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| 1 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 2 | Predicting the impact of climate change on the distribution of two threatened Himalayan medicinal plants of Liliaceae in Nepal显示文摘Predicting the potential distribution of medicinal plants in response to climate change is essential for their conservation and management. Contributing to the management program, this study aimed to predict the distribution of two threatened medicinal plants, Fritillaria cirrhosa and Lilium nepalense. The location of focal species gathered from herbarium specimen housed in different herbaria and online databases were geo-referenced and checked for spatial autocorrelation. The predictive environmental variables were selected, and MaxE nt software was used to model the current and future distributions of focal species. Four Representative Concentration Pathway(RCP) trajectories of the BCC-CSM1.1 model were used as the future(2050) projection layer. The MaxEnt modelling delineated the potential distribution of F. cirrhosa and L. nepalense. The current suitability is projected towards Central and Eastern Hilly/Mountainous regions. Both species gainmaximum suitability in RCP 4.5 which decline towards other trajectories for L. nepalense. Overall, both the focal species shift towards the north-west, losing their potential habitat in hilly and lower mountainous regions by 2050 across all trajectories. Our results highlight the impact of future climate change on two threatened and valuable species. The results can be further useful to initiate farming of these medicinally and economically important species based on climatically suitable zone and for designing a germplasm conservation strategy. | RANA Santosh Kumar RANA Hum Kala GHIMIRE Suresh Kulllar SHRESTHA Krishna Kumar RANJITKAR Sailesh | 2017 | Journal of Mountain Science2017，14，3： | 5 |
| 3 | Geoclimatic factors influence the population genetic connectivity of Incarvillea arguta(Bignoniaceae)in the Himalaya-Hengduan Mountains biodiversity hotspot显示文摘Geoclimatic factors related to the uplift of the Himalaya and the Quaternary climatic oscillations in fluence the population genetic connectivity in the Himalaya-Hengduan Mountains(HHM)biodiversity hotspot.Therefore,to explore the relative roles played by these two factors,we examined the population dynamics and dispersal corridors of Incarvillea arguta(Royle)Royle incorporating ensemble species distribution modelling(SDM).Thirty-seven populations were genotyped using plastid chloroplast DNA and low copy nuclear gene(ncpCS)sequences.Phylogeographic analysis was carried out to reveal the genetic structure and lineage differentiation.Ensemble SDMs were carried out for distributional change in the last glacial maximum,present,and future.Finally,the least cost path method was used to trace out possible dispersal corridors.The haplotypes were divided into four clades with strong geographical structure.The late Miocene origin of I.arguta in the western Himalaya ca.7.92 Ma indicates lineage diversification related to the uplift of the HHM.The variability in habitat connectivity revealed by SDM is due to change in suitability since the Pleistocene.A putative dispersal corridor was detected along the drainage systems and river valleys,with strong support in the eastern Hengduan Mountains group.Our results support the signature of geoclimatic influence on population genetic connectivity of I.arguta in the HHM.We proposed that the major drainage systems might have assisted the rapid dispersal of isolated riverine plant species I.arguta in the HHM.The population genetic connectivity,using the fine-tuned ensemble SDMs,enables scientists and policymakers to develop conservation strategies for the species gene pool in the HHM biodiversity hotspots. | Santosh Kumar Rana Dong Luo Hum Kala Rana Alexander Robert O'Neill Hang Sun | 2021 | Journal of Systematics and Evolution2021，59，1： | 3 |
| 4 | Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL显示文摘 | Seok Min Hong Chan Hum Park Jun Ho Lee | 2009 | Otolaryngology - Head and Neck Surgery2009，，5： | 2 |
| 5 | Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins,which impairs drought stress tolerance显示文摘Drought stress has detrimental effects on plants.Although the abscisic acid(ABA)-mediated drought response is well established,defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely studied.DRR1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub ligase.Suppression of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal movement.Proteotoxicityand dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type plants.These results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress. | Seong Gwan Yu Na Hyun Cho Jong Hum Kim Tae Rin Oh Woo Taek Kim | 2021 | Journal of Integrative Plant Biology2021，63，3： | 2 |
| 6 | Forecasting with artificial neural networks: the state of the art显示文摘 | ZHANG G Q PATUWO E B HUM Y | 1998 | International Journal of Forecasting1998，14，1： | 1 |
| 7 | Testosterone as a modulator of vascular behavior 显示文摘 | Littleton-Kearney M Hum PD | 2004 | Biol Res Nurs2004，5，4： | 1 |
| 8 | Transcriptional regulation of human genes for steroidogenic enzymes显示文摘 | Hum DW Miller WL | 1993 | Clin Chem1993，39，2： | 1 |
| 9 | A Hayes-Wheelwright framework approach for strategic management of third party logistics service显示文摘 | HUM S H | 2000 | Integrated Manufacturing System2000，11，2： | 1 |
| 10 | Major ion chemistry of some large Chinese rivers显示文摘 | HUM H STALLARD R F EDMOND J M | 1982 | Nature1982，298，： | 1 |
| 11 | Dutch national sur- vey to test the STRONGkids nutritional risk screening tool in hospitalized children 显示文摘 | HuM JM Zwart H Hop WC | 2010 | ClinNutr2010，29，： | 1 |
| 12 | Charae- teristies of an isolated greater tuberosity fracture of the humerus 显示文摘 | Kim Eugene Shin Hum Kyu Kim Chung Hwan | 2005 | J Orthop Sei2005，10，5： | 1 |
| 13 | Fabric area network--a new wireless communications infrastructure to enable ubiquitous networking and sensing on intelligent clothing显示文摘 | Hum A P J | 2001 | Computer Networks2001，35，： | 1 |
| 14 | Microstepping Control of Ultrasonic Step- ping Motors 显示文摘 | CHAU K T BIN S HUM Q | 2006 | IEEE Transactions on Industry Applications2006，42，2： | 1 |
| 15 | Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic pa- rameters V(30) and transforming growth factor beta显示文摘 | Fu XL Hum~g H Bentel G | 2001 | Int J Radiat Oncol Biol Phys2001，50，4： | 1 |
| 16 | Evidence of the peripheral inflammatory response in patients with' transient ischeimc attack显示文摘 | Ross A Hum P | 2007 | Journal of Stroke and Cerebrovascular Diseases2007，16，： | 1 |
| 17 | Testosterone as a modulator of vascular behavior显示文摘 | Littleton-Kearney M Hum PD | | 0，，4： | 1 |
| 18 | Developing Energy Conservation and Carbon Reduction Indicators for the Hotel Industry in Tai- wan 显示文摘 | TENG C C HORNG J S HUM L | 2011 | International Journal of Hospitality Management2011，31，1： | 1 |
| 19 | Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases显示文摘 | Johanne Tremblay Richard Desjardins David Hum Jolanta Gutkowska Pavel Hamet | 2002 | Molecular and Cellular Biochemistry (-)2002，，12： | 1 |
| 20 | The Relative Returns frown Research and Teaching: A Market Perspective显示文摘 | Hum D | 2000 | Journal of Educational Administration and Foundations2000，15，1： | 1 |
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