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| 1 | Combined resection and multi-agent adjuvant chemotherapy for desmoplastic small round cell tumor arising in the abdominal cavity:Report of a case显示文摘促结缔织增生的小圆房间肿瘤(DSRCT ) 是有特殊组织学的特征的稀罕、高度好攻击的恶意:在稠密的促结缔织增生基质以内的细胞的生长的一个嵌套的模式,与男优势发生在年轻人口。吝啬的幸存时期仅仅关于 1.5-2.5 年。肿瘤共同表示上皮,在免疫的肌肉,和神经标记组织化学的研究。这个工作报导与吐血和长期的便秘介绍的一个 27 岁的人。包括内视镜检查法,上面的胃肠的系列,腹的计算断层摄影术和钡灌肠的连续研究学习内脏的机关的显示出的传播参与。病人经历了好攻击的外科并且收到了由 5 氟尿嘧啶,出租机动三轮车磷酰胺, etoposide, doxorubicin,和 cisplatin 组成的手术后的辅助化疗。没有任何疾病,他在外科以后为 20 瞬间幸存。没有标准疗法协议被建立了。与手术后的多代理人助手化疗相结合的好攻击的外科被认为正当不仅减轻症状而且试着在这个先进 DSRCT 年轻病人改进结果。 | Chang-Cheng Chang Jun-Te Hsu Jeng-Hwei Tseng Tsann-Long Hwang Han-Ming Chen Yi-Yin Jan | 2006 | World Journal of Gastroenterology2006，12，5： | 104 |
| 2 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 3 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 4 | Dynamic transcriptomic m^6A decoration: writers, erasers, readers and functions in RNA metabolism显示文摘 | Ying Yang Phillip J. Hsu Yu-Sheng Chen Yun-Gui Yang | 2018 | Cell Research2018，28，6： | 99 |
| 5 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 6 | Stress changes on major faults caused by 2013 Lushan earthquake and its relationship with 2008 Wenchuan earthquake显示文摘On April 20, 2013, an Ms7.0 earthquake occurred in Ya'an-Lushan region, Sichuan Province, China, killing and injuring morethan one thousand people. Therefore, it is critical to outline the areas with potential aftershocks before reconstruction andre-settlement as to avoid future disasters. Based on the elastic dislocation theory and multi-layered lithospheric model, we calculate the co-and post-seismic stress changes caused by the Wenchuan and Lushan earthquakes to discuss the relationshipbetween Mw7.9 Wenchuan earthquake and Ms7.0 Lushan earthquake, the influences on the distribution of aftershock caused bythe Lushan earthquake, and the stress changes on major faults in this region. It is shown that the Coulomb failure stress increment on the hypocenter of Lushan earthquake caused by the Wenchuan earthquake is about 0.0037-0.0113 MPa. And the possible maximum value (0.0113 MPa) is larger than the threshold of stress triggering. Therefore, the occurrence of Lushanearthquake is probably effectively promoted by the Wenchuan earthquake. The aftershock distribution is well explained by theco-seismic stress changes of Lushan earthquake. By the two ends of the rupture of Lushan earthquake with increased Coulombfailure stress, a lack of aftershock recordings indicates the high seismic hazard. The stress accumulation and correspondingseismic hazard on the Kangding-Dafu segment of the Xinshuihe fault, the Beichuan-Yingxiu fault, the Pengxian-Guanxianfault, and the Ya'an fault are further increased by the Lushan earthquake and post-seismic process of Wenchuan earthquake. | SHAN Bin XIONG Xiong ZHENG Yong JIN BiKai LIU ChengLi XIE ZhuJun HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 49 |
| 7 | Crustal and upper mantle structure and the deep seismogenic environment in the source regions of the Lushan earthquake and the Wenchuan earthquake显示文摘Following the M w 7.9 Wenchuan earthquake, the M w 6.6 Lushan earthquake is another devastating earthquake that struck the Longmenshan Fault Zone (LFZ) and caused severe damages. In this study, we collected continuous broadband ambient noise seismic data and earthquake event data from Chinese provincial digital seismic network, and then utilized ambient noise tomography method and receiver function