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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Minimum aberration 2k-p designs显示文摘 | Fries A Hunter W G | 1980 | Technometrics1980，22，： | 1 |
| 4 | Effect of fatigue on force sensation显示文摘 | JONES L A HUNTER I W | 1983 | EXP Neurol1983，81，： | 1 |
| 5 | Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast ceils protects the cells against oxidative stress 显示文摘 | Balzan R Bannister W H Hunter G J | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 6 | Consumers′ Need for Uniqueness:Scale Development and Validation显示文摘 | Tian K T Bearden W O Hunter G L | 2001 | Journal of Consumer Research2001，28，1： | 1 |
| 7 | Of the structure and diseases of articulating cartilages显示文摘 | Hunter W | | Philos Trarts0，470，： | 1 |
| 8 | Intrapleural immunotherapy with corynebacterium parvum in recurrent malignant pleural effusions显示文摘 | Millar J W Hunter A M Horne N W | 1980 | Thorax1980，35，12： | 1 |
| 9 | Determining the most profitable target value for a production process 显示文摘 | Hunter W G Kartha C P | 1977 | Journal of Quality Technology1977，9，4： | 1 |
| 10 | Ion chromatographic determination of three fructooligosaccharide oligomers in prepared and preserved foods显示文摘 | HOGARTH A J HUNTER D E JACOBS W A | 2000 | Journal of Agricultural and Food Chemistry2000，48，11： | 1 |
| 11 | The absorption spectra of a series of organic molecular compounds 显示文摘 | W H Hunter E H Northey | 1933 | J Phys Chem1933，37，7： | 1 |
| 12 | Nonpoint sources and planning for water pollution control 显示文摘 | Whipple W Hunter J | 1977 | Water Pollut Control Fed1977，49，1： | 1 |
| 13 | Effects of a neem product,RD Repelin on settling behaviour and transmission of zucchini yellow mosaic virus by the pea aphid,Acyrthosiphon pisum(Harris) (Homoptera:Aphididae)显示文摘 | HUNTER W B ULLMAN D E | 1992 | Annals of Applied Biology1992，120，： | 1 |
| 14 | 显示文摘 | M Nevier W R Hunter | 1980 | Applied Optics1980，19，12： | 1 |
| 15 | A review of response surface methodology: a literature survey显示文摘 | Hill W J Hunter W G | 1966 | Teehnometrics1966，8，4： | 1 |
| 16 | Vitamin E biosynthesis : functional characterization of the monocot homogentisate geranylgeranyl transferase 显示文摘 | Yang W Y Cahoon R E Hunter S C | 2011 | The Plant Journal2011，65，： | 1 |
| 17 | Oral sepsis as a cause of disease显示文摘 | Hunter W | 1900 | British Medical Journal1900，2，2065： | 1 |
| 18 | Calcif- ying nanoparticles promote mineralization in vascular smooth muscle cells: implications for atherosclerosis 显示文摘 | Hunter L W Charlesworth J E Yu S | 2014 | Int J Nanomedicine2014，9，： | 1 |
| 19 | Ethylene production by root-nodules and effect of ethylene on nodulation in Glycine max显示文摘 | Hunter W J | 1993 | Applied and Environmental Microbiology1993，59，6： | 1 |
| 20 | Molecular cloning and nucleotide sequence of the alphatoxin (phospholipase c) of Clostridium perfringens 显示文摘 | HUNTER S E C MARTIN K L | 1989 | Infect Immun1989，57，2： | 1 |
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