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| 1 | 海洛因依赖者参加美沙酮维持治疗中存在的问题:小组焦点访谈研究显示文摘目的:了解影响海洛因依赖者参与美沙酮维持治疗(methadone maintenance treatment,MMT)及脱失的相关问题,为MMT门诊制定提高参与率和依从性的干预措施提供依据和线索。方法:分别对上海市的美沙酮维持治疗门诊的9名工作人员和12名正在接受MMT治疗的海洛因依赖者举办小组焦点访谈(focus group,FG),通过半结构式访谈和开放式提问,采集和总结工作人员和患者在MMT参与和维持治疗过程中面临的问题。对访谈内容进行录音和文字记录,并使用定性研究方法分析访谈内容。结果:研究对象指出,在MMT参与和维持过程中主要面临4方面阻碍,影响其参与MMT治疗的积极性和治疗维持率,分别是:(1)部分海洛因依赖者对美沙酮、MMT存在偏见和误解导致对治疗的阻抗;(2)MMT便捷性较差,例如日常门诊时间与工作时间冲突和门诊间转诊不便捷等;(3)每日治疗费用增加了患者的经济负担;(4)海洛因依赖者对司法部门监控的担心。结论:本研究结果提示有必要研究和发展针对性策略以提高MMT的参与率和依从性,例如:宣传教育、经济资助及更人性化的服务。 | 江海峰 杜江 王兆薇 吴霏 Yih-Ing Hser 赵敏 | 2011 | 中国药物依赖性杂志2011，20，6： | 5 |
| 2 | 行为列联管理在美沙酮维持治疗门诊应用效果的初步研究显示文摘目的:探索行为列联管理在美沙酮维持治疗门诊的应用效果。方法:60名接受美沙酮维持治疗的海洛因依赖者被随机分为CM组(n=30)和MMT组(n=30)。对CM组患者实施常规美沙酮维持治疗合并12周行为列联管理,MMT组仅给予常规美沙酮维持治疗。比较两组的成瘾严重程度指数量表、吗啡尿检结果、维持治疗情况。结果:经12周行为列联管理干预后,CM组的职业/社会支持状况显著优于MMT组(P<0.05),阳性尿检次数显著低于MMT组(P<0.01),1 a维持率显著高于MMT组(P<0.05)。结论:行为列联管理技术有助于美沙酮维持治疗门诊的海洛因依赖者改善职业/社会支持状况、减少毒品使用,有助于提高治疗维持率。 | 王军 张怀惠 江海峰 杜江 董爱珍 王建国 陈圣祺 Hser Yi-ing 赵敏 | 2012 | 中国药物依赖性杂志2012，21，1： | 4 |
| 3 | Predicting long-term stable recovery from heroin addiction:findings from a 33-year follow-up study显示文摘 | Hser YI | | 0，，： | 1 |
| 4 | A 33-year follow-up of narcotics addicts显示文摘 | Hser YI Hoffman V Grella CE | 2001 | Arch Gener Psychiatry2001，58，： | 1 |
| 5 | Do patients' perceptions of their counselors influence outcomes of drug treatment?显示文摘 | Kasarabada ND Hser Y Boles SM | 2002 | J Substance Abuse Treatment2002，23，： | 1 |
| 6 | Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicar-um Jack.显示文摘Objective: To investigate protective effects of Hydnophytum formicarum Jack.(H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H_2O_2-induced neurotoxicity in neuroblastoma SH-SY5Y cells. Methods: Cell viability and apoptosis of neuronal cells pretreated with H. formicarum Jack. extracts under oxidative stress were determined by MTT assay and flow cytometry. The intracellular reactive oxygen species(ROS) was performed using Carboxy-DCFDA assay. Additionally, a profile of protein expressions related to neuroprotection was detected by western blot analysis. Results: The plant extracts(methanol and ethyl acetate) elicited protective effects on the neuronal cell death as performed by the MTT assay and by apoptosis analysis via the activation of BCL-2. Both ethyl acetate and methanol extracts exerted inhibitory effects against H_2O_2-induced ROS generation in the SH-SY5Y cells. Furthermore, the possible mechanism of neuroprotection of H. formicarum Jack. was observed through its antioxidant properties by maintaining the levels of catalase and SOD2 proteins as well as activating SIRT1-FOXO3a pathway. Importantly, pretreatment of neuronal cells with H. formicarum Jack. significantly