method to obtain high resolution shear wave velocity structure, crustal thickness, and Poisson ratio in the earthquake source region and its surroundings. Based on the tomography images and the receiver function results, we further analyzed the deep seismogenic environment of the LFZ and its neighborhood. We reveal three main findings: (1) There is big contrast of the shear wave velocities across the LFZ. (2) Both the Lushan earthquake and the Wenchuan earthquake occurred in the regions where crustal shear wave velocity and crustal thickness change dramatically. The rupture faults and the aftershock zones are also concentrated in the areas where the lateral gradients of crustal seismic wave speed and crustal thickness change significantly, and the focal depths of the earthquakes are concentrated in the transitional depths where shear wave velocities change dramatically from laterally uniform to laterally non-uniform. (3) The Wenchuan earthquake and its aftershocks occurred in low Poisson ratio region, while the Lushan earthquake sequences are located in high Poisson ratio zone. We proposed that the effect of the dramatic lateral variation of shear wave velocity, and the gravity potential energy differences caused by the big contrast in the topography and the crustal thickness across the LFZ may constitute the seismogenic environment for the strong earthquakes in the LFZ, and the Poisson ratio difference between the rocks in the south and north segments of the Longmenshan Fault zone may explain the 5 years delay of the occurrence of the Lushan earthquake than the Wenchuan earthquake. | ZHENG Yong GE Can XIE ZuJun YANG YingJie XIONG Xiong HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 37 |
| 8 | Source parameters inversion of the 2013 Lushan earthquake by combining teleseismic waveforms and local seismograms显示文摘On April 20, 2013, a magnitude M s 7.0 earthquake occurred in Lushan, Sichuan Province, China, and caused heavy casualties and economic losses. Based on the local broadband waveforms in Sichuan and adjacent provinces regional networks and teleseismic broadband records from IRIS stations, the focal mechanism and the focal depth are determined by the CAP (Cut And Paste) and its upgraded methods, CAPtele and CAPjoint, respectively. The results show that the focal mechanisms and depth from different methods are steady, and the best double couple solution derived from the joint inversion is 210°, 44°, and 91° for strike, dip, and rake angles respectively for one nodal plane and 29°, 46°, and 89° for another with 16 km focal depth and M w 6.66 moment magnitude. In order to verify the reliability of the results, a number of tests are performed based on local seismograms with different velocity models. They indicate that there is about 10 degree's fluctuation in focal mechanisms and about 2 km variation in focal depth with a complex velocity structure. Furthermore, inverted by re-sampling the teleseismic waveforms on the basis of epicentral distance, the solutions are consistent with each other, which manifests that the teleseismic records are effective for constraining source parameters of the Lushan earthquake. | XIE ZuJun JIN BiKai ZHENG Yong GE Can XIONG Xiong XIONG Cheng HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 35 |
