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| 1 | Cerebrospinal fluid and blood biomarkers in Alzheimer’s disease显示文摘Due to an ever aging society and growing prevalence of Alzheimer’s disease(AD),the challenge to meet social and health care system needs will become increasingly difficult.Unfortunately,a definite ante mortem diagnosis is not possible.Thus,an early diagnosis and identification of AD patients is critical for promising,early pharmacological interventions as well as addressing health care needs.The most advanced and most reliable markers areβ-amyloid,total tau and phosphorylated tau in cerebrospinal fluid(CSF).In blood,no single biomarker has been identified despite an intense search over the last decade.The most promising approaches consist of a combination of several bloodbased markers increasing the reliability,sensitivity and specificity of the AD diagnosis.However,contradictory data make standardized testing methods in longitudinal and multi-center studies extremely difficult.In this review,we summarize a range of the most promising CSF and blood biomarkers for diagnosing AD. | Christian Humpel Tanja Hochstrasser | 2011 | World Journal of Psychiatry2011，1，1： | 4 |
| 2 | Can mouse models mimic sporadic Alzheimer’s disease?显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia worldwide.As age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age>60 years.Only<3%of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an age<30 years.In order to study progression of AD,as well as therapeutic strategies,mouse models are state-of-the-art.So far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms develop.Several risk genes,such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a role.In this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD. | Bettina M.Foidl Christian Humpel | 2020 | Neural Regeneration Research2020，15，3： | 4 |
| 3 | Collagen for brain repair:therapeutic perspectives显示文摘Biomaterials have increasingly become a focus of research on neuroprotection and neuroregeneration.Collagen,in terms of brain repair,presents many advantages such as being remarkably biocompatible,biodegradable,versatile and non-toxic.Collagen can be used to form injectable scaffolds and micro/nano spheres in order to:(i) locally release therapeutic factors with the aim of protecting degenerating neurons in neurodegenerative conditions such as Alzheimer's or Parkinson's diseases,(ii) encapsulate stem cells for safe delivery,(iii) encapsulate genetically modified cells to provide a long term source of trophic factors,(iv) fill in the voids from injury to serve as a structural support and provide a permissive microenvironment to promote axonal growth.This mini-review summarizes different applications of collagen biomaterial for central nervous system protection and repair,as well as the future perspectives.Overall,collagen is a promising natural biomaterial with various applications which has the potential to progress the development of therapeutic strategies in central nervous system injuries and degeneration. | Buket Ucar Christian Humpel | 2018 | Neural Regeneration Research2018，13，4： | 3 |
| 4 | Identifying and validating biomarkers for Alzheimer’s disease显示文摘 | Christian Humpel | 2010 | Trends in Biotechnology2010，，1： | 2 |
| 5 | Understanding environmental influences on walking显示文摘 | Neville Owen Nancy Humpel Eva Leslie Adrian Bauman James F Sallis | 2004 | American Journal of Preventive Medicine2004，，1： | 1 |
| 6 | Associations of Location and Perceived Environmental Attributes with Walking in Neighborhoods显示文摘 | Humpel N Owen N Leslie E Marshall A L Bauman A E Sallis J F | 2004 | American Journal of Health Promotion2004，18，3： | 1 |
| 7 | Quantitative analysis of peroxlsome proliferalor-activated receptor gamma expression in arteries and hearts of patients with ischaemic or dilatedcardiomyopathy显示文摘 | Mehrabi M R Haslmayer P Humpeler S | 2003 | EurJ Heart Fail2003，5，6： | 1 |
| 8 | Environmental factors as- sociated with adults' participation in physical activity: A review 显示文摘 | Humpel N Owen N Leslie E | 2002 | American Journal of Preventive Medicine2002，22，3： | 1 |
| 9 | Effects of long-term moderate ethanol and cholesterol on cognition,cholinergic neurons,inflammation,and vascular impairment in rats显示文摘 | Ehrlich D Pirchl M Humpel C | 2012 | Neuroscience2012，205，： | 1 |
| 10 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas显示文摘 | Philipp W Speicher L Humpel C | | 0，，09： | 1 |
| 11 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas 显示文摘 | Philipp W Speicher L Humpel C | 2000 | Invest Ophthalmol Vis Sci2000，41，： | 1 |
| 12 | Exploring the relationship between work stress, years of experience and emotional competency using a sample of Australian mental health nurses 显示文摘 | Humpel N Caputi P Dip G | 2001 | Journal of Psychiatric and Mental Health Nursing2001，8，5： | 1 |
| 13 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas显示文摘 | Philipp W Speicher L Humpel C | 2000 | Invest Ophthalmol Vis Sci2000，41，9： | 1 |
| 14 | Identifying and validating for biomarker for Alzheimer's disease显示文摘 | Humpel C | 2011 | Biotechnol2011，29，1： | 1 |
| 15 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas 显示文摘 | PhiliPp W Speicher L Humpel C | 2000 | Invest Ophthalmol2000，41，9： | 1 |
| 16 | Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized humancorneas显示文摘 | Philipp W Speicher L Humpel C | 2000 | Invest Ophthalmol VisSc2000，41，9： | 1 |
| 17 | Effects of acidosis onbrain capillary endothelial cells and cholinergic neurons:relevance to vascular dementia and Alzheimer′s disease显示文摘 | Pirchl M Marksteiner J Humpel C | 2006 | Neurol Res2006，28，6： | 1 |
| 18 | Environmental factors associated with adults ' participation in physical activity : A review 显示文摘 | Humpel N Owen N Leslie E | 2002 | Am J Prev Med2002，22，3： | 1 |
| 19 | Homocysteine enhances transmigration of rat monocytes through a brmn capillary endothelial cell monolayer via ICAM-I 显示文摘 | Hohsfield LA Humpel C | 2010 | Curt' Neurovasc Res2010，7，3： | 1 |
| 20 | identifying and validating biomarkers for AI- zheimer's disease显示文摘 | Christian Humpel | 2011 | Trends Biotechnol2011，29，1： | 1 |
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