recovered the levels of ADAM10 protein compared with the H_2O_2 treatment alone. Conclusions: The recent findings suggest the protective effects of H. formicarum Jack. plant extracts on attenuating H_2O_2-induced neurotoxicity in human SH-SY5Y cells. | Naw Hser Gay Kamonrat Phopin Wilasinee Suwanjang Waralee Ruankham Prapimpun Wongchitrat Supaluk Prachayasittikul Virapong Prachayasittikul | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，7： | 1 |
| 7 | Predicting Drug Treatment Entry among Treatment-Seeking individuals显示文摘 | Hser YI Maglione M Polinsky ML | 1998 | Journal of Subctance Abuse Treatment1998，15，： | 1 |
| 8 | Sex Difference in Addict Career显示文摘 | Hser Y Anglin D Booth W | 1987 | Amer J Drug Alcohol Abuse1987，13，： | 1 |
| 9 | Predicting drug treatment entry among treatment-seeking individuals显示文摘 | Hser YI Maglione M Polinsky ML | 1998 | J Subst Abuse Treat1998，15，3： | 1 |
| 10 | Cross-system data linkage for treatment outcome evaluation: lessons learned from the california treatment outcome project显示文摘 | Yih-Ing Hser Elizabeth Evans | 2008 | Evaluation and Program Planning2008，31，2： | 1 |
| 11 | Effects of a randomized contingency management intervention on opiate abstinence and retention in methadone maintenance treatment in China显示文摘 | Hser YI Li J Jiang H | 2011 | Addiction (Abingdon England)2011，106，10： | 1 |
| 12 | Trajectorise of Heroin addiction : grouth miture modeling results based on a 33 - year follow - up study 显示文摘 | Hser YI Huang D Chou CP | 2007 | Eval rev2007，31，6： | 1 |
| 13 | Population estimates of intravenous drug users and HIV infection in Los Angeles County显示文摘 | Hser Y | 1993 | Int J Addict1993，28，3： | 1 |
| 14 | An evaluation of drug treatments for adolescents in 4 US cities 显示文摘 | Hser YI Grella CE Hubbard RL | 2001 | Arch Gen Psychiatry2001，58，： | 1 |
| 15 | An evaluation of drug treatments for adolescents in 4 US cities 显示文摘 | Hser YI Grella CE Hubbard RL | 2001 | Arch Gen Psychiatry2001，58，： | 1 |
| 16 | Predictors of Drug Treatment Re-entry Following Relapse to Cocaine Use in DATOS 显示文摘 | GRELLA C E HSER Y I HSIEH S C | 2003 | Journal of Substance Abuse Treatment2003，25，： | 1 |
| 17 | A 33-year follow-up of narcotics addicts 显示文摘 | Hser YI Hoffman V Grella CE | 2001 | Arch Gen Psychiatry2001，58，5： | 1 |
| 18 | Hepatitis C among methadone maintenance treatment patients in Shanghai and Kunming,China显示文摘 | Hser Y Du J Li J | 2012 | J Public Health2012，34，1： | 1 |
| 19 | A 33-year follow-up of narcotics addicts显示文摘 | Hser YI Hoffnan V Grella CE | | 0，，： | 1 |
| 20 | Treatment outcomes among women and men methamphetamine abusers in California显示文摘 | Hser YI Evans E HuangYC | 2005 | J Subst Abuse Treat2005，28，1： | 1 |
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