| 9 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 10 | CYP2C19 polymorphism influences Helicobacter pylori eradication显示文摘The known factors that have contributed to the decline of Helicobacter pylori(H.pylori)eradication rate include antibiotic resistance,poor compliance,high gastric acidity,high bacterial load,and cytochrome P450 2C19(CYP2C19)polymorphism.Proton pump inhibitor(PPI)is important in the eradication regimen.The principal enzyme implicated in the metabolism of PPIs is CYP2C19.The effects of PPI depend on metabolic enzyme,cytochrome P450 enzymes,and CYP2C19 with genetic differences in the activity of this enzyme(the homozygous EM,heterozygous EM(Het EM),and poor metabolizer).The frequency of the CYP2C19 polymorphism is highly varied among different ethnic populations.The CYP2C19genotype is a cardinal factor of H.pylori eradication in patients taking omeprazole-based or lansoprazolebased triple therapies.In contrast,the CYP2C19 polymorphism has no significant effect on the rabeprazolebased or esomeprazole-based triple therapies.The efficacy of levofloxacin-based rescue triple therapy might be also affected by the CYP2C19 polymorphism,but CYP2C19 genotypes did not show obvious impact on other levofloxacin-based rescue therapies.Choice of different PPIs and/or increasing doses of PPIs should be individualized based on the pharmacogenetics background of each patient and pharmacological profile of each drug.Other possible factors influencing gastric acid secretion(e.g.,IL-1β-511 polymorphism)would be also under consideration. | Chao-Hung Kuo Chien-Yu Lu Hsiang-Yao Shih Chung-Jung Liu Meng-Chieh Wu Huang-Ming Hu Wen-Hung Hsu Fang-Jung Yu Deng-Chyang Wu Fu-Chen Kuo | 2014 | World Journal of Gastroenterology2014，20，43： | 33 |
| 11 | 急性缺血性卒中的血管内治疗:神经介入外科学学会实践标准委员会的报告显示文摘目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会(American Heart Association,AHA)以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上,进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。 | K A Blackham P M Meyers T A Abruzzo F C Alberquerque D Fiorella J Fraser D Frei C D Gandhi D V Heck J A Hirsch D P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) | 2012 | 国际脑血管病杂志2012，20，12： | 28 |
| 12 | Reappraisal of endoscopic papillary balloon dilation for the management of common bile duct stones显示文摘Although endoscopic sphincterotomy(EST) is still considered as a gold standard treatment for common bile duct(CBD) stones in western guideline, endoscopic papillary balloon dilation(EPBD) is commonly used by the endoscopists in Asia as the first-line treatment for CBD stones. Besides the advantages of a technical easy procedure, endoscopic papillary large balloon dilation(EPLBD) can facilitate the removal of large CBD stones.The indication of EPBD is now extended from removal of the small stones by using traditional balloon, to removal of large stones and avoidance of lithotripsy by using large balloon alone or after EST. According to the reports of antegrade papillary balloon dilatation, balloon dilation itself is not the cause of pancreatitis. On the contrary, adequate dilation of papillary orifice can reduce the trauma to the papilla and pancreas by the basket or lithotripter during the procedure of stone extraction. EPLBD alone is as effective as EPLBD with limited EST. Longer ballooning time may be beneficial in EPLBD alone to achieve adequate loosening of papillary orifice. The longer ballooning time does not increase the risk of pancreatitis but may reduce the bleeding episodes in patients with coagulopathy. Slowly inflation of the balloon, but not exceed the diameter of bile duct and tolerance of the patients are important to prevent the complication of perforation. EPBLD alone or with EST are not the sphincter preserved procedures, regular follow up is necessary for early detection and management of CBD stones recurrence. | Kwok-Hung Lai Hoi-Hung Chan Tzung-Jiun Tsai Jin-Shiung Cheng Ping-I Hsu | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，2： | 24 |
