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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection 显示文摘 | TIPOE G L LEUNG T M HUNG M W | 2007 | Cardiovasc Hematol Disord Drug Targets2007，7，2： | 1 |
| 3 | The sonochemical degradation of azobenzene and related azo dyes:rate enhancements via Fenton's reactions显示文摘 | Joseph J M Destaitlats H Hung H M | 2000 | J Phys Chem A2000，104，2： | 1 |
| 4 | Designing structure-specified mixed optimal controllers using an intelligent genetic algorithm IGA 显示文摘 | Ho S J Ho S Y Hung M H | 2005 | IEEE Trans on Control Systems Technology2005，13，6： | 1 |
| 5 | A Novel Multi-objective Programming Approach Dealing with Qualitative and Quantitative Objectives for Environmental Management显示文摘 | Hung M L Yang W F Ma H W | 2006 | Ecological Economics2006，，56： | 1 |
| 6 | Reaction pathway,energy barrier, and rotational state distribution for LHH2-LiH+H显示文摘 | Chen J J Hung Y M Liu D K | 2001 | J Chern Phys2001，114，21： | 1 |
| 7 | Enhanced electron injection in organic electroluminescence devices using an Al/LiF electrode 显示文摘 | Hung L S Tang C W Mason M G | 1997 | Appl Phys Lett1997，70，： | 1 |
| 8 | Importance of acid polysaccharides for 234Th complexation to marine organic matter显示文摘 | Quigley M S Santschi P H Hung C C | 2002 | Limnology and Oceanography2002，47，： | 1 |
| 9 | Closure of patent foramen ovale for paradoxical emboli: intermediate-term risk of recurrent neurological events following transcatheter device placement 显示文摘 | Hung J Landzberg M J Jenkins K J | 2000 | J Am Coll Cardiol2000，35，5： | 1 |
| 10 | Focusing matrices for co-herent signal-subspace processing显示文摘 | HUNG H S KAVEH M | 1988 | IEEE Transac-tion on ASSP1988，36，8： | 1 |
| 11 | Di- hydrodiol dehydrogenases and polycyclic aromatic hy- drocarbon activation: Generation of reactive and redox active O-quinones 显示文摘 | Penning T M Burczynski M E Hung C F | 1998 | Chemical Research in Toxicolo- gy1998，12，1： | 1 |
| 12 | A randomized prospective evaluation of 3 techniques of postoperative pain management after posterior spinal instrumentation and fusion 显示文摘 | Klatt J W Mickelson J Hung M | 2013 | Spine (Phila Pa 1976)2013，38，19： | 1 |
| 13 | Focusing Matrices for Coherent Sig- nal-Subspace Processing显示文摘 | Hung H Kaveh M | 1988 | IEEE Trans ASSP1988，36，8： | 1 |
| 14 | Extension neural network and its appli- cations 显示文摘 | Wang M H Hung C P | 2003 | Neural Networks2003，16，5： | 1 |
| 15 | Microfiltration for separation of green algae form water显示文摘 | Hung M T Liu J C | 2006 | Colloids surf B2006，51，2： | 1 |
| 16 | On the J-divergence of intuitionistic fuzzy sets with its application to pattern recognition显示文摘 | Hung W L Yang M S | | 0，，06： | 1 |
| 17 | The initial vascu- lar access type contributes to inflammation inincident hemodi- alysis patients显示文摘 | Sachdeva M Hung A Kovalehuk O | 2012 | International Journal of Nephrology2012，，8： | 1 |
| 18 | Investor protection and corporate governance: Evidence from worldwide CEO turnover 显示文摘 | Defond M L Hung M | 2004 | Journal of Accounting Research2004，42，2： | 1 |
| 19 | Fe (Ⅲ ) supported on resin as effective catalyst for the heterogeneous oxidation of phenol in aqueous solution 显示文摘 | Liou R Chen S H Hung M Y | 2005 | Chemosphere2005，59，1： | 1 |
| 20 | Biogeochemical controls on distributions ang fluxes of dissolved and particulate organic carbon in the Northern South China Sea 显示文摘 | HUNG J J WANG S M CHEN Y L | 2007 | Deep-Sea Research II2007，54，： | 1 |
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