenal infiltration,and the absence of hypoproteinaemia decreased the possibility for MD.CONCLUSION The patient was diagnosed as having CCS. | Ahmed Elsayed Alzamzamy Ashraf Aboubakr Hussein H Okasha Abeer Abdellatef Shaimaa Elkholy Mahmoudd Wahba Mohamed Alboraie Hussein Elsayed Mohamed O Othman | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 0 |
| 4 | Minimizing Buoyancy Factor of Metallic Pressure-Hull Subjected to Hydrostatic Pressure显示文摘To increase the payload,reduce energy consumption,improve work efficiency and therefore must accordingly reduce the total hull weight of the submersible.This paper introduces a design optimization process for the pressurehull of submarines under uniform external hydrostatic pressure using bothfinite element analysis(FEA)and optimization tools.A comprehensive study about the optimum design of the pressure hull,to minimize the weight and increase the volume,to reach minimum buoyancy factor and maximum operating depth minimizing the buoyancy factor(B.F)is taken as an objective function with constraints of plate and frame yielding,general instability and deflection.The optimization process contains many design variables such as pressure-hull plate thickness,unsupported spacing,dimensions of long and ring beams andfinally the elliptical submersible pressure-hull diameters.The optimization process was conducted using ANSYS parametric design language(APDL)and ISIGHT.The Multi-Island Genetic Algorithm(G.A)is considered to conduct the optimization process.Additionally,parametric analysis is done on the pressure hull to examine the effect of different design variables on the pressure-hull design.As a result,the B.F of the proposed optimal model is reduced by an average of 31.78%compared with Reference Model(RM).Maximum von Mises stress is reduced by 27%as well.These results can be helpful for submarine pressure-hull designers. | Mahmoud Helal Elsayed Fathallah Abdulaziz H Alghtani Hussein Shawki Osman Jong Wan Hu Hasan Eleashy | 2023 | Intelligent Automation & Soft Computing2023，，1： | 0 |
| 5 | Role of endoscopic ultrasound in the characterization of solid pseudopapillary neoplasm of the pancreas显示文摘BACKGROUND Solid pseudopapillary neoplasm(SPN)is an uncommon pathology of the pancreas with unpredictable malignant potential.Endoscopic ultrasound(EUS)assessment plays a vital role in lesion characterization and confirmation of the tissue diagnosis.However,there is a paucity of data regarding the imaging assessment of these lesions.AIM To determine the characteristic EUS features of SPN and define its role in preoperative assessment.METHODS This was an international,multicenter,retrospective,observational study of prospective cohorts from 7 large hepatopancreaticobiliary centers.All cases with postoperative histology of SPN were included in the study.Data collected included clinical,biochemical,histological and EUS characteristics.RESULTS One hundred and six patients with the diagnosis of SPN were included.The mean age was 26 years(range 9 to 70 years),with female predominance(89.6%).The most frequent clinical presentation was abdominal pain(80/106;75.5%).The mean diameter of the lesion was 53.7 mm(range 15 to 130 mm),with the slight predominant location in the head of the pancreas(44/106;41.5%).The majority of lesions presented with solid imaging features(59/106;55.7%)although 33.0%(35/106)had mixed solid/cystic characteristics and 11.3%(12/106)had cystic morphology.Calcification was observed in only 4(3.8%)cases.Main pancreatic duct dilation was uncommon,evident in only 2 cases(1.9%),whilst common bile duct dilation was observed in 5(11.3%)cases.One patient demonstrated a double duct sign at presentation.Elastography and Doppler evaluation demonstrated inconsistent appearances with no emergence of a predictable pattern.EUS guided biopsy was performed using three different types of needles:Fine needle aspiration(67/106;63.2%),fine needle biopsy(37/106;34.9%),and Sonar Trucut(2/106;1.9%).The diagnosis was conclusive in 103(97.2%)cases.Ninety-seven patients were treated surgically(91.5%)and the post-surgical SPN diagnosis was confirmed in all cases.During the 2-year follow-up period,no recurrence was observed.CONCLUSION SPN presented primarily as a solid lesion on endosonographic assessment.The lesion tended to be located in the head or body of the pancreas.There was no consistent characteristic pattern apparent on either elastography or Doppler assessment.Similarly SPN did not frequently cause stricture of the pancreatic duct or common bile duct.Importantly,we confirmed that EUS-guided biopsy was an efficient and safe diagnostic tool.The needle type used does not appear to have a significant impact on the diagnostic yield.Overall SPN remains a challenging diagnosis based on EUS imaging with no pathognomonic features.EUS guided biopsy remains the gold standard in establishing the diagnosis. | Katarzyna M Pawlak Nadeem Tehami Ben Maher Shujaath Asif Krishn Kant Rawal Daniel Vasile Balaban Mohammed Tag-Adeen Fahd Ghalim Wael A Abbas Elsayed Ghoneem Khaled Ragab Mahmoud El-Ansary Shanil Kadir Sunil Amin Keith Siau Anna Wiechowska-Kozlowska Klaus Mönkemüller Dalia Abdelfatah Abeer Abdellatef Sundeep Lakhtakia Hussein Hassan Okasha | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，4： | 0 |
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