| 13 | A new look at anti-Helicobacter pylori therapy显示文摘With the rising prevalence of antimicrobial resistance,the treatment success of standard triple therapy has recently declined to unacceptable levels (i.e.,80% or less) in most countries.Therefore,several treatment regimens have emerged to cure Helicobacter pylori (H.pylori) infection.Novel first-line anti-H.pylori therapies in 2011 include sequential therapy,concomitant quadruple therapy,hybrid (dual-concomitant) therapy and bismuth-containing quadruple therapy.After the failure of standard triple therapy,a bismuth-containing quadruple therapy comprising a proton pump inhibitor (PPI),bismuth,tetracycline and metronidazole can be employed as rescue treatment.Recently,triple therapy combining a PPI,levofloxacin and amoxicillin has been proposed as an alternative to the standard rescue therapy.This salvage regimen can achieve a higher eradication rate than bismuth-containing quadruple therapy in some regions and has less adverse effects.The best second-line therapy for patients who fail to eradicate H.pylori with first-line therapies containing clarithromycin,amoxicillin and metronidazole is unclear.However,a levofloxacin-based triple therapy is an accepted rescue treatment.Most guidelines suggest that patients requiring third-line therapy should be referred to a medical center and treated according to the antibiotic susceptibility test.Nonetheless,an empirical therapy (such as levofloxacin-based or furazolidone-based therapies) can be employed to terminate H.pylori infection if antimicrobial sensitivity data are unavailable. | Seng-Kee Chuah Feng-Woei Tsay Ping-I Hsu Deng-Chyang Wu | 2011 | World Journal of Gastroenterology2011，17，35： | 22 |
| 14 | Timing of mortality in severe acute pancreatitis:Experience from 643 patients显示文摘AIM: To determine the timing of mortality after onset of severe acute pancreatitis (SAP) and the course of the disease in a large series of patients. METHODS: From July 1996 to June 2005, all patients diagnosed with acute pancreatitis at Chang Gung Memorial Hospital, Taipei, Taiwan were retrospectively studied. Three thousand two hundred and fifty episodes of acute pancreatitis were recorded in 2248 patients (1431 males and 817 females; median age, 55.6 years; range, 18-97 years). Mortality was divided into two groups: early death (≤ 14 d after admission), and late death (> 14 d after admission). The clinical features of patients in these two groups were compared. RESULTS: Although the overall mortality rate of acute pancreatitis was 3.8% (123/3250), mortality rate of SAP was as high as 16.3% (105/643). Of those 105 SAP mortalities, 44 (41.9%) deaths occurred within the first 14 d after admission and 61 (58.1%) occurred after14 d. Incidence of early death did not significantly differ from that of late death. The co-morbidities did not contribute to the timing of death. Early deaths mainly resulted from multiple organ failure. Late deaths were mainly caused by secondary complication of infected necrosis. Intra- abdominal bleeding significantly caused higher mortality in late death. CONCLUSION: Approximately half (42%) of SAP deaths occur within 14 d and most were due to multiple organ failure. The late deaths of SAP were mostly due to infected necrosis. | Chih-Yuan Fu Chun-Nan Yeh Jun-Te Hsu Yi-Yin Jan Tsann- Long Hwang | 2007 | World Journal of Gastroenterology2007，13，13： | 21 |
| 15 | Video-assisted thoracoscopic surgery (VATS) for bilateral primary spontaneous pneumothorax显示文摘目的将由帮助录像的 thoracoscopic 外科(大桶) 考察我们双边的主要自发的气胸(PSP ) 的治疗的经验。回顾的图表评论被在诊所上或电话会见跟随的材料和方法。病人们被在乎为由在四个医学中心的一位胸的外科医生或在北、中央的台湾的社区医院。有双边的 PSP 的 13 个病人从 1994 年 7 月同时或顺序经历了双边的大桶到 2005 年 12 月。结果与从 15 ~ 36 年(平均数 23.1 年)的年龄, 12 男性和男性女性同时为双边的 PSP 与大桶被对待,在双边的 pneumothoracis 的指示下面(n=4 ) 或顺序(n=9 ) 。在为非同时的 PSP 病人的第一和第二个相反地侧面的大桶过程之间的间隔从 7 d 到 6 年。13 个病人(84.6%) 中的十一个有突出的肺的 bullae/blebs,并且与机械或化学的 pleurodesis 经历了 bullae 切除术。吝啬的起作用的时间是( 45.6 ±1 8.3 ) min (范围 25 ~9 6 min )并且( 120.6 ±2 8.7 ) min (范围 84 ~1 66 min )分别地为非同时(为在第一个大桶以后的相反地侧面的方面的复发的第二个大桶)并且同时(双边的大桶在里面一操作)过程。没有手术后的死亡。然而,延长了漏气(>7 d ) 在在保守治疗以后恢复了的一个病人(7.7%) 发生了。胸试管排水的吝啬的持续时间是 3.1 d 并且中部在时期上面列在后面是 3.4 年。结论大桶是在双边的 PSP 的治疗的一个安全、有效的过程。因为甚至与可见 bullae,复发的发生不在我的组并且在某以前的文学那么高,双边的大桶仅仅与同时双边的 PSP 为病人被推荐。在一个仰卧的位置的双边的大桶应该仅仅在选择情况中被使用,因为可能的肋膜的粘附或在以后的方面上隐藏 bullae。 | Yi-jen CHEN Shi-ping LUH Kun-yen HSU Cheng-ren CHEN Thomas Chang-yao TSAO Jia-yuh CHEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 20 |
| 16 | Correlation between fragmented QRS and the short-term prognosis of patients with acute myocardial infarction显示文摘研究目的:探讨碎裂QRS波对急性心肌梗死患者的短期预后评估的价值,及其对ST段抬高和非ST段抬高型心肌梗死(STEMI和NSTEMI)患者不同的预测价值。创新要点:证实了碎裂QRS波对急性心肌梗死尤其是ST段抬高型心肌梗死的短期预后价值,对早期再灌注治疗有指导意义。研究方法:通过对碎裂QRS波发生及持续时间的详细记录(见图1、2),评价出现碎裂QRS波的STEMI及NSTEMI患者住院期间发生恶性心律失常、泵功能衰竭及住院死亡的风险(见图3;表3–5),并观察早期经皮冠状动脉介入治疗(PCI)对预后的不同影响(见表6)。重要结论:1.急性心肌梗死(尤其是STEMI)患者心电图出现碎裂QRS波短期内易发生恶性心律失常、左心室功能不全及死亡;2.对出现碎裂QRS波的急性心肌梗死患者,早期PCI再灌注治疗可改善患者短期预后。 | Qin-hui SHENG Chih-Chi HSU Jian-ping LI Tao HONG Yong HUO | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，1： | 19 |
| 17 | 仙人掌提取物对蛋鸡产蛋性能、抗氧化能力、免疫功能及血液生化指标的影响显示文摘试验选取360只315日龄罗曼蛋鸡,随机分为4组,每组3个重复,每个重复30只鸡,分别饲喂添加0(对照组)、100、200、300 mg/kg仙人掌提取物的试验日粮,试验期49 d。研究仙人掌提取物对蛋鸡产蛋性能、血液生化指标、抗氧化能力和免疫机能的影响。结果表明:(1)日粮添加仙人掌提取物对蛋鸡采食量无显著影响(P>0.05),可显著提高产蛋率和平均蛋重(P<0.05);(2)200、300 mg/kg添加量水平可显著提高蛋鸡血清中钙、磷的含量,显著降低血清中胆固醇的含量;(3)仙人掌提取物能够提高蛋鸡血清中谷胱甘肽过氧化物酶、超氧化物歧化酶的活性和降低血清中丙二醛的含量;(4)300 mg/kg添加量能够显著提高蛋鸡血清中IgA、IgE、IgM、补体C3和补体C4的含量(P<0.05)。上述结果说明,在饲料中添加仙人掌提取物能够在一定程度上提高蛋鸡产蛋性能、抗氧化能力和免疫功能,改善血液生化指标。 | 顾文松 Li-Wen Hsu | 2012 | 中国饲料2012，，6： | 19 |
| 18 | Liver metastasis from hepatoid adenocarcinoma of the stomach mimicking hepatocellular carcinoma: Dynamic computed tomography findings显示文摘AIM: To evaluate the dynamic computed tomography(CT) findings of liver metastasis from hepatoid adenocarcinoma of the stomach(HAS) and compared them with hepatocellular carcinoma(HCC).METHODS: Between January 2000 and January 2015, 8 patients with pathologically proven HAS and liver metastases were enrolled. Basic tumor status was evaluated for the primary tumor location and metastatic sites. The CT findings of the liver metastases were analyzed for tumor number and size, presence of tumor necrosis, hemorrhage, venous tumor thrombosis, and dynamic enhancing pattern.RESULTS: The body and antrum were the most common site for primary HAS(n = 7), and observed metastatic sites included the liver(n = 8), lymph nodes(n = 7), peritoneum(n = 4), and lung(n = 2). Most of the liver metastases exhibited tumor necrosis regardless of tumor size. By contrast, tumor hemorrhage was observed only in liver lesions larger than 5 cm(n = 4). Three patterns of venous tumor thrombosis were identified: direct venous invasion by the primary HAS(n = 1), direct venous invasion by the liver metastases(n = 7), and isolated portal vein tumor thrombosis(n = 2). Dynamic CT revealed arterial hyperattenuation and late phase washout in all the liver metastases.CONCLUSION: On dynamic CT, liver metastasis from HAS shared many imaging similarities with HCC. For liver nodules, the presence of isolated portal vein tumor thrombosis and a tendency for tumor necrosis are imaging clues that suggest the diagnosis of HAS. | Yang-Yu Lin Chien-Ming Chen Yu-Hsiu Huang Cheng-Yu Lin Sung-Yu Chu Ming-Yi Hsu Kuang-Tse Pan Jeng-Hwei Tseng | 2015 | World Journal of Gastroenterology2015，21，48： | 17 |
| 19 | Antioxidant and antiglycation properties of different solvent extracts from Chinese olive(Canarium album L.) fruit显示文摘Objective:To evaluate the antioxidant activity,antiglycation property,and bioactivc components content of different solvent extracts from Chinese olive(Canarium album L.) fruit.Methods:The dry powder of Chinese olive fruit was extracted with different solvents,i.e.,water,water/ethanol(1/1,v/v),ethanol,methanol,acetone and ethyl acetate.The total phenolic,total flavonoids and total triterpenoids contents of various extracts were determined by spectrophotometric methods.Phenolic compounds were identified by high performance liquid chromatography.The assayed antioxidant activity was determined in vitro models such as antioxidant capacity by radical scavenging activity using 2,2'-azino-bLs(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS),l,l-diphenyl-2-picryl- hydrazyl(DPPH) and nitrite oxide methods,chelating activity on metal ions,lipid and protein peroxidation methods.In vitro glucosebovine serum albumin assay was used to evaluate the antiglycation of various extracts.Results:The water/ethanol extracts of Chinese olive fruit exerted significant scavenging effects on free radicals and strong inhibitory effects on advanced glycation end products formation.The Chinese olive fruit extracts were rich in phenolic compounds and triterpenoids.Gallic acid,ferulic acid and rutin were identified from the water/ethanol extracts.Correlation analysis indicated that there was a linear relationship between the antioxidant potency,free radical scavenging ability and phenolic compounds content of the Chinese olive fruit extracts.Conclusions:Chinese olive fruit could be a natural candidate for studies of dietary complement to diabetes treatment since it combines antioxidant and antiglycation activities. | Chiung-Tsun Kuo Tzu-Hao Liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，12： | 17 |
| 20 | Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas显示文摘瞄准:为了学习 CDH1/E-cadherin (电子恶棍) 的角色,基因改变介绍在胃的癌(GC ) 在激活在 CDH1 的机制包括变化,杂合现象(LOH ) 的损失,倡导者多型性和 hypermethylation。方法:标本与 GC 从 70 个病人通过手术被收集。Allelotyping PCR 和定序的 LOH,使中毒的高压力液相色谱法和 DNA 的察觉,限制碎片长度多型性分析,甲基化 specific PCR,和免疫组织化学的染色被使用。结果:倡导者多型性不是在激活的电子恶棍的主要机制。仅仅一截断变化在一个弥漫的类型肿瘤(3%) 被发现。LOH 和倡导者 hypermethylation 是在激活的电子恶棍的主要机制,但是有趣地,在 CDH1 的肿瘤和 hypermethylation 在突变而产生之遗传的损失(LOH ) 的部分之间有一个否定协会。因此 LOH 和 hypermethylation 是涉及 GC 的二条不同致瘤的小径。结论:给体细胞突变是极其低的,在 LOH 和 hypermethylation 之间的关系是反的调查结果,这三个因素的任何二联合不能在激活完成 CDH1 的古典二点击的假设。因此,在 transcriptional 水平或在 translational 以后水平操作的另外的机制可能被要求在激活导致 E-cadherin。 | Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu Tsai-Yuan Hsieh De-Chuan Chan Cheng-Jueng Chen Jyh-Cherng Yu Cheng-Ping Yu Horng-Jyh Harn Peng-Jen Chen Chung-Bao Hsieh Teng-Wei Chen Huan-Mieng Hsu | 2006 | World Journal of Gastroenterology2006，12，14： | 16